The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small …
M Lohr, K Edlund, J Botling, S Hammad, B Hellwig… - Cancer letters, 2013 - Elsevier
Cancer letters, 2013•Elsevier
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in
cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC
expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue
microarray. IGKC protein expression was independently associated with longer survival,
with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen
with CD138+ cells, but not with CD20. CD138 expression revealed a comparable …
cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC
expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue
microarray. IGKC protein expression was independently associated with longer survival,
with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen
with CD138+ cells, but not with CD20. CD138 expression revealed a comparable …
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma–infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.
Elsevier