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Long-term trial supports CD19-targeted CAR T cells for relapsed/refractory CLL
In this episode, Mark Geyer and colleagues demonstrate that second-generation CD19-targeted CAR T cell therapy following conditioning chemotherapy is tolerated and can produce complete remission in a subset of relapsed/refractory CLL patients...
Published May 13, 2019
Video Abstracts
Ovarian cancer microenvironment promotes suppressor functions in mature neutrophils
In this episode, Kelly Singel and colleagues reveal that mature neutrophils acquire a suppressive phenotype in the ovarian cancer microenvironment that is linked to complement C3 activation…
Published May 6, 2019
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Complement receptor C3aR1-mediated protection in spinal cord injury
In this episode, Marc Ruitenberg and colleagues demonstrate that complement receptor C3aR stimulates PTEN to inhibit neutrophil-mediated inflammatory pathology following traumatic spinal cord injury…
Published May 2, 2019
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Extreme immune decline in ART-treated HIV-infected individuals
In this episode, Irini Sereti, Andrea Lisco, and colleagues define a set of HIV-infected patients with extreme immune decline (EXID) despite ART-mediated viral suppression….
Published April 18, 2019
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CD91 on antigen-presenting cells influences response to nascent tumors
In this episode, Robert Binder and colleagues reveal that CD91 expression on antigen-presenting cells sets the stage for early immune response to emerging tumors…
Published April 4, 2019
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Munc18 isoforms play distinct roles in airway mucin secretion
In this episode, Burton Dickey, Ana Jaramillo, and colleagues reveal that specific isoforms of Munc18 have distinct roles in airway mucin secretion…
Published March 21, 2019
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Adaptive optics reveals stability of cellular mosaicism in the eye
In this episode, Johnny Tam and colleagues develop an adaptive optics approach that allows longitudinal assessment of cell mosaicism in the human eye…
Published March 21, 2019
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Isoquercetin reduces coagulation markers in patients at risk of thrombosis
In this episode, Jeffrey Zwicker and colleagues demonstrate that targeting protein disulfide isomerase improves markers of coagulation in patients at risk of thrombosis…
Published February 21, 2019
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Omega-3 fatty acids ameliorate placental inflammation induced by oral bacterium
In this episode, Han Yiping and colleagues reveal how an oral bacterium induces placental inflammation and that omega-3 fatty acid supplementation ameliorates this inflammation…
Published February 7, 2019
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A biomarker signature of treatment-resistant HPV-related cancer
In this episode, Curtis Pickering and colleagues identify a biomarker signature associated with poor treatment response in HPV-positive oropharyngeal squamous cell carcinoma…
Published January 10, 2019
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