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Citations to this article

Microbiota-dependent signals are required to sustain TLR-mediated immune responses
Lehn K. Weaver, … , Kim E. Nichols, Edward M. Behrens
Lehn K. Weaver, … , Kim E. Nichols, Edward M. Behrens
Published January 10, 2019
Citation Information: JCI Insight. 2019;4(1):e124370. https://doi.org/10.1172/jci.insight.124370.
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Research Article Inflammation Article has an altmetric score of 9

Microbiota-dependent signals are required to sustain TLR-mediated immune responses

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Abstract

Host-commensal interactions are critical for the generation of robust inflammatory responses, yet the mechanisms leading to this effect remain poorly understood. Using a murine model of cytokine storm, we identified that host microbiota are required to sustain systemic TLR-driven immune responses. Mice treated with broad-spectrum antibiotics or raised in germ-free conditions responded normally to an initial TLR signal but failed to sustain production of proinflammatory cytokines following administration of repeated TLR signals in vivo. Mechanistically, host microbiota primed JAK signaling in myeloid progenitors to promote TLR-enhanced myelopoiesis, which is required for the accumulation of TLR-responsive monocytes. In the absence of TLR-enhanced monocytopoiesis, antibiotic-treated mice lost their ability to respond to repeated TLR stimuli and were protected from cytokine storm–induced immunopathology. These data reveal priming of TLR-enhanced myelopoiesis as a microbiota-dependent mechanism that regulates systemic inflammatory responses and highlight a role for host commensals in the pathogenesis of cytokine storm syndromes.

Authors

Lehn K. Weaver, Danielle Minichino, Chhanda Biswas, Niansheng Chu, Jung-Jin Lee, Kyle Bittinger, Sabrin Albeituni, Kim E. Nichols, Edward M. Behrens

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 Total
Citations: 6 8 4 2 8 2 30
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (8)

Title and authors Publication Year
CD4 and CD8 T Cell Memory Interactions Alter Innate Immunity and Organ Injury in the CLP Sepsis Model
MD Taylor, TD Fernandes, AP Kelly, MN Abraham, CS Deutschman
Frontiers in immunology 2020
Using the Extremes of Human Inflammation to Understand the Transcriptional Control of IL-18
WB LaRivière, EP Schmidt
American journal of respiratory and critical care medicine 2020
The role for the metagenome in the pathogenesis of COVID-19
RP Friedland, B Haribabu
EBioMedicine 2020
The gut microbiome: an under-recognised contributor to the COVID-19 pandemic?
JP Segal, JW Mak, BH Mullish, JL Alexander, SC Ng, JR Marchesi
Therapeutic advances in gastroenterology 2020
Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies
L Chen, J Li, W Zhu, Y Kuang, T Liu, W Zhang, X Chen, C Peng
Frontiers in microbiology 2020
Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis
M Märklin, S Bugl, S Wirths, JS Frick, MR Müller, HG Kopp, D Schneidawind
Experimental biology and medicine (Maywood, N.J.) 2020
Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD
Jonscher KR, Abrams J, Friedman JE
Journal of cellular immunology 2020
The Impact of SARS-CoV-2 on the Human Immune System and Microbiome
Wang C, Zhou X, Wang M, Chen X
2020

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