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Response to immunotherapy in metastatic urothelial cancer and multimodal integration of blood
In this episode, Davide Croci, Sandra van Wilpe, and Niven Mehra explain that their manuscript predicts clinical benefit to immunotherapy by analyzing combined biomarkers from circulating tumor DNA and immune cell gene expression data in blood...
Published April 16, 2025
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MD-PhD program admissions: application metrics and predicting outcomes
In this episode, Skip Brass and Myles Akabas explain how the results of their manuscript show that none of the applicant metrics, individually or collectively, predict in-program performance...
Published April 8, 2025
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Brain toxicity via kidney injury is potentially linked by quinolinic acid
In this Episode, Kumar Sharma and Afaf Saliba explain the potential link to kidney injury through brain toxicity due to quinolinic acid...
Published March 24, 2025
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Gut inflammation in mice is alleviated by glucose-dependent insulinotropic polypeptide receptor
In this episode, Rola Hammoud explains that the paper demonstrates that activation versus loss of GIP action impacts the extent of experimental gut inflammation in mice...
Published February 10, 2025
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The Women’s Health Initiative and lung cancer in never-smokers
In this episode, Sitapriya Moorthi explains that the genomic landscape of lung cancer in older never-smoker women has unique patterns of mutations but is indistinguishable in its copy number alterations from smokers...
Published November 13, 2024
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Preserving kidney function with aldehyde dehydrogenase 2
In this episode, Hsiang-Tsui Wang explains that targeting the interaction between aldehyde dehydrogenase 2 and acrolein, a byproduct of lipid peroxidation, may offer a therapeutic strategy for chronic kidney disease (CKD)...
Published October 8, 2024
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Remodeling abnormalities in mitochondrial trifunctional protein deficiency
In this episode, Eduardo Vieira Neto explains that cardiolipin remodeling is deregulated in trifunctional protein deficiency leading to a reduction in mitochondrial oxygen consumption rate that contributes to the pathophysiology of this disease...
Published September 18, 2024
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Murine lupus protection and regulation of TLR7
In this episode Rachael Gordon and Haylee Cosgrove describe how NOX2 deficiency exacerbates lupus but the cell types and mechanisms by which NOX2 exerts protective effects remain unknown...
Published August 22, 2024
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Folate treatment for lethal arrhythmias in TANGO2-deficiency disorder
In this episode, Lilei Zhang and Weiyi Xu present data from their iPSC-CM study together with clinical observations that support the use of B-vitamins to mitigate cardiac crises in TANGO2-deficient disorder (TDD) patients...
Published July 25, 2024
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Immune responses to 4CMenB vaccine exhibited in children with perinatally acquired HIV
In this episode, Alessia Neri describes how their study examined 4CMenB vaccine in ART-treated PHIV and healthy controls showing good safety, B cell subsets alteration, and distinct immune signatures in PHIV children...
Published May 22, 2024
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