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A long non-coding RNA marker of isolated human islet quality
In this episode, Wilson Wong, Wayne Hawthorne, Mugdha Joglekar, Anand Hardikar, and colleagues identify a long non-coding RNA signature that is predictive of the quality human cadaver-derived pancreatic islets…
Published August 22, 2019
Author's Take
Enhanced mitochondrial fusion suppresses pancreatic cancer
In this episode, Cullen Taniguchi, Meifang Yu, Nicholas Nguyen, and colleagues demonstrate that enhancing mitochondrial fusion in pancreatic cancer cells alters tumor energetics and correlates with improved survival in mouse model...
Published August 22, 2019
Author's Take
Inner blood-retina barrier dysfunction linked to retina cell atrophy
In this episode, Matthew Campbell, Natalie Hudson, and colleagues show that blood vessels of the inner retina are highly dynamic and that loss of the inner blood-retina barrier integrity may underlie age-related macular degeneration…
Published August 8, 2019
Author's Take
High-salt diet-induced microbiome alterations linked to hypertension
In this episode, Annet Kirabo, Jane Ferguson, and colleagues provide evidence that high-salt diet-induced changes in the gut microbiome promote dendritic cell activation, leading to inflammation and hypertension…
Published August 7, 2019
Author's Take
Persistence of early arising clones of HIV-infected cells in patients
In this episode, John Coffin, Stephen Hughes and colleagues show that clones of HIV-infected cells arise in the first few weeks following infection and can persist even in patients on successful anti-retroviral therapy...
Published July 3, 2019
Author's Take
High-resolution atlas of the human kidney
In this episode, Singh and colleagues use Imaging mass cytometry to generate an atlas of the human kidney at a single-cell resolution.....
Published June 20, 2019
Author's Take
Renoprotective factor DCXR protects against Chronic Kidney Disease
In this episode, Paul Perco and colleagues show that lower expression of the renoprotective factor DCXR results in a more severe Chronic Kidney Disease.....
Published June 20, 2019
Author's Take
Atrial fibrillation initiation linked to action potential duration heterogeneity
In this episode Elaine Wan and colleagues reveal that action potential duration heterogeneity drive initiation and persistence of arrhythmia...
Published June 19, 2019
Author's Take
Urinary markers of acute interstitial nephritis
In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis…
Published May 16, 2019
Author's Take
MacSpectrum platform decodes macrophage heterogeneity
In this episode, Beiyan Zhou, Chuan Li, and colleagues describe the development and application of single-cell transcriptomics-based MacSpectrum, which enables fine-mapping of monocyte/macrophage heterogeneity in healthy and disease states…
Published May 16, 2019
Author's Take
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