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Abstract
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized. Here, we show that endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions. Inducible endothelial-specific deletion of
Authors
Panjamaporn Sangwung, Guangjin Zhou, Lalitha Nayak, E. Ricky Chan, Sandeep Kumar, Dong-Won Kang, Rongli Zhang, Xudong Liao, Yuan Lu, Keiki Sugi, Hisashi Fujioka, Hong Shi, Stephanie D. Lapping, Chandra C. Ghosh, Sarah J. Higgins, Samir M. Parikh, Hanjoong Jo, Mukesh K. Jain
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S Qiao, W Zhang, Y Yin, Z Wei, F Chen, J Zhao, X Sun, D Mu, J Xie, B Xu |
Theranostics | 2020 |
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MicroRNA-363-3p serves as a diagnostic biomarker of acute myocardial infarction and regulates vascular endothelial injury by targeting KLF2
C Gao, H Qian, Q Shi, H Zhang |
Cardiovascular diagnosis and therapy | 2020 |
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Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose
R Sadhukhan, J Leung, S Garg, K Krager, A Savenka, A Basnakian, R Pathak |
Scientific Reports | 2020 |
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Taking KLF9 to ‘Cort’ for Crimes Against Metabolism
David Sweet, Liyan Fan, Mukesh Jain |
Journal of Clinical Investigation | 2019 |
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Antiangiogenic VEGF 165 b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease
VC Ganta, M Choi, CR Farber, BH Annex |
Circulation | 2019 |
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Krϋppel-like factors (KLFs) in renal physiology and disease
MJ Rane, Y Zhao, L Cai |
EBioMedicine | 2019 |
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Endothelial Cell Mechano-Metabolomic Coupling to Disease States in the Lung Microvasculature
D Wu, K Birukov |
Frontiers in Bioengineering and Biotechnology | 2019 |
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VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance
Y Yang, B Cha, ZY Motawe, RS Srinivasan, JP Scallan |
Cell Reports | 2019 |
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Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans
GS Sangha, A Busch, A Acuna, AG Berman, EH Phillips, M Trenner, HH Eckstein, L Maegdefessel, CJ Goergen |
Journal of Vascular Research | 2019 |
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The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
C Peghaire, NP Dufton, M Lang, II Salles-Crawley, J Ahnström, V Kalna, C Raimondi, C Pericleous, L Inuabasi, R Kiseleva, VR Muzykantov, JC Mason, GM Birdsey, AM Randi |
Nature Communications | 2019 |
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Targeting Mechanosensitive Transcription Factors in Atherosclerosis
N Niu, S Xu, Y Xu, PJ Little, ZJ |
Trends in Pharmacological Sciences | 2019 |
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Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
DL Hess, MR Kelly-Goss, OA Cherepanova, AT Nguyen, RA Baylis, S Tkachenko, BH Annex, SM Peirce, GK Owens |
Nature Communications | 2019 |
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Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications
M He, TS Huang, S Li, HC Hong, Z Chen, M Martin, X Zhou, HY Huang, SH Su, J Zhang, WT Wang, J Kang, HD Huang, J Zhang, S Chien, JY Shyy |
Arteriosclerosis, thrombosis, and vascular biology | 2019 |
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Pharmacological basis and new insights of resveratrol action in the cardiovascular system
CK Cheng, JY Luo, CW Lau, ZY Chen, XY Tian, Y Huang |
British Journal of Pharmacology | 2019 |
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KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence
JF Denis, MR Diagbouga, F Molica, A Hautefort, T Linnerz, M Watanabe, S Lemeille, JY Bertrand, BR Kwak |
Frontiers in physiology | 2019 |
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Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion
M Tirone, A Giovenzana, A Vallone, P Zordan, M Sormani, PA Nicolosi, R Meneveri, CR Gigliotti, AE Spinelli, R Bocciardi, R Ravazzolo, I Cifola, S Brunelli |
Frontiers in immunology | 2019 |
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Identification of key microRNAs in the carotid arteries of ApoE−/− mice exposed to disturbed flow
X Wang, S Gao, L Dai, Z Wang, H Wu |
Hereditas | 2019 |
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Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium
D Pandey, Y Nomura, MC Rossberg, D Hori, A Bhatta, G Keceli, T Leucker, L Santhanam, LA Shimoda, D Berkowitz, L Romer |
Arteriosclerosis, thrombosis, and vascular biology | 2018 |
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Atheroprone flow enhances the endothelial-to-mesenchymal transition
B Lai, Z Li, M He, Y Wang, L Chen, J Zhang, Y Yang, JY Shyy |
American journal of physiology. Heart and circulatory physiology | 2018 |
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Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta
SL Maas, O Soehnlein, JR Viola |
Frontiers in immunology | 2018 |
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Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential
DR Sweet, L Fan, PN Hsieh, MK Jain |
Frontiers in Cardiovascular Medicine | 2018 |
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Uremic Advanced Glycation End Products and Protein‐Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel‐Like Factor 2
K Saum, B Campos, D CeldranBonafonte, L Nayak, P Sangwung, C Thakar, P RoyChaudhury, AP Owens |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
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The role of monocytosis and neutrophilia in atherosclerosis
DA Chistiakov, AV Grechko, VA Myasoedova, AA Melnichenko, AN Orekhov |
Journal of Cellular and Molecular Medicine | 2018 |
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Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
Y Miao, NE Ajami, TS Huang, FM Lin, CH Lou, YT Wang, S Li, J Kang, H Munkacsi, MR Maurya, S Gupta, S Chien, S Subramaniam, Z Chen |
Nature Communications | 2018 |
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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
MA Lopez-Ramirez, A Pham, R Girard, T Wyseure, P Hale, A Yamashita, J Koskimäki, S Polster, L Saadat, IA Romero, CT Esmon, F Lagarrigue, IA Awad, LO Mosnier, MH Ginsberg |
Blood | 2018 |
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Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation
M Yee, ED Cohen, W Domm, GA Porter, AN McDavid, MA O'Reilly |
American journal of physiology. Lung cellular and molecular physiology | 2018 |
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Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids
SK Sarvestani, SA Signs, V Lefebvre, S Mack, Y Ni, A Morton, ER Chan, X Li, P Fox, A Ting, MF Kalady, M Cruise, J Ashburn, J Stiene, W Lai, D Liska, S Xiang, EH Huang |
Oncotarget | 2018 |
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Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease
Madhumita Basu, Junyi Zhu, Stephanie LaHaye, Uddalak Majumdar, Kai Jiao, Zhe Han, Vidu Garg |
JCI Insight | 2017 |
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Krüppel-like factors and vascular wall homeostasis
Y Fan, H Lu, W Liang, W Hu, J Zhang, YE Chen |
Journal of Molecular Cell Biology | 2017 |
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Systems biology analysis of longitudinal functional response of endothelial cells to shear stress
NE Ajami, S Gupta, MR Maurya, P Nguyen, JY Li, JY Shyy, Z Chen, S Chien, S Subramaniam |
Proceedings of the National Academy of Sciences | 2017 |
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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
MA Lopez-Ramirez, G Fonseca, HA Zeineddine, R Girard, T Moore, A Pham, Y Cao, R Shenkar, BJ Kreuk, F Lagarrigue, J Lawler, CK Glass, IA Awad, MH Ginsberg |
Journal of Experimental Medicine | 2017 |
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Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors
P Sangwung, G Zhou, Y Lu, X Liao, B Wang, SM Mutchler, M Miller, MR Chance, AC Straub, MK Jain |
Vascular medicine (London, England) | 2017 |
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Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic LaminaHighlights
YW Lu, AM Lowery, LY Sun, HA Singer, G Dai, AP Adam, PA Vincent, JJ Schwarz |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
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Suberanilohydroxamic Acid as a Pharmacological Kruppel‐Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis
Y Xu, S Xu, P Liu, M Koroleva, S Zhang, S Si, ZhengJin |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2017 |
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Analysis of region specific gene expression patterns in the heart and systemic responses after experimental myocardial ischemia
M Zimmermann, L Beer, R Ullrich, D Lukovic, E Simader, D Traxler, T Wagner, L Nemec, L Altenburger, A Zuckermann, M Gyöngyösi, HJ Ankersmit, M Mildner |
Oncotarget | 2017 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
