Research LetterIn-Press PreviewNeuroscienceOncology
Open Access | 
10.1172/jci.insight.198475
Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma
Rimas V. Lukas,1 Ruochen Du,2 Harrshavasan Congivaram,2 Kathleen McCortney,2 Karan Dixit,1 Craig Horbinski,2 Margaret Schwartz,1 Raymond Lezon,1 Lauren Singer,3 Ditte Primdahl,1 Jigisha Thakkar,4 Amy B. Heimberger,2 Roger Stupp,1 and Priya Kumthekar1
1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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McCortney, K.
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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Horbinski, C.
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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Heimberger, A.
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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Stupp, R.
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1Department of Neurology, Northwestern University, Chicago, United States of America
2Malnati Brain Tumor Institute, Northwestern University, Chicago, United States of America
3Department of Neurology, University of Chicago, Chicago, United States of America
4Department of Neurology, Loyola University, Chicago, United States of America
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Published February 3, 2026 - More info
Copyright © 2026, Lukas et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
