ResearchIn-Press PreviewImmunologyInflammation
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10.1172/jci.insight.196197
CAR19 Tregs treat murine chronic Graft-Versus-Host Disease through immune suppression in absence of measurable B-cell cytolysis
Sujeong Jin,1 Michael C. Zaiken,1 Cameron McDonald-Hyman,2 Christina R. Hartigan,1 Sara Bolivar-Wagers,1 Jemma H. Larson,1 Yiyun Peng,1 Sophia Hani,1 Megan Riddle,1 Asim Saha,1 Angela Panoskaltsis-Mortari,1 Eun Ko,1 Yujie Zhao,1 Rocio Amaro Marquez,1 Pooja Shree Marri Baskar,1 Cindy R. Eide,1 William J. Murphy,3 Keli L. Hippen,1 Geoffrey R. Hill,4 Jakub Tolar,1 Peter T. Sage,5 Christopher A. Pennell,6 Leslie S. Kean,7 and Bruce R. Blazar1
1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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Jin, S.
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Pediatrics, Division of Pediatric Blood and Marrow Transplant, University of Minnesota Medical School, Minneapolis, United States of America
2Department of Medicine, Division of Hematology, Oncology and Transplantatio, University of Minnesota Medical School, Minneapolis, United States of America
3Department of Dermatology, UCD, Davis, United States of America
4Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America
5Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
6Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, United States of America
7Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
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Published July 14, 2026 - More info
Copyright © 2026, Jin et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
