Research LetterIn-Press PreviewHepatologyOncology
Open Access | 
10.1172/jci.insight.199200
A rebrand for proteasome inhibition in solid tumors via continuous hepatic artery infusion
Carolina M. Larrain,1 Jack H. Victory,1 Priyanka P. Desai,1 Lindsay R. Friedman,1 Hannah Stepp,1 Rachel Ashe,2 Kirsten Remmert,1 Surajit Sinha,1 Emily C. Smith,1 Nicole Russell,1 Tracey Pu,1 Alyssa V. Eade,1 Justine F. Burke,1 Jason Ho,1 Michael B. Yaffe,1 David E. Kleiner,3 Keith Schmidt,2 William D. Figg,2 and Jonathan M. Hernandez1
1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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2Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
3Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States of America
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Published November 4, 2025 - More info
Copyright © 2025, Larrain et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
