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Citations to this article

Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status
Farhad Ghasemi, … , Paul C. Boutros, Anthony C. Nichols
Farhad Ghasemi, … , Paul C. Boutros, Anthony C. Nichols
Published January 10, 2019
Citation Information: JCI Insight. 2019;4(1):e123443. https://doi.org/10.1172/jci.insight.123443.
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Research Article Genetics Oncology Article has an altmetric score of 5

Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status

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Abstract

Smoking has historically been recognized as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences between heavy smokers (>20 pack years) and never smokers among the HNSCC patients within The Cancer Genome Atlas (TCGA). Single nucleotide variation and copy number aberration differences between heavy smokers and never smokers were compared within human papillomavirus–positive (HPV-positive) (n = 67) and HPV-negative (n = 431) TCGA cohorts with HNSCC, and the impact of these mutations on survival were assessed. No genes were differentially mutated between smoking and never-smoking patients with HPV-positive tumors. By contrast, in HPV-negative tumors, NSD1 and COL1A11 were found to be more frequently mutated in heavy smokers, while CASP8 was more frequently altered in never smokers. HPV-negative patients with NSD1 mutations experienced significantly improved overall survival compared with NSD1 WT patients. This improved prognosis was validated in an independent cohort of 77 oral cavity cancer patients and a meta-analysis that included 2 additional data sets (688 total patients, hazard ratio for death 0.44, 95% CI, 0.30–0.65). NSD1 mutations are more common in HPV-negative heavy smokers, define a cohort with favorable prognosis, and may represent a clinically useful biomarker to guide treatment deintensification for HPV-negative patients.

Authors

Farhad Ghasemi, Stephenie D. Prokopec, Danielle MacNeil, Neil Mundi, Steven F. Gameiro, Christopher Howlett, William Stecho, Paul Plantinga, Nicole Pinto, Kara M. Ruicci, Mohammed Imran Khan, John Yoo, Kevin Fung, Axel Sahovaler, David A. Palma, Eric Winquist, Joe S. Mymryk, John W. Barrett, Paul C. Boutros, Anthony C. Nichols

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 3 1 1 3 5 2 3 18
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (2)

Title and authors Publication Year
Analysis of the TCGA Dataset Reveals that Subsites of Laryngeal Squamous Cell Carcinoma Are Molecularly Distinct
A Sorgini, HA Kim, PY Zeng, MH Shaikh, N Mundi, F Ghasemi, ED Gravio, H Khan, D MacNeil, MI Khan, A Mendez, J Yoo, K Fung, P Lang, DA Palma, JS Mymryk, JW Barrett, KB Patel, PC Boutros, AC Nichols
Cancers 2020
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19
R Bao, K Hernandez, L Huang, JJ Luke
Journal for ImmunoTherapy of Cancer 2020

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