ResearchIn-Press PreviewImmunologyInflammation
Open Access | 
10.1172/jci.insight.185437
The E3 ubiquitin ligase HECTD3 controls immune colonic inflammation by restricting Myd88 activation and signaling
Shamima Islam,1 Shahnewaj Mannan,1 Ashley Zuniga,2 Upasana Parthasarathy,2 Valeriu B. Cismasiu,1 Leonardo Silvane,1 Sayan Chakraborty,1 Divya Priyanka Talada,1 Raghwendra Pratap Singh,1 Tomas Zelenka,1 Amreen Naveen,1 Sephra Chyanne Vickers,1 Michael G.M. Grant,3 Jonathan J. Cho,2 Theodore Drashansky,2 Alexander J. Kwiatkowski,4 Xintong Liu,5 Ross Tomaino,6 Olga A. Guryanova,7 Mariola J. Ferraro,8 Sang Yong Kim,9 Christian Jobin,10 Benjamin G. Keselowsky,4 Hongmin Li,5 Paulo C. Rodriguez,1 Martina Molgora,1 Amer A. Beg,1 Timothy I. Shaw,11 Zheng Ruan,12 Lixin Wan,3 and Dorina Avram1
1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
Find articles by Islam, S. in: PubMed | Google Scholar
1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
Find articles by Mannan, S. in: PubMed | Google Scholar
1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
Find articles by Zuniga, A. in: PubMed | Google Scholar
1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
Find articles by Cismasiu, V. in: PubMed | Google Scholar
1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
2Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, United States of America
3Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
4J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, United States of America
5Department of Pharmacology and Toxicology, The University of Arizona, Tucson, United States of America
6Taplin Mass Spectrometry Facility, Harvard Medical School, Boston, United States of America
7Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, United States of America
8Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, United States of America
9Department of Pathology, NYU School of Medicine, New York, United States of America
10Division of Gastroenterology, Hepatology, and Nutrition, Department of Medi, University of Florida, Gainesville, United States of America
11Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America
12Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, United States of America
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Published September 24, 2026 - More info
Copyright © 2026, Islam et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
