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Open Access | 10.1172/jci.insight.157215
1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Ukita, M.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Hamanishi, J.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Yoshitomi, H.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Takamatsu, S.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Ueda, A.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Suzuki, H.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Furutake, Y.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Yamaguchi, K.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Baba, T.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Matsumura, N.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Ueno, H.
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1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
2Department of immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
3Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
4Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan
5Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan
6Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
7Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medinine, Kyoto, Japan
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Published May 12, 2022 - More info
Tertiary lymphoid structures (TLSs) are transient ectopic lymphoid aggregates whose formation might be caused by chronic inflammation states, such as cancer. However, how TLSs are induced in the tumor microenvironment (TME) and how they affect patient survival are not well understood. We investigated TLS distribution in relation to tumor infiltrating lymphocytes (TILs) and related gene expression in high grade serous ovarian cancer (HGSC) specimens. CXCL13 gene expression correlated with TLS presence and the infiltration of T cells and B cells, and was a favorable prognostic factor for HGSC patients. Coexistence of CD8+ T cells and B-cell lineages in the TME significantly improved the prognosis of HGSC and was correlated with the presence of TLSs. CXCL13 expression was predominantly coincident with CD4+ T cells in TLSs and CD8+ T cells in TILs, and shifted from CD4+ T cells to CD21+ follicular dendritic cells as TLS matured. In a mouse ovarian cancer model, recombinant CXCL13 induced TLSs and enhanced survival by the infiltration of CD8+ T cells. These results suggest that TLS formation was associated with CXCL13-producing CD4+ T cells and that TLSs facilitated the coordinated antitumor response of cellular and humoral immunity in ovarian cancer.