ResearchIn-Press PreviewAIDS/HIVHematology Open Access | 10.1172/jci.insight.180771
1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, United States of America
2Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
3University of North Carolina Project Malawi, Lilongwe, Malawi
4Department of Pathology, Kamuzu University of Health Sciences, Lilongwe, Malawi
5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, United States of America
6National Cancer Institute Center for Global Health, Rockville, United States of America
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Published May 23, 2024 - More info
The most common subtype of lymphoma globally, diffuse large B-cell lymphoma (DLBCL) is a leading cause of cancer death in people with HIV (HIV+). The restructuring of the T-cell compartment due to HIV infection and antiretroviral therapy (ART) may have implications for modern treatment selection, but current understanding of these dynamic interactions is limited. Here, we investigated the T-cell response to DLBCL by sequencing the T-cell receptor (TCR) repertoire in a cohort of HIV-negative (HIV-), HIV+/ART-experienced and HIV+/ART-naïve DLBCL patients. HIV+/ART-naïve tumor TCR repertoires were more clonal and more distinct from each other than HIV- and HIV+/ART-experienced. Further, increased overlap between tumor and blood TCR repertoires was associated with improved survival and HIV/ART status. Our study describes TCR repertoire characteristics for the first time in an African DLBCL cohort and demonstrates contributions of HIV infection and ART exposure to the DLBCL TCR repertoire.