Citations to this article
Citation Information: JCI Insight. 2019;4(6):e126688. https://doi.org/10.1172/jci.insight.126688.
Abstract
Bariatric surgeries including vertical sleeve gastrectomy (VSG) ameliorate obesity and diabetes. Weight loss and accompanying increases to insulin sensitivity contribute to improved glycemia after surgery; however, studies in humans also suggest weight-independent actions of bariatric procedures to lower blood glucose, possibly by improving insulin secretion. To evaluate this hypothesis, we compared VSG-operated mice with pair-fed, sham-surgical controls (PF-Sham) 2 weeks after surgery. This paradigm yielded similar postoperative body weight and insulin sensitivity between VSG and calorically restricted PF-Sham animals. However, VSG improved glucose tolerance and markedly enhanced insulin secretion during oral nutrient and i.p. glucose challenges compared with controls. Islets from VSG mice displayed a unique transcriptional signature enriched for genes involved in Ca2+ signaling and insulin secretion pathways. This finding suggests that bariatric surgery leads to intrinsic changes within the islet that alter function. Indeed, islets isolated from VSG mice had increased glucose-stimulated insulin secretion and a left-shifted glucose sensitivity curve compared with islets from PF-Sham mice. Isolated islets from VSG animals showed corresponding increases in the pulse duration of glucose-stimulated Ca2+ oscillations. Together, these findings demonstrate a weight-independent improvement in glycemic control following VSG, which is, in part, driven by improved insulin secretion and associated with substantial changes in islet gene expression. These results support a model in which β cells play a key role in the adaptation to bariatric surgery and the improved glucose tolerance that is typical of these procedures.
Authors
Jonathan D. Douros, Jingjing Niu, Sophia Sdao, Trillian Gregg, Kelsey Fisher-Wellman, Manish Bharadwaj, Anthony Molina, Ramamani Arumugam, MacKenzie Martin, Enrico Petretto, Matthew J. Merrins, Mark A. Herman, Jenny Tong, Jonathan Campbell, David D’Alessio
Citations to this article (27)
| Title and authors | Publication | Year |
|---|---|---|
|
Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat
Brial F, Le Lay A, Rouch C, Henrion E, Bourgey M, Bourque G, Lathrop M, Magnan C, Gauguier D |
Molecular Brain | 2025 |
|
Metabolic-Bariatric Surgery for Type 2 Diabetes: Time(ing) for a Change
Purnell JQ |
Diabetes | 2024 |
|
Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice
Soares GM, Lopes LE, Balbo SL, Marmentini C, Bronczek GA, Kurauti MA, Bonfleur ML, Velloso LA, Carneiro EM, Boschero AC, Costa-Júnior JM |
International journal of molecular sciences | 2023 |
|
Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes
Liu T, Zou X, Ruze R, Xu Q |
Frontiers in Endocrinology | 2023 |
|
Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity
Womble JT, Ihrie MD, McQuade VL, Hegde A, McCravy MS, Phatak S, Tighe RM, Que LG, D\u2019Alessio D, Walker JK, Ingram JL |
Frontiers in Endocrinology | 2023 |
|
An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes
Soldovieri L, Di Giuseppe G, Ciccarelli G, Quero G, Cinti F, Brunetti M, Nista EC, Gasbarrini A, Alfieri S, Pontecorvi A, Giaccari A, Mezza T |
Molecular Metabolism | 2023 |
|
The impact of prior obesity surgery on glucose metabolism after body contouring surgery: A pilot study.
Badran S, Doi SA, Hammouda A, Khoogaly H, Muneer M, Alkasem MJ, Abou-Samra AB, Habib AM |
2023 | |
|
Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice
Samuel I, Ben-Haroush Schyr R, Arad Y, Attali T, Azulai S, Bergel M, Halfon A, Hefetz L, Hirsch T, Israeli H, Lax N, Nitzan K, Sender D, Sweetat S, Okun E, Rosenmann H, Ben-Zvi D |
Frontiers in neuroscience | 2022 |
|
Do bariatric patient's in rural areas achieve comparative weight loss as national average? single center experience in appalachia west virginia.
Corsello J, Gerola R, Babatope M, Munie S, Nease DB |
Surgical Endoscopy | 2022 |
|
Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice
Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras AD, Leclerc I, Rutter GA |
Frontiers in Endocrinology | 2022 |
|
The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function.
Shin JH, Bozadjieva-Kramer N, Shao Y, Lyons-Abbott S, Rupp AC, Sandoval DA, Seeley RJ |
Cell Metabolism | 2022 |
|
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems
Yang B, Gelfanov VM, El K, Chen A, Rohlfs R, DuBois B, Kruse Hansen AM, Perez-Tilve D, Knerr PJ, D'Alessio D, Campbell JE, Douros JD, Finan B |
Molecular Metabolism | 2022 |
|
Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice
L Ding, E Zhang, Q Yang, L Jin, KM Sousa, B Dong, Y Wang, J Tu, X Ma, J Tian, H Zhang, Z Fang, A Guan, Y Zhang, Z Wang, DD Moore, L Yang, W Huang |
Proceedings of the National Academy of Sciences | 2021 |
|
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes
L Oppenländer, S Palit, K Stemmer, T Greisle, M Sterr, C Salinno, A Bastidas-Ponce, A Feuchtinger, A Böttcher, Ansarullah, FJ Theis, H Lickert |
Molecular Metabolism | 2021 |
|
The Human Islet: Mini-Organ With Mega-Impact
JT Walker, DC Saunders, M Brissova, AC Powers |
Endocrine reviews | 2021 |
|
Sleeve Gastrectomy Suppresses Hepatic Glucose Production and Increases Hepatic Insulin Clearance Independent of Weight Loss
RB Schyr, A Al-Kurd, B Moalem, A Permyakova, H Israeli, A Bardugo, Y Arad, L Hefetz, M Bergel, A Haran, S Azar, I Magenheim, J Tam, R Grinbaum, D Ben-Zvi |
Diabetes | 2021 |
|
Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies
YA Lee, SL Friedman |
Journal of Internal Medicine | 2021 |
|
Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
E Akalestou, K Suba, L Lopez-Noriega, E Georgiadou, P Chabosseau, A Gallie, A Wretlind, C Legido-Quigley, I Leclerc, V Salem, GA Rutter |
Nature Communications | 2021 |
|
Experimental Induction of Type 2 Diabetes Mellitus and the Efficiency of Bariatric Surgery in its Reversal in Rats
L Hritcu |
ACTA ENDOCRINOL-BUCH | 2021 |
|
A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice
C Amouyal, J Castel, C Guay, A Lacombe, J Denom, S Migrenne-Li, C Rouault, F Marquet, E Georgiadou, T Stylianides, S Luquet, HL Stunff, R Scharfmann, K Clément, GA Rutter, O Taboureau, C Magnan, R Regazzi, F Andreelli |
EBioMedicine | 2020 |
|
Repositioning the Alpha Cell in Postprandial Metabolism
K El, ME Capozzi, JE Campbell |
Endocrinology | 2020 |
|
Could micro changes in β-cells enable major changes in metabolism?
ME Capozzi, JE Campbell |
EBioMedicine | 2020 |
|
PYY, a Therapeutic Option for Type 2 Diabetes?
C Guida, R Ramracheya |
Clinical Medicine Insights. Endocrinology and Diabetes | 2020 |
|
Meal patterns after bariatric surgery in mice and rats
H Shah, AC Shin |
Appetite | 2020 |
|
Glucagon-like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Davis EM, Sandoval DA |
Comprehensive Physiology | 2020 |
|
The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control
JD Douros, J Tong, DA DAlessio |
Endocrine reviews | 2019 |
|
Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control
JD Douros, J Niu, S Sdao, T Gregg, MJ Merrins, J Campbell, J Tong, D D'Alessio |
Molecular Metabolism | 2019 |
