ResearchIn-Press PreviewImmunologyOncology
Open Access | 
10.1172/jci.insight.176749
Highly multiplexed imaging reveals prognostic immune and stromal spatial biomarkers in breast cancer
Jennifer R. Eng,1 Elmar Bucher,1 Zhi Hu,1 Cameron R. Walker,2 Tyler Risom,3 Michael Angelo,2 Paula Gonzalez-Ericsson,4 Melinda E. Sanders,4 A. Bapsi Chakravarthy,4 Jennifer A. Pietenpol,4 Summer L. Gibbs,1 Rosalie C. Sears,5 and Koei Chin1
1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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Eng, J.
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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1Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America
2Department of Pathology, Stanford University School of Medicine, Stanford, United States of America
3Department of Research Pathology, Genentech, South San Francisco, United States of America
4Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, United States of America
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Published January 14, 2025 - More info
Copyright © 2025, Eng et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
