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Citations to this article

Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients
Colt A. Egelston, … , Yuan Yuan, Peter P. Lee
Colt A. Egelston, … , Yuan Yuan, Peter P. Lee
Published August 29, 2019
Citation Information: JCI Insight. 2019;4(19):e130000. https://doi.org/10.1172/jci.insight.130000.
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Research Article Immunology Oncology Article has an altmetric score of 4

Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients

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Abstract

CD8+ tumor-infiltrating lymphocytes (TILs) correlate with relapse-free survival (RFS) in most cancer types, including breast cancer. However, subset composition, functional status, and spatial location of CD8+ TILs in relation to RFS in human breast tumors remain unclear. Spatial tissue analysis via quantitative immunofluorescence showed that infiltration of CD8+ T cells into cancer islands was more significantly associated with RFS than CD8+ T cell infiltration into either tumor stroma or total tumor. Localization into cancer islands within tumors is mediated by expression of the integrin CD103, which is a marker for tissue-resident memory T cells (TRMs). Analysis of fresh tumor samples revealed that CD8+ TRMs are functionally similar to other CD8+ TILs, suggesting that the basis of their protective effect is their spatial distribution rather than functional differences. Indeed, CD103+ TRMs, as compared with CD103–CD8+ TILs, are enriched within cancer islands, and CD8+ TRM proximity to cancer cells drives the association of CD8+ TIL densities with RFS. Together, these findings reveal the importance of cancer island–localized CD8+ TRMs in surveillance of the breast tumor microenvironment and as a critical determinant of RFS in patients with breast cancer.

Authors

Colt A. Egelston, Christian Avalos, Travis Y. Tu, Anthony Rosario, Roger Wang, Shawn Solomon, Gayathri Srinivasan, Michael S. Nelson, Yinghui Huang, Min Hui Lim, Diana L. Simons, Ting-Fang He, John H. Yim, Laura Kruper, Joanne Mortimer, Susan Yost, Weihua Guo, Christopher Ruel, Paul H. Frankel, Yuan Yuan, Peter P. Lee

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 Total
Citations: 5 10 13 23 18 8 77
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (8)

Title and authors Publication Year
TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals
F Manfredi, BC Cianciotti, A Potenza, E Tassi, M Noviello, A Biondi, F Ciceri, C Bonini, E Ruggiero
Frontiers in immunology 2020
Breast Cancer Heterogeneity and Response to Novel Therapeutics
M Baliu-Piqué, A Pandiella, A Ocana
Cancers 2020
Memory CD8+ T cell responses to cancer
J Han, N Khatwani, TG Searles, MJ Turk, CV Angeles
Seminars in Immunology 2020
Tissue-resident memory-like T cells in tumor immunity: Clinical implications
MV Dhodapkar, KM Dhodapkar
Seminars in Immunology 2020
Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types
JK Khalsa, N Cheng, J Keegan, A Chaudry, J Driver, WL Bi, J Lederer, K Shah
Nature Communications 2020
Resident Memory T Cells and Their Effect on Cancer
DJ Craig, JF Creeden, KR Einloth, CE Gillman, L Stanbery, D Hamouda, G Edelman, L Dworkin, JJ Nemunaitis
Human vaccines 2020
Racial differences in CD8+ T cell infiltration in breast tumors from Black and White women
Y Abdou, K Attwood, TY Cheng, S Yao, EV Bandera, GR Zirpoli, RP Ondracek, L Stein, W Bshara, T Khoury, CB Ambrosone, AR Omilian
Breast Cancer Research 2020
The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer
SL Goff, DN Danforth
Clinical Breast Cancer 2020

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