The Journal of Clinical Investigation
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TRPV4 channels are essential for protection from lung edema
In this episode, Alexander Dietrich and Christian Schremmer explain how TRPV4 is essential for alveolar epithelial function and protects from ischemia-reperfusion induced lung edema...
Published November 30, 2020
Predicting atrial fibrillation after ablation
In this episode, Jasmeet Reyat, Winnie Chua, Larissa Fabritz, and colleagues explain that, building on genomic and experimental findings, low PITX2 in left atrial cardiomyocytes and high BMP10 in plasma predict recurrent AF in patients after ablation...
Published August 31, 2020
C5a impairs phagosomal maturation through phosphoproteomic remodeling
C5a disrupts the neutrophil phosphoproteomic response to bacteria, impairing phagosomal maturation and bacterial killing...
Published August 6, 2020
TSC–associated cystic kidney disease is prevented in pregnancy
In this episode, Oded Volovelsky and colleagues report that rapamycin or dexamethasone administration in pregnancy to a mouse model of tuberous sclerosis complex disease prevents cystic kidney disease in offspring...
Published July 9, 2020
Regulating bile duct epithelial injury in erythroid cells
In this episode, Li Yang and colleagues discuss how hepatic CD71+ erythroid cells play an immunoregulatory role in biliary atresia by suppressing the activation of hepatic lymphocytes...
Published June 4, 2020
Diabetes-associated genetic variation alters insulin secretion
In this Episode, Adrian Vella and colleagues discuss abnormal insulin pulse characteristics in non-diabetic individuals are linked with diabetes-associated variation in TCF7L2 and may serve as early markers of β cell dysfunction...
Published April 9, 2020
Drug delivery platform targets lower airway inflammation
In this episode, Krishnendu Roy, Rabindra Tirouvanziam, Amit Gaggar, and colleagues describe the development of a drug delivery platform that allows direct targeting of lung neutrophils under inflammatory conditions…
Published December 5, 2019
Composite signature for prediction of T1D progression
In this episode, Cate Speake and colleagues employ an analytical method that incorporates reproducibility testing to identify a composite signature prognostic for type 1 diabetes disease progression after diagnosis…
Published December 5, 2019
Itch in the gut
In this episode, Stuart Brierley and colleagues link itch in the gut to nerve sensitization and chronic intestinal pain and provide an animation illustrating the potential clinical implications of this work...
Published October 17, 2019
Detrimental effects of suboptimal hydration
In this episode, Natalia Dmitrieva and colleagues show that improper hydration throughout life associates with several detrimental effects on long-term health...
Published September 5, 2019
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