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Citations to this article

Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma
Pablo Vieyra-Garcia, … , Peter Wolf, Rachael A. Clark
Pablo Vieyra-Garcia, … , Peter Wolf, Rachael A. Clark
Published January 10, 2019
Citation Information: JCI Insight. 2019;4(1):e124233. https://doi.org/10.1172/jci.insight.124233.
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Research Article Dermatology Immunology Article has an altmetric score of 5

Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma

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Abstract

Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant T cells and induced clonal expansion of CD8+ T cells associated with malignant T cell depletion. High-burden patients appeared to clinically improve but large numbers of malignant T cells persisted in skin. Clinical improvement was linked to turnover of benign T cell clones but not to malignant T cell reduction. Benign T cells were associated with the Th2-recruiting chemokine CCL18 before therapy and with the Th1-recruiting chemokines CXCL9, CXCL10, and CXCL11 after therapy, suggesting a switch from Th2 to Th1. Inflammation was correlated with OX40L and CD40L gene expression; immunostaining localized these receptors to CCL18-expressing c-Kit+ dendritic cells that clustered together with CD40+OX40+ benign and CD40+CD40L+ malignant T cells, creating a proinflammatory synapse in skin. Our data suggest that visible inflammation in CTCL results from the recruitment and activation of benign T cells by c-Kit+OX40L+CD40L+ dendritic cells and that this activation may provide tumorigenic signals. Targeting c-Kit, OX40, and CD40 signaling may be novel therapeutic avenues for the treatment of MF.

Authors

Pablo Vieyra-Garcia, Jack D. Crouch, John T. O’Malley, Edward W. Seger, Chao H. Yang, Jessica E. Teague, Anna Maria Vromans, Ahmed Gehad, Thet Su Win, Zizi Yu, Elizabeth L. Lowry, Jung-Im Na, Alain H. Rook, Peter Wolf, Rachael A. Clark

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 2 4 8 5 6 6 4 35
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Citations to this article (35)

Title and authors Publication Year
A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL
Luo Y, Vermeer M, Linssen MM, de Bie FJ, Pijnacker-Verspuij M, Brouwers C, Claassens J, de Gruijl FR, Hohenstein P, Tensen CP
Scientific Reports 2025
Case report of non-gene editing CD7 CAR T cell therapy in CD7+ Sézary syndrome: preclinical validation and first-in-human use
Xu H, Sun L, Wu Z, DeStefano VM, Wada M, Chow JE, Yi H, Wang G, Dai J, Zheng W, Wang T, Zhang W, Song C, Luo J, Ma Y, Waner B, Dong M, Chen H, Qin B, Zhang H, Chang JH, Ma Y, Feng J
Frontiers in Immunology 2025
Translational analysis reveals roles for resident and recruited T cell subsets in drug hypersensitivity reactions varying with reaction type
Pranali Shah, George Romar, Artur Manukyan, Wei-Che Ko, Pei-Chen Hsieh, Gustavo Velasquez, Elisa Schunkert, Xiaopeng Fu, Indira Guleria, Roderick Bronson, Kevin Wei, Abigail Waldman, Frank Vleugels, Marilyn Liang, Anita Giobbie-Hurder, Arash Mostaghimi, Birgitta Schmidt, Victor Barrera, Ruth K. Foreman, Manuel Garber, Sherrie Divito
Journal of Clinical Investigation 2024
Role of IL-4 and IL-13 in Cutaneous T Cell Lymphoma.
Mazzetto R, Miceli P, Tartaglia J, Ciolfi C, Sernicola A, Alaibac M
2024
LAIR1 prevents excess inflammatory tissue damage in S. aureus skin infection and Cutaneous T-cell Lymphoma
Dorando HK, Mutic EC, Tomaszewski KL, Tian L, Stefanov MK, Quinn CC, Veis DJ, Wardenburg JB, Musiek AC, Mehta-Shah N, Payton JE
2024
The Tumor Microenvironment as a Therapeutic Target in Cutaneous T Cell Lymphoma
Kwantwi LB, Rosen ST, Querfeld C
Cancers 2024
Harnessing the immune system in the treatment of cutaneous T cell lymphomas
Fay CJ, Awh KC, LeBoeuf NR, Larocca CA
Frontiers in Oncology 2023
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Peiffer L, Gambichler T, Buus TB, Horny K, Gravemeyer J, Furtmann F, Spassova I, Kubat L, Susok L, Stranzenbach R, Srinivas N, Ødum N, Becker JC
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Mycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression
Dobos G, Lazaridou I, de Masson A
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Potential links between the microbiota and T cell immunity determine the tumor cell fate
Mohseni AH, Taghinezhad-S S, Casolaro V, Lv Z, Li D
Cell Death and Disease 2023
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Mandel J, Gleason L, Joffe D, Bhatti S, Nikbakht N
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Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides.
Yu Z, Vieyra-Garcia P, Benezeder T, Crouch JD, Kim IR, O'Malley JT, Devlin PM, Gehad A, Zhan Q, Gudjonsson JE, Sarkar MK, Kahlenberg JM, Gerard N, Teague JE, Kupper TS, LeBoeuf NR, Larocca C, Tawa M, Pomahac B, Talbot SG, Orgill DP, Wolf P, Clark RA
Journal of Investigative Dermatology 2023
Functional heterogeneity of human skin‐resident memory T cells in health and disease
Strobl J, Haniffa M
Immunological Reviews 2023
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma
X Liu, S Jin, S Hu, R Li, H Pan, Y Liu, P Lai, D Xu, J Sun, Z Liu, Y Gao, Y Zhao, F Liu, Y Xiao, Y Li, Y Wen, Z Chen, B Xu, Y Lin, M Ran, Q Li, S Yang, H Li, P Tu, M Haniffa, S Teichmann, F Bai, Y Wang
Nature Communications 2022
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation
Borges TJ, Abarzua P, Gassen RB, Kollar B, Lima-Filho M, Aoyama BT, Gluhova D, Clark RA, Islam SA, Pomahac B, Murphy GF, Lian CG, Talbot SG, Riella LV
Cell reports. Medicine 2022
CCR8 is a new therapeutic target in cutaneous T-cell lymphomas
Giustiniani J, Dobos G, Moins-Teisserenc H, Eustaquio T, Battistella M, Ortonne N, Ram-Wolff C, Bouaziz JD, Marie-Cardine A, Mourah S, Bagot M, Kupper TS, Clark RA, Bensussan A, de Masson A
Blood Advances 2022
IL-32 supports the survival of malignant T cells in cutaneous T cell lymphoma
Yu KK, Smith NP, Essien SV, Teague JE, Vieyra-Garcia P, Gehad A, Zhan Q, Crouch JD, Gerard N, Larocca C, Wolf P, LeBoeuf NR, Tawa M, Kupper TS, Villani AC, Clark RA
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The British journal of dermatology 2022
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Malignant and Benign T Cells Constituting Cutaneous T-Cell Lymphoma
S Nakai, E Kiyohara, R Watanabe
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