Usage Information
Citation Information: JCI Insight. 2021;6(9):e136233. https://doi.org/10.1172/jci.insight.136233.
Abstract
White adipose tissue not only serves as a reservoir for energy storage but also secretes a variety of hormonal signals and modulates systemic metabolism. A substantial amount of adipose tissue develops in early postnatal life, providing exceptional access to the formation of this important tissue. Although a number of factors have been identified that can modulate the differentiation of progenitor cells into mature adipocytes in cell-autonomous assays, it remains unclear which are connected to physiological extracellular inputs and are most relevant to tissue formation in vivo. Here, we elucidate that mature adipocytes themselves signal to adipose depot–resident progenitor cells to direct depot formation in early postnatal life and gate adipogenesis when the tissue matures. Our studies revealed that as the adipose depot matures, a signal generated in mature adipocytes is produced, converges on progenitor cells to regulate the cytoskeletal protein MYH9, and attenuates the rate of adipogenesis in vivo.
Authors
Sin Ying Cheung, Mohd Sayeed, Krishnamurthy Nakuluri, Liang Li, Brian J. Feldman
Usage data is cumulative from January 2022 through January 2023.
| Usage | JCI | PMC |
|---|---|---|
| Text version | 1,763 | 121 |
| 147 | 36 | |
| Figure | 208 | 0 |
| Supplemental data | 32 | 3 |
| Citation downloads | 33 | 0 |
| Totals | 2,183 | 160 |
| Total Views | 2,343 | |
Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.
Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.
