Author's Takes

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Quisinostat as a radiosensitizer for the treatment of glioblastoma
In this episode, Costanza Lo Cascio, Artak Tovmasyan, and Shwetal Mehta discuss the identification of a brain-penetrant HDAC inhibitor with radiosensitizing properties for the treatment of glioblastoma...
Published November 22, 2023
Author's Take
Sorting nexin 10 and glioblastoma stem cells via protein sorting
In this episode, Ryan Gimple and colleagues explain that glioblastoma stem cells depend on SNX10, an endosomal protein sorting factor, which maintains cancer cell proliferation and stemness through platelet-derived growth factor receptor signaling...
Published March 22, 2023
Author's Take
Stabilization of E-cadherin adhesions and metastatic breast cancer
In this episode, Kuppusamy Balamurugan and colleagues explain that COX-2 promotes E-Cadherin complex protein expression, and celecoxib in combination with paclitaxel diminishes...
Published March 22, 2023
Author's Take
NLRP3 signaling and preterm labor and birth
In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor...
Published September 2, 2022
Author's Take
Long noncoding RNAs and targetable kinases and glioblastoma radiation resistance
In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations...
Published August 23, 2022
Author's Take
FAM114A1 as a therapeutic target for the treatment of heart disease
In this episode, Peng Yao explains that FAM114A1 modulates cardiac fibrosis by regulating Ang II signaling and pharmacological inhibition of FAM114A1 is a therapeutic strategy for the treatment of heart disease...
Published July 19, 2022
Author's Take
IsoLG adducts play an essential role in systemic lupus erythematosus
In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice...
Published July 6, 2022
Author's Take
Cilia proteins and altered flow in the vasculature
In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process....
Published March 22, 2022
Author's Take
IDH1 mutation, histology, and treatment of tissue metabolites in diffuse glioma
In this episode, Ghazaleh Tabatabai and colleagues discuss the landscape of tissue metabolites and corresponding transcripts in diffuse glioma assessed by NMR metabolomics and RNA sequening...
Published March 9, 2022
Author's Take
Biological processes during term parturition
In this episode, Nardhy Gomez-Lopez explains how single-cell RNA-sequencing reveals the contributions of specific myometrial cell types to the biological processes implicated in term parturition...
Published March 8, 2022
Author's Take
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