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Humanized mouse models of MC4R-linked obesity
In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity...
Published March 25, 2021
Aging and T cells during recovery from influenza pneumonia
The age-related pro-repair function of Treg cells following influenza infection is determined by cell-autonomous mechanisms...
Published March 23, 2021
Protection against iatrogenically induced hearing loss
In this episode, Marisa Zallocchi explains how treatment with quinoxaline derivatives protects from aminoglycoside- and cisplatin-hearing loss by NF-kB inhibition...
Published March 11, 2021
Epithelial IL-33 in chronic airway disease
In this episode, Jennifer Alexander-Brett and colleagues explain that epithelial IL-33 co-secretion with exosomes is blocked by inhibitors of the neutral...
Published February 26, 2021
TRPV4 channels are essential for protection from lung edema
In this episode, Alexander Dietrich and Christian Schremmer explain how TRPV4 is essential for alveolar epithelial function and protects from ischemia-reperfusion induced lung edema...
Published November 30, 2020
Predicting atrial fibrillation after ablation
In this episode, Jasmeet Reyat, Winnie Chua, Larissa Fabritz, and colleagues explain that, building on genomic and experimental findings, low PITX2 in left atrial cardiomyocytes and high BMP10 in plasma predict recurrent AF in patients after ablation...
Published August 31, 2020
C5a impairs phagosomal maturation through phosphoproteomic remodeling
C5a disrupts the neutrophil phosphoproteomic response to bacteria, impairing phagosomal maturation and bacterial killing...
Published August 6, 2020
TSC–associated cystic kidney disease is prevented in pregnancy
In this episode, Oded Volovelsky and colleagues report that rapamycin or dexamethasone administration in pregnancy to a mouse model of tuberous sclerosis complex disease prevents cystic kidney disease in offspring...
Published July 9, 2020
Regulating bile duct epithelial injury in erythroid cells
In this episode, Li Yang and colleagues discuss how hepatic CD71+ erythroid cells play an immunoregulatory role in biliary atresia by suppressing the activation of hepatic lymphocytes...
Published June 4, 2020
Diabetes-associated genetic variation alters insulin secretion
In this Episode, Adrian Vella and colleagues discuss abnormal insulin pulse characteristics in non-diabetic individuals are linked with diabetes-associated variation in TCF7L2 and may serve as early markers of β cell dysfunction...
Published April 9, 2020
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American Society for Clinical Investigation
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