Author's Take

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Cilia proteins and altered flow in the vasculature
In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process....
Published March 22, 2022
Author's Take
IDH1 mutation, histology, and treatment of tissue metabolites in diffuse glioma
In this episode, Ghazaleh Tabatabai and colleagues discuss the landscape of tissue metabolites and corresponding transcripts in diffuse glioma assessed by NMR metabolomics and RNA sequening...
Published March 9, 2022
Author's Take
Biological processes during term parturition
In this episode, Nardhy Gomez-Lopez explains how single-cell RNA-sequencing reveals the contributions of specific myometrial cell types to the biological processes implicated in term parturition...
Published March 8, 2022
Author's Take
Protection against preterm birth and fetal inflammatory injury
In this episode, Nardhy Gomez-Lopez explains that macrophages exert anti-inflammatory effects in late gestation, to maintain uterine quiescence and to protect against fetal inflammatory injury that compromises postnatal survival...
Published October 13, 2021
Author's Take
MLK3 mediation and the impact of PKG1α on cardiac function
In this episode, Robert Blanton explains how this paper identifies mixed lineage kinase 3 as a novel PKG1a substrate. MLK3 mediates PKGI therapeutic effects on LV function but regulates blood pressure independently of PKG1...
Published September 22, 2021
Author's Take
Antibodies to vaccine-preventable infections and CAR-T cell therapy
In this episode, Joshua Hill explains that they investigated antibodies to vaccine-preventable infections and other pathogen-specific antibodies in individuals with remission after CAR-T-cell therapy for B-lineage malignancies...
Published June 22, 2021
Author's Take
Regulation of human brown/beige adipocyte lipolysis and thermogenesis
In this episode, Cheryl Cero explains that β3-ARs in human brown/beige adipocytes are required to maintain multiple components of lipolytic and thermogenic cellular machinery and β3-AR agonists could be used to achieve metabolic benefit in humans...
Published June 18, 2021
Author's Take
Base editing in human primary muscle stem cells and mutation repair
In this episode, Helena Escobar and Simone Spuler explain that patient primary muscle stems cells gene repaired with greater than 90% efficiency by base editing maintain their regenerative properties...
Published May 28, 2021
Author's Take
Peptide recognition by T and B cells in rheumatoid arthritis
In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis...
Published April 22, 2021
Author's Take
Humanized mouse models of MC4R-linked obesity
In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity...
Published March 25, 2021
Author's Take
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