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Murine lupus protection and regulation of TLR7
In this episode Rachael Gordon and Haylee Cosgrove describe how NOX2 deficiency exacerbates lupus but the cell types and mechanisms by which NOX2 exerts protective effects remain unknown...
Published August 22, 2024
Video Abstracts
Folate treatment for lethal arrhythmias in TANGO2-deficiency disorder
In this episode, Lilei Zhang and Weiyi Xu present data from their iPSC-CM study together with clinical observations that support the use of B-vitamins to mitigate cardiac crises in TANGO2-deficient disorder (TDD) patients...
Published July 25, 2024
Video Abstracts
Immune responses to 4CMenB vaccine exhibited in children with perinatally acquired HIV
In this episode, Alessia Neri describes how their study examined 4CMenB vaccine in ART-treated PHIV and healthy controls showing good safety, B cell subsets alteration, and distinct immune signatures in PHIV children...
Published May 22, 2024
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Quisinostat as a radiosensitizer for the treatment of glioblastoma
In this episode, Costanza Lo Cascio, Artak Tovmasyan, and Shwetal Mehta discuss the identification of a brain-penetrant HDAC inhibitor with radiosensitizing properties for the treatment of glioblastoma...
Published November 22, 2023
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Sorting nexin 10 and glioblastoma stem cells via protein sorting
In this episode, Ryan Gimple and colleagues explain that glioblastoma stem cells depend on SNX10, an endosomal protein sorting factor, which maintains cancer cell proliferation and stemness through platelet-derived growth factor receptor signaling...
Published March 22, 2023
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Stabilization of E-cadherin adhesions and metastatic breast cancer
In this episode, Kuppusamy Balamurugan and colleagues explain that COX-2 promotes E-Cadherin complex protein expression, and celecoxib in combination with paclitaxel diminishes...
Published March 22, 2023
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NLRP3 signaling and preterm labor and birth
In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor...
Published September 2, 2022
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Long noncoding RNAs and targetable kinases and glioblastoma radiation resistance
In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations...
Published August 23, 2022
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FAM114A1 as a therapeutic target for the treatment of heart disease
In this episode, Peng Yao explains that FAM114A1 modulates cardiac fibrosis by regulating Ang II signaling and pharmacological inhibition of FAM114A1 is a therapeutic strategy for the treatment of heart disease...
Published July 19, 2022
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IsoLG adducts play an essential role in systemic lupus erythematosus
In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice...
Published July 6, 2022
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