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Renoprotective factor DCXR protects against Chronic Kidney Disease
In this episode, Paul Perco and colleagues show that lower expression of the renoprotective factor DCXR results in a more severe Chronic Kidney Disease.....
Published June 20, 2019
Video Abstracts
Atrial fibrillation initiation linked to action potential duration heterogeneity
In this episode Elaine Wan and colleagues reveal that action potential duration heterogeneity drive initiation and persistence of arrhythmia...
Published June 19, 2019
Video Abstracts
Urinary markers of acute interstitial nephritis
In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis…
Published May 16, 2019
Video Abstracts
MacSpectrum platform decodes macrophage heterogeneity
In this episode, Beiyan Zhou, Chuan Li, and colleagues describe the development and application of single-cell transcriptomics-based MacSpectrum, which enables fine-mapping of monocyte/macrophage heterogeneity in healthy and disease states…
Published May 16, 2019
Video Abstracts
Long-term trial supports CD19-targeted CAR T cells for relapsed/refractory CLL
In this episode, Mark Geyer and colleagues demonstrate that second-generation CD19-targeted CAR T cell therapy following conditioning chemotherapy is tolerated and can produce complete remission in a subset of relapsed/refractory CLL patients...
Published May 13, 2019
Video Abstracts
Ovarian cancer microenvironment promotes suppressor functions in mature neutrophils
In this episode, Kelly Singel and colleagues reveal that mature neutrophils acquire a suppressive phenotype in the ovarian cancer microenvironment that is linked to complement C3 activation…
Published May 6, 2019
Video Abstracts
Complement receptor C3aR1-mediated protection in spinal cord injury
In this episode, Marc Ruitenberg and colleagues demonstrate that complement receptor C3aR stimulates PTEN to inhibit neutrophil-mediated inflammatory pathology following traumatic spinal cord injury…
Published May 2, 2019
Video Abstracts
Extreme immune decline in ART-treated HIV-infected individuals
In this episode, Irini Sereti, Andrea Lisco, and colleagues define a set of HIV-infected patients with extreme immune decline (EXID) despite ART-mediated viral suppression….
Published April 18, 2019
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CD91 on antigen-presenting cells influences response to nascent tumors
In this episode, Robert Binder and colleagues reveal that CD91 expression on antigen-presenting cells sets the stage for early immune response to emerging tumors…
Published April 4, 2019
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Munc18 isoforms play distinct roles in airway mucin secretion
In this episode, Burton Dickey, Ana Jaramillo, and colleagues reveal that specific isoforms of Munc18 have distinct roles in airway mucin secretion…
Published March 21, 2019
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