Cycling GLP-1 receptor agonist treatment induces therapeutic resistance and increased adiposity

Anna J. Son; Emmanuel Rapp; Alex Wiezorek; Max G. Leung; Ronadip R. Banerjee; Thomas H. Leung

doi:10.1172/jci.insight.205174

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Research Letter In-Press Preview Endocrinology Metabolism Open Access | 10.1172/jci.insight.205174

Cycling GLP-1 receptor agonist treatment induces therapeutic resistance and increased adiposity

Anna J. Son,¹ Emmanuel Rapp,¹ Alex Wiezorek,¹ Max G. Leung,¹ Ronadip R. Banerjee,² and Thomas H. Leung¹

¹Department of Dermatology, University of Pennsylvania, Philadelphia, United States of America

²Division of Endocrinology, University of Arizona College of Medicine, Tuscon, United States of America

Find articles by Son, A. in: PubMed | Google Scholar

¹Department of Dermatology, University of Pennsylvania, Philadelphia, United States of America

²Division of Endocrinology, University of Arizona College of Medicine, Tuscon, United States of America

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¹Department of Dermatology, University of Pennsylvania, Philadelphia, United States of America

²Division of Endocrinology, University of Arizona College of Medicine, Tuscon, United States of America

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¹Department of Dermatology, University of Pennsylvania, Philadelphia, United States of America

²Division of Endocrinology, University of Arizona College of Medicine, Tuscon, United States of America

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¹Department of Dermatology, University of Pennsylvania, Philadelphia, United States of America

²Division of Endocrinology, University of Arizona College of Medicine, Tuscon, United States of America

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¹Department of Dermatology, University of Pennsylvania, Philadelphia, United States of America

²Division of Endocrinology, University of Arizona College of Medicine, Tuscon, United States of America

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Published March 31, 2026 - More info

JCI Insight. https://doi.org/10.1172/jci.insight.205174.
Copyright © 2026, Son et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Published March 31, 2026 - Version history

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