ResearchIn-Press PreviewMetabolismOncology
Open Access | 10.1172/jci.insight.171225
1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Löding, S.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Kaaks, R.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Pala, V.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Urbarova, I.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Amiano, P.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Colorado-Yohar, S.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Guevara, M.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Heath, A.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Chatziioannou, A.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Johansson, M.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Nyberg, L.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Björkblom, B.
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1Department of Chemistry, Umeå University, Umeå, Sweden
2Biobank Research Unit, Umeå University, Umeå, Sweden
3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
5Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
6Department of Community Medicine, University of Tromso, Tromsø, Norway
7Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastian, Spain
8Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain
9Navarra Institute for Health Research, Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
10Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
11Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
12Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
13Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
14Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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Published August 31, 2023 - More info
Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. As gliomas are currently detected late, a liquid biopsy for early detection could impact the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 pre-diagnostic glioma cases and 550 healthy controls, from the Northern Sweden Health and Disease study (NSHDS) and the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We identified 93 significantly altered metabolites related to glioma development up to eight years before diagnosis. Out of these metabolites, a panel of 20 selected metabolites showed strong disease correlation and consistent progression pattern towards diagnosis in both the NSHDS and EPIC cohorts, and separated favorably future cases from controls independently of biological sex. The blood metabolite panel also successfully separated both lower grade glioma and glioblastoma cases from controls, up to eight years before diagnosis in NSHDS (glioma AUC=0.85, P=3.1e-12; glioblastoma AUC=0.85, P=6.3e-8), and up to two years before diagnosis in EPIC (glioma AUC=0.81, P=0.005; glioblastoma AUC=0.89, P=0.04). Pathway enrichment analysis detected metabolites related to the TCA-cycle, Warburg effect, gluconeogenesis, cysteine-, pyruvate- and tyrosine metabolism as the most affected.