The Journal of Clinical Investigation
Resource and Technical Advances
Top read articles
JCI This Month
No articles were found with this tag.
NLRP3 signaling and preterm labor and birth
In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor...
Published September 2, 2022
Long noncoding RNAs and targetable kinases and glioblastoma radiation resistance
In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations...
Published August 23, 2022
FAM114A1 as a therapeutic target for the treatment of heart disease
In this episode, Peng Yao explains that FAM114A1 modulates cardiac fibrosis by regulating Ang II signaling and pharmacological inhibition of FAM114A1 is a therapeutic strategy for the treatment of heart disease...
Published July 19, 2022
IsoLG adducts play an essential role in systemic lupus erythematosus
In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice...
Published July 6, 2022
Cilia proteins and altered flow in the vasculature
In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process....
Published March 22, 2022
IDH1 mutation, histology, and treatment of tissue metabolites in diffuse glioma
In this episode, Ghazaleh Tabatabai and colleagues discuss the landscape of tissue metabolites and corresponding transcripts in diffuse glioma assessed by NMR metabolomics and RNA sequening...
Published March 9, 2022
Biological processes during term parturition
In this episode, Nardhy Gomez-Lopez explains how single-cell RNA-sequencing reveals the contributions of specific myometrial cell types to the biological processes implicated in term parturition...
Published March 8, 2022
Protection against preterm birth and fetal inflammatory injury
In this episode, Nardhy Gomez-Lopez explains that macrophages exert anti-inflammatory effects in late gestation, to maintain uterine quiescence and to protect against fetal inflammatory injury that compromises postnatal survival...
Published October 13, 2021
MLK3 mediation and the impact of PKG1α on cardiac function
In this episode, Robert Blanton explains how this paper identifies mixed lineage kinase 3 as a novel PKG1a substrate. MLK3 mediates PKGI therapeutic effects on LV function but regulates blood pressure independently of PKG1...
Published September 22, 2021
Antibodies to vaccine-preventable infections and CAR-T cell therapy
In this episode, Joshua Hill explains that they investigated antibodies to vaccine-preventable infections and other pathogen-specific antibodies in individuals with remission after CAR-T-cell therapy for B-lineage malignancies...
Published June 22, 2021
Copyright © 2023
American Society for Clinical Investigation
Sign up for email alerts