ResearchIn-Press PreviewCardiologyPulmonologyVascular biology
Open Access | 
10.1172/jci.insight.205583
A large animal model of heritable pulmonary arterial hypertension using gene-edited BMPR2 sheep
Sanjeev A. Datar,1 Nicholas Werry,2 Austin R. Brown,2 Devon S. Fitzpatrick,2 Oluwafemi Falade,2 Josephine F. Trott,2 Rachel Hutchings,1 Elena K. Amin,1 Jessica M. Morgan,3 Hythem Nawaytou,1 Gail H. Deutsch,4 Eric G. Johnson,3 Omar A. Gonzales Viera,3 Thomas F. Bishop,2 Tara Urbano Beach,3 Bret R. McNabb,3 Eric D. Austin,5 Jeffrey R. Fineman,1 and Alison L. Van Eenennaam2
1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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1Department of Pediatrics, University of California, San Francisco, San Francisco, United States of America
2Department of Animal Science, University of California, Davis, Davis, United States of America
3School of Veterinary Medicine, University of California, Davis, Davis, United States of America
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
5School of Medicine, Vanderbilt University, Nashville, United States of America
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Published July 14, 2026 - More info
Copyright © 2026, Datar et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
