ResearchIn-Press PreviewMetabolism
Open Access | 
10.1172/jci.insight.155552
The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
Peng Zhao,1 Xiaoli Sun,2 Zhongji Liao,3 Hong Yu,4 Dan Li,5 Zeyang Shen,6 Christopher K. Glass,7 Joseph L. Witztum,3 and Alan R. Saltiel3
1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
2Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, United States of America
3Department of Medicine, University of California San Diego, La Jolla, United States of America
4Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
5Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States of America
6Department of Bioengineering, University of California San Diego, La Jolla, United States of America
7Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, United States of America
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Published August 2, 2022 - More info
Copyright © 2022, Zhao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
