Author's Take

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The Women’s Health Initiative and lung cancer in never-smokers
In this episode, Sitapriya Moorthi explains that the genomic landscape of lung cancer in older never-smoker women has unique patterns of mutations but is indistinguishable in its copy number alterations from smokers...
Published November 13, 2024
Author's Take
Preserving kidney function with aldehyde dehydrogenase 2
In this episode, Hsiang-Tsui Wang explains that targeting the interaction between aldehyde dehydrogenase 2 and acrolein, a byproduct of lipid peroxidation, may offer a therapeutic strategy for chronic kidney disease (CKD)...
Published October 8, 2024
Author's Take
Remodeling abnormalities in mitochondrial trifunctional protein deficiency
In this episode, Eduardo Vieira Neto explains that cardiolipin remodeling is deregulated in trifunctional protein deficiency leading to a reduction in mitochondrial oxygen consumption rate that contributes to the pathophysiology of this disease...
Published September 18, 2024
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Murine lupus protection and regulation of TLR7
In this episode Rachael Gordon and Haylee Cosgrove describe how NOX2 deficiency exacerbates lupus but the cell types and mechanisms by which NOX2 exerts protective effects remain unknown...
Published August 22, 2024
Author's Take
Folate treatment for lethal arrhythmias in TANGO2-deficiency disorder
In this episode, Lilei Zhang and Weiyi Xu present data from their iPSC-CM study together with clinical observations that support the use of B-vitamins to mitigate cardiac crises in TANGO2-deficient disorder (TDD) patients...
Published July 25, 2024
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Immune responses to 4CMenB vaccine exhibited in children with perinatally acquired HIV
In this episode, Alessia Neri describes how their study examined 4CMenB vaccine in ART-treated PHIV and healthy controls showing good safety, B cell subsets alteration, and distinct immune signatures in PHIV children...
Published May 22, 2024
Author's Take
Quisinostat as a radiosensitizer for the treatment of glioblastoma
In this episode, Costanza Lo Cascio, Artak Tovmasyan, and Shwetal Mehta discuss the identification of a brain-penetrant HDAC inhibitor with radiosensitizing properties for the treatment of glioblastoma...
Published November 22, 2023
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Sorting nexin 10 and glioblastoma stem cells via protein sorting
In this episode, Ryan Gimple and colleagues explain that glioblastoma stem cells depend on SNX10, an endosomal protein sorting factor, which maintains cancer cell proliferation and stemness through platelet-derived growth factor receptor signaling...
Published March 22, 2023
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Stabilization of E-cadherin adhesions and metastatic breast cancer
In this episode, Kuppusamy Balamurugan and colleagues explain that COX-2 promotes E-Cadherin complex protein expression, and celecoxib in combination with paclitaxel diminishes...
Published March 22, 2023
Author's Take
NLRP3 signaling and preterm labor and birth
In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor...
Published September 2, 2022
Author's Take
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