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Usage Information

Neutrophils are essential for induction of vaccine-like effects by antiviral monoclonal antibody immunotherapies
Mar Naranjo-Gomez, … , Marc Piechaczyk, Mireia Pelegrin
Mar Naranjo-Gomez, … , Marc Piechaczyk, Mireia Pelegrin
Published May 3, 2018
Citation Information: JCI Insight. 2018;3(9):e97339. https://doi.org/10.1172/jci.insight.97339.
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Research Article Infectious disease Therapeutics

Neutrophils are essential for induction of vaccine-like effects by antiviral monoclonal antibody immunotherapies

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Abstract

Using a mouse retroviral model, we have shown that mAb-based immunotherapy can induce life-long endogenous protective immunity (vaccine-like effects). This observation has potentially important consequences for treating life-threatening human viral infections. Here, we investigated the role of neutrophils in this effect. Neutrophils are innate immunity effector cells with well-established microbe-killing activities that are rapidly mobilized upon infection. They are also emerging as orchestrators of innate and adaptive immunities. However, their immunomodulatory activity during antiviral mAb immunotherapies has never been studied. Our data reveal that neutrophils have an essential role in immunotherapy-induced immune protection of infected mice. Unexpectedly, neutrophils have a limited effect in controlling viral propagation upon passive immunotherapy administration, which is mostly mediated by NK cells. Instead, neutrophils operate as essential inducers of a potent host humoral antiviral response. Thus, neutrophils play an unexpected key role in protective immunity induction by antiviral mAbs. Our work opens approaches to improve antiviral immunotherapies, as it suggests that preserving neutrophil functions and counts might be required for achieving mAb-induced protective immunity.

Authors

Mar Naranjo-Gomez, Jennifer Lambour, Marc Piechaczyk, Mireia Pelegrin

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Usage data is cumulative from June 2022 through June 2023.

Usage JCI PMC
Text version 700 89
PDF 55 23
Figure 144 0
Supplemental data 12 1
Citation downloads 23 0
Totals 934 113
Total Views 1,047
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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