ResearchIn-Press PreviewCardiologyInflammation
Open Access | 
10.1172/jci.insight.202383
Human pericardial macrophages suppress cardiac fibrosis through cystatin C signaling after myocardial infarction
Ali Fatehi Hassanabad,1 Sarthak Sinha,2 Arzina Jaffer,2 Darrell Belke,3 Nicole L. Rosin,2 Elodie Labit,2 Daniel Young,4 Friederike I. Schoettler,3 Keerthana Chockalingam,2 Benjamin Haeyul Lee,3 Jameson A. Dundas,3 Emilie de Chantal,3 Carmina A. Isidoro,3 Alexander Tam,3 Hanjoo B. Shim,4 Anna N. Zarzycki,3 Afshin Derakhshani,5 Elisabeth Gorgiogianni,3 Jeannine D. Turnbull,3 Antoine Dufour,5 Shalina S. Ousman,6 Jeff A. Biernaskie,2 Paul W.M. Fedak,1 and Justin F. Deniset3
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Fatehi Hassanabad, A. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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Sinha, S.
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Lee, B. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Dundas, J. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Shim, H. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Derakhshani, A. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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Dufour, A.
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Ousman, S. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
Find articles by Biernaskie, J. in: PubMed | Google Scholar
1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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Fedak, P.
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1Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovas, Cumming School of Medicine, University of Calgary, Calgary, Canada
2Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
3Libin Cardiovascular Institute, University of Calgary, Calgary, Canada
4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada
6Departments of Clinical Neuroscience and Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada
7Department of Comparative Biology and Experimental Medicine, University of Calgary, calgary, Canada
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Published July 16, 2026 - More info
Copyright © 2026, Fatehi Hassanabad et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
