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Abstract
Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mount a humoral immune response to the virus within a few weeks of infection, but the duration of this response and how it correlates with clinical outcomes has not been completely characterized. Of particular importance is the identification of immune correlates of infection that would support public health decision-making on treatment approaches, vaccination strategies, and convalescent plasma therapy. While ELISA-based assays to detect and quantitate antibodies to SARS-CoV-2 in patient samples have been developed, the detection of neutralizing antibodies typically requires more demanding cell-based viral assays. Here, we present a safe and efficient protein-based assay for the detection of serum and plasma antibodies that block the interaction of the SARS-CoV-2 spike protein receptor binding domain (RBD) with its receptor, angiotensin-converting enzyme 2 (ACE2). The assay serves as a surrogate neutralization assay and is performed on the same platform and in parallel with an ELISA for the detection of antibodies against the RBD, enabling a direct comparison. The results obtained with our assay correlate with those of 2 viral-based assays, a plaque reduction neutralization test (PRNT) that uses live SARS-CoV-2 virus and a spike pseudotyped viral vector–based assay.
Authors
Kento T. Abe, Zhijie Li, Reuben Samson, Payman Samavarchi-Tehrani, Emelissa J. Valcourt, Heidi Wood, Patrick Budylowski, Alan P. Dupuis II, Roxie C. Girardin, Bhavisha Rathod, Jenny H. Wang, Miriam Barrios-Rodiles, Karen Colwill, Allison J. McGeer, Samira Mubareka, Jennifer L. Gommerman, Yves Durocher, Mario Ostrowski, Kathleen A. McDonough, Michael A. Drebot, Steven J. Drews, James M. Rini, Anne-Claude Gingras
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Citations to this article in year 2021 (54)
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Dried blood spot specimens for SARS-CoV-2 antibody testing: A multi-site, multi-assay comparison
F Cholette, C Mesa, A Harris, H Ellis, K Cachero, P Lacap, Y Galipeau, MA Langlois, AC Gingras, CP Yansouni, J Papenburg, MP Cheng, P Chakraborty, DR Stein, PV Caeseele, S Bartlett, M Krajden, D Goldfarb, A McGeer, C Osiowy, C Hankins, B Mazer, M Drebot, J Kim, GK Nasrallah |
PloS one | 2021 |
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A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2
TS Fulford, H Van, NA Gherardin, S Zheng, M Ciula, HE Drummer, S Redmond, HX Tan, I Boo, RJ Center, F Li, SL Grimley, BD Wines, TH Nguyen, FL Mordant, P Ellenberg, LC Rowntree, L Kedzierski, AC Cheng, DL Doolan, G Matthews, K Bond, PM Hogarth, Z McQuilten, K Subbarao, K Kedzierska, JA Juno, AK Wheatley, SJ Kent, DA Williamson, DF Purcell, DA Anderson, DI Godfrey |
EBioMedicine | 2021 |
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Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine: Secondary Analysis of a Randomized Trial
D Kumar, VH Ferreira, VG Hall, Q Hu, R Samson, T Ku, M Ierullo, B Majchrzak-Kita, G Tomlinson, AC Gingras, A Humar |
Annals of internal medicine | 2021 |
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A novel competition ELISA for the rapid quantification of SARS‐CoV ‐2 neutralizing antibodies in convalescent plasma
E Wouters, C Verbrugghe, R Devloo, I Debruyne, DD Clippel, LV Heddegem, KV Asch, VV Gaver, M Vanbrabant, A Muylaert, V Compernolle, HB Feys |
Transfusion | 2021 |
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Antigenic characterization of influenza and SARS-CoV-2 viruses
Y Wang, CY Tang, XF Wan |
Analytical and Bioanalytical Chemistry | 2021 |
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Overview of Neutralizing Antibodies and Their Potential in COVID-19
JJ Morales-Núñez, JF Muñoz-Valle, PC Torres-Hernández, J Hernández-Bello |
Human vaccines | 2021 |
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Differential Antibody Response to Inactivated COVID-19 Vaccines in Healthy Subjects
J Zhang, S Xing, D Liang, W Hu, C Ke, J He, R Yuan, Y Huang, Y Li, D Liu, X Zhang, L Li, J Lin, W Li, X Teng, Y Liu, W Wen, Q Kang, D Wang, W Liu, J Xu |
Frontiers in Cellular and Infection Microbiology | 2021 |
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Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay
AO Shalash, A Azuar, HY Madge, N Modhiran, AA Amarilla, B Liang, AA Khromykh, D Watterson, PR Young, I Toth, M Skwarczynski |
Human vaccines | 2021 |
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Adapting Serosurveys for the SARS-CoV-2 Vaccine Era
N Duarte, M Yanes-Lane, R Arora, N Bobrovitz, M Liu, M Bego, T Yan, C Cao, C Gurry, C Hankins, M Cheng, A Gingras, B Mazer, J Papenburg, M Langlois |
Open Forum Infectious Diseases | 2021 |
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Advances in Neutralization Assays for SARS‐CoV‐2
Lu Y, Wang J, Li Q, Hu H, Lu J, Chen Z |
Scandinavian Journal of Immunology | 2021 |
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Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies
Esmail S, Knauer MJ, Abdoh H, Voss C, Chin-Yee B, Stogios P, Seitova A, Hutchinson A, Yusifov F, Skarina T, Evdokimova E, Ackloo S, Lowes L, Hedley BD, Bhayana V, Chin-Yee I, Li SS |
2021 | |
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SPEEDS: A portable serological testing platform for rapid electrochemical detection of SARS-CoV-2 antibodies
Peng R, Pan Y, Li Z, Qin Z, Rini JM, Liu X |
Biosensors & bioelectronics | 2021 |
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Track-etched membrane microplate and smartphone immunosensing for SARS-CoV-2 neutralizing antibody
Wang C, Wu Z, Liu B, Zhang P, Lu J, Li J, Zou P, Li T, Fu Y, Chen R, Zhang L, Fu Q, Li C |
Biosensors & bioelectronics | 2021 |
