Citations to this article
Panjamaporn Sangwung, … , Hanjoong Jo, Mukesh K. Jain
Published February 23, 2017
Citation Information: JCI Insight. 2017;2(4):e91700. https://doi.org/10.1172/jci.insight.91700.
Citation Information: JCI Insight. 2017;2(4):e91700. https://doi.org/10.1172/jci.insight.91700.
Abstract
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized. Here, we show that endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions. Inducible endothelial-specific deletion of
Authors
Panjamaporn Sangwung, Guangjin Zhou, Lalitha Nayak, E. Ricky Chan, Sandeep Kumar, Dong-Won Kang, Rongli Zhang, Xudong Liao, Yuan Lu, Keiki Sugi, Hisashi Fujioka, Hong Shi, Stephanie D. Lapping, Chandra C. Ghosh, Sarah J. Higgins, Samir M. Parikh, Hanjoong Jo, Mukesh K. Jain
Total citations by year
Citation information
Citations to this article (131)
| Title and authors | Publication | Year |
|---|---|---|
|
Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke
Hansda S, Das H |
Biology | 2025 |
|
High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration
Li Z, Xu Z, Zhu L, Qin T, Ma J, Feng Z, Yue H, Guan Q, Zhou B, Han G, Zhang G, Li C, Jia S, Qiu Q, Hao D, Wang Y, Wang W |
Genome Research | 2025 |
|
Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2.
He J, Blazeski A, Nilanthi U, Menéndez J, Pirani SC, Levic DS, Bagnat M, Singh MK, Raya JG, García-Cardeña G, Torres-Vázquez J |
bioRxiv : the preprint server for biology | 2024 |
|
KLF4 and CD55 expression and function depend on each other
An FQ, Zhou G, Harland MT, Hussain W, Strainic MG, Jain MK, Medof ME |
Frontiers in immunology | 2024 |
|
Hemodynamic Forces and Atherosclerosis: HEG1 at the Center of the Jigsaw Puzzle.
Iruela-Arispe ML |
Circulation | 2024 |
|
Biomechanics-mediated endocytosis in atherosclerosis
Wang J, Xu J, Liu T, Yu C, Xu F, Wang G, Li S, Dai X |
Frontiers in Cardiovascular Medicine | 2024 |
|
Exploring the role of the CapG gene in hypoxia adaptation in Tibetan pigs
Yan F, Wang Y, Wei M, Zhang J, Ye Y, Duan M, Chamba Y, Shang P |
Frontiers in Genetics | 2024 |
|
KLF4 inhibited the senescence-associated secretory phenotype in ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS.
Ding H, Tong J, Lin H, Ping F, Yao T, Ye Z, Chu J, Yuan D, Wang K, Liu X, Chen F |
Aging | 2024 |
|
Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease
Linna-Kuosmanen S, Schmauch E, Galani K, Ojanen J, Boix CA, Örd T, Toropainen A, Singha PK, Moreau PR, Harju K, Blazeski A, Segerstolpe Å, Lahtinen V, Hou L, Kang K, Meibalan E, Agudelo LZ, Kokki H, Halonen J, Jalkanen J, Gunn J, MacRae CA, Hollmén M, Hartikainen JE, Kaikkonen MU, García-Cardeña G, Tavi P, Kiviniemi T, Kellis M |
Cell reports. Medicine | 2024 |
|
Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins
Todtenhaupt P, Kuipers TB, Dijkstra KL, Voortman LM, Franken LA, Spekman JA, Jonkman TH, Groene SG, Roest AA, Haak MC, Verweij ET, van Pel M, Lopriore E, Heijmans BT, van der Meeren LE |
Life science alliance | 2024 |
|
Transcriptional responses of brain endothelium to Plasmodium falciparum patient-derived isolates in vitro
Askonas C, Storm J, Camarda G, Craig A, Pain A |
Microbiology spectrum | 2024 |
|
Role of long noncoding RNAs in diabetes-associated peripheral arterial disease.
Tapia A, Liu X, Malhi NK, Yuan D, Chen M, Southerland KW, Luo Y, Chen ZB |
Cardiovascular Diabetology | 2024 |
|
Trauma promotes heparan sulfate modifications and cleavage that disrupt homeostatic gene expression in microvascular endothelial cells
Richter RP, Odum JD, Margaroli C, Cardenas JC, Zheng L, Tripathi K, Wang Z, Arnold K, Sanderson RD, Liu J, Richter JR |
Frontiers in Cell and Developmental Biology | 2024 |
|
Saving KLF2/4 from γ-protocadherin to reduce vascular inflammation and atherosclerosis.
Park C, Baek KI, Jo H |
Nature cardiovascular research | 2024 |
|
LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses.
Lam F, Leisegang MS, Brandes RP |
International journal of molecular sciences | 2024 |
|
Low Intraocular Pressure Induces Fibrotic Changes in the Trabecular Meshwork and Schlemm's Canal of Sprague Dawley Rats.
Xu L, Zhao Y, Zhang X, Gang X, Han J, Zhou T, Qi B, Song S, Ren R, Liang Y |
Translational vision science & technology | 2024 |
|
Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations.
Pham VC, Rödel CJ, Valentino M, Malinverno M, Paolini A, Münch J, Pasquier C, Onyeogaziri FC, Lazovic B, Girard R, Koskimäki J, Hußmann M, Keith B, Jachimowicz D, Kohl F, Hagelkruys A, Penninger JM, Schulte-Merker S, Awad IA, Hicks R, Magnusson PU, Faurobert E, Pagani M, Abdelilah-Seyfried S |
EMBO molecular medicine | 2024 |
|
Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan
Heo D, Kim AA, Neumann B, Doze VN, Xu YK, Mironova YA, Slosberg J, Goff LA, Franklin RJ, Bergles DE |
bioRxiv | 2024 |
|
Targeting Krüppel-Like Factor 2 as a Novel Therapy for Glomerular Endothelial Cell Injury in Diabetic Kidney Disease
Min L, Chen Y, Liu R, Li Z, Gu L, Mallipattu S, Das B, Lee K, He JC, Zhong F |
Journal of the American Society of Nephrology : JASN | 2024 |
|
Krüppel-like factor 2 is an endoprotective transcription factor in diabetic kidney disease
Min L, Zhong F, Gu L, Lee K, He JC |
American Journal of Physiology - Cell Physiology | 2024 |
|
Long Non-Coding RNA LEENE Promotes Angiogenesis and Ischemic Recovery
Xiaofang Tang, Yingjun Luo, Dongqiang Yuan, Riccardo Calandrelli, Naseeb Kaur Malhi, Kiran Sriram, Yifei Miao, Chih-Hong Lou, Walter Tsark, Alonso Tapia, Aleysha T. Chen, Guangyu Zhang, Daniel Roeth, Markus Kalkum, Zhao V Wang, Shu Chien, Rama Natarajan, John P. Cooke, Sheng Zhong, Zhen Chen |
Journal of Clinical Investigation | 2023 |
|
Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice
Lu H, Yuan P, Ma X, Jiang X, Liu S, Ma C, Philipsen S, Zhang Q, Yang J, Xu F, Zhang C, Zhang Y, Zhang W |
Nature Communications | 2023 |
|
Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes
Samak M, Kues A, Kaltenborn D, Klösener L, Mietsch M, Germena G, Hinkel R |
International journal of molecular sciences | 2023 |
|
Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression.
Song J, Kim SJ, Gollamudi J, Thiagarajan P, Prchal JT |
Blood Advances | 2023 |
|
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions.
Fan Z, Ardicoglu R, Batavia AA, Rust R, von Ziegler L, Waag R, Zhang J, Desgeorges T, Sturman O, Dang H, Weber R, Roszkowski M, Moor AE, Schwab ME, Germain PL, Bohacek J, De Bock K |
Angiogenesis | 2023 |
|
Participation of Krüppel-like Factors in Atherogenesis
Kotlyarov S, Kotlyarova A |
Metabolites | 2023 |
|
Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume.
Lee WJ, Jung KH, Song H, Lee H, Park HE, Koh Y, Choi SY, Park KI |
CNS Neuroscience & Therapeutics | 2023 |
|
Krüppel‐Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non‐Redundant Enhancer Networks
Sweet DR, Padmanabhan R, Liao X, Dashora HR, Tang X, Nayak L, Jain R, De Val S, Vinayachandran V, Jain MK |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2023 |
|
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
George RM, Firulli BA, Podicheti R, Rusch DB, Mannion BJ, Pennacchio LA, Osterwalder M, Firulli AB |
Development (Cambridge, England) | 2023 |
|
Flow-induced reprogramming of endothelial cells in atherosclerosis.
Tamargo IA, Baek KI, Kim Y, Park C, Jo H |
Nature reviews. Cardiology | 2023 |
|
Altered Hippocampal and Striatal Expression of Endothelial Markers and VIP/PACAP Neuropeptides in a Mouse Model of Systemic Lupus Erythematosus.
Lee J, Thomas Broome S, Jansen MI, Mandwie M, Logan GJ, Marzagalli R, Musumeci G, Castorina A |
International journal of molecular sciences | 2023 |
|
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis.
Chakraborty S, Singh A, Wang L, Wang X, Sanborn MA, Ye Z, Maienschein-Cline M, Mukhopadhyay A, Ganesh BB, Malik AB, Rehman J |
Journal of Experimental Medicine | 2023 |
|
Modulation of lncRNA links endothelial glycocalyx to vascular dysfunction of tyrosine kinase inhibitor
Nukala SB, Jousma J, Yan G, Han Z, Kwon Y, Cho Y, Liu C, Gagnon K, Pinho S, Rehman J, Shao NY, Ong SB, Lee WH, Ong SG |
Cardiovascular Research | 2023 |
|
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses
Chen F, Zhan J, Liu M, Mamun AA, Huang S, Tao Y, Zhao J, Zhang Y, Xu Y, He Z, Du S, Lu W, Li X, Chen Z, Xiao J |
International journal of biological sciences | 2023 |
|
A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions
Fonseca CG, Silvério V, Barata D, Giese W, Gerhardt H, Cardoso S, Franco CA |
Microsystems & Nanoengineering | 2023 |
|
Reprogramming endothelial and vascular smooth muscle cells to prevent and treat hypertension
Pernomian L, Tan W, McCarthy C, Wenceslau CF |
Medical Hypotheses | 2023 |
|
Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia
Albogami S |
Pharmacogenomics and Personalized Medicine | 2023 |
|
Increased transferrin protects from thrombosis in Chuvash erythrocytosis
Shah BN, Zhang X, Sergueeva AI, Miasnikova GY, Ganz T, Prchal JT, Gordeuk VR |
American Journal of Hematology | 2023 |
|
Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2‐LIN28B‐ELK3 Signaling
Yang K, Cui S, Wang J, Xu T, Du H, Yue H, Ye H, Guo J, Zhang J, Li P, Guo Y, Pan C, Pang J, Wang J, Yu X, Zhang C, Liu Z, Chen Y, Xu F |
Advanced Science | 2023 |
|
Engineering microvascular networks using a KLF2 reporter to probe flow-dependent endothelial cell function
Blazeski A, Floryan MA, Fajardo-Ramírez OR, Meibalan E, Ortiz-Urbina J, Angelidakis E, Shelton SE, Kamm RD, García-Cardeña G |
2023 | |
|
Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development.
Baek KI, Ryu K |
Journal of Cardiovascular Translational Research | 2023 |
|
HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells.
Tamargo IA, Baek KI, Xu C, Kang DW, Kim Y, Andueza A, Williams D, Demos C, Villa-Roel N, Kumar S, Park C, Choi R, Johnson J, Chang S, Kim P, Tan S, Jeong K, Tsuji S, Jo H |
Circulation | 2023 |
|
Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated vascular permeability and angiogenesis in breast cancer
Huan Zeng, Yixuan Hou, Rui Wang, Haojun Luo, Yan Sun, Xueying Wan, Taixian Yuan, Yongcan Liu, Rui Tang, Shaojie Cheng, Xinyue Zhou, Ming Xu, Manran Liu |
Theranostics | 2022 |
|
Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy
E Bae, M Yu, J Moon, J Kim, S Lee, S Han, D Park, Y Kim, S Yang |
Cells | 2022 |
|
Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo
C Yeh, S Cheng, Y Lin, T Shentu, R Huang, J Zhu, Y Chen, S Kumar, M Lin, H Kao, P Huang, E Roselló-Sastre, F Garcia, H Jo, Y Fang, K Yang |
Science Advances | 2022 |
|
Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites
R Tsaryk, N Yucel, E Leonard, N Diaz, O Bondareva, M Odenthal-Schnittler, Z Arany, J Vaquerizas, H Schnittler, A Siekmann |
Scientific Reports | 2022 |
|
Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease
D Santovito, C Weber |
Nature Reviews Cardiology | 2022 |
|
Uncovering emergent phenotypes in endothelial cells by clustering of surrogates of cardiovascular risk factors
I Pinheiro-de-Sousa, M Fonseca-Alaniz, S Teixeira, M Rodrigues, J Krieger |
Scientific Reports | 2022 |
|
A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice
N López-Sánchez, M Ramón-Landreau, C Trujillo, A Garrido-García, J Frade |
Molecular Neurobiology | 2022 |
|
Neurorescuing effect of Cinacalcet against hypercalcemia-induced nerve injury in chronic kidney disease via TRAF2/cIAP1/KLF2/SERPINA3 signal axis
Y Cao, Y Xiong, H Sun, Z Wang |
Cell Biology and Toxicology | 2022 |
|
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis
Yang Y, Mumau M, Tober J, Zhu Q, Bennett L, Hong C, Sung D, Keller T, Uzun Y, Gao P, Shewale S, Chen M, Yang J, Chen X, Thomas SA, Tan K, Speck NA, Kahn ML |
Blood | 2022 |
|
Stimulatory G-Protein α Subunit Modulates Endothelial Cell Permeability Through Regulation of Plasmalemma Vesicle-Associated Protein
He L, Lu H, Ji X, Chu J, Qin X, Chen M, Weinstein LS, Gao J, Yang J, Zhang Q, Zhang C, Zhang W |
Frontiers in pharmacology | 2022 |
|
KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress
Moonen JR, Chappell J, Shi M, Shinohara T, Li D, Mumbach MR, Zhang F, Nair RV, Nasser J, Mai DH, Taylor S, Wang L, Metzger RJ, Chang HY, Engreitz JM, Snyder MP, Rabinovitch M |
Nature Communications | 2022 |
|
Immune Function of Endothelial Cells: Evolutionary Aspects, Molecular Biology and Role in Atherogenesis.
Kotlyarov S |
International journal of molecular sciences | 2022 |
|
Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics.
Huo R, Wang J, Sun YF, Weng JC, Li H, Jiao YM, Xu HY, Zhang JZ, Zhao SZ, He QH, Wang S, Zhao JZ, Cao Y |
Frontiers in neurology | 2022 |
|
Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications
Caliceti C, Malaguti M, Marracino L, Barbalace MC, Rizzo P, Hrelia S |
Antioxidants | 2022 |
|
Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior
Abello J, Raghavan S, Yien YY, Stratman AN |
The Journal of biological chemistry | 2022 |
|
Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells
Demos C, Johnson J, Andueza A, Park C, Kim Y, Villa-Roel N, Kang DW, Kumar S, Jo H |
Frontiers in Cardiovascular Medicine | 2022 |
|
Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway
Kobayashi S, Kita S, Okuzaki D, Fujishima Y, Otsuki M, Kato H, Nishizawa Y, Miyashita K, Yokoyama C, Fukuhara A, Morii E, Shimomura I |
iScience | 2022 |
|
A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence
Mastej V, Axen C, Wary A, Minshall RD, Wary KK |
Frontiers in Cell and Developmental Biology | 2022 |
|
Systemic Inflammation Causes Microglial Dysfunction With a Vascular AD phenotype
Bathini P, Dupanloup I, Zenaro E, Terrabuio E, Fischer A, Ballabani E, Doucey MA, Alberi L |
2022 | |
|
Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis
Gomez-Salinero JM, Itkin T, Houghton S, Badwe C, Lin Y, Kalna V, Dufton N, Peghaire CR, Yokoyama M, Wingo M, Lu TM, Li G, Xiang JZ, Hsu YM, Redmond D, Schreiner R, Birdsey GM, Randi AM, Rafii S |
2022 | |
|
PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1
S Kant, KV Tran, M Kvandova, AD Caliz, HJ Yoo, H Learnard, AC Dolan, SM Craige, JD Hall, JM Jiménez, CS Hilaire, E Schulz, S Kröller-Schön, JF Keaney |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
|
Phenotypic diversity and metabolic specialization of renal endothelial cells
SJ Dumas, E Meta, M Borri, Y Luo, X Li, TJ Rabelink, P Carmeliet |
Nature Reviews Nephrology | 2021 |
|
MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program
YW Lu, N Martino, BD Gerlach, JM Lamar, PA Vincent, AP Adam, JJ Schwarz |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
|
Single-Cell Transcriptomics Reveals Endothelial Plasticity During Diabetic Atherogenesis
G Zhao, H Lu, Y Liu, Y Zhao, T Zhu, MT Garcia-Barrio, YE Chen, J Zhang |
Frontiers in Cell and Developmental Biology | 2021 |
|
The MEK5/ERK5 Pathway in Health and Disease
R Paudel, L Fusi, M Schmidt |
International journal of molecular sciences | 2021 |
|
Safeguarding the Vasculature: Redundant Transcriptional Machinery Ensures Endothelial Protection
DR Sweet, MK Jain |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
|
Evolutionary Protection of Krüppel-Like Factors 2 and 4 in the Development of the Mature Hemovascular System
DR Sweet, C Lam, MK Jain |
Frontiers in Cardiovascular Medicine | 2021 |
|
Epigenetic Regulation of the Vascular Endothelium by Angiogenic LncRNAs
N Subramaniam, R Nair, PA Marsden |
Frontiers in Genetics | 2021 |
|
Suprabasin—A Review
M Pribyl, Z Hodny, I Kubikova |
Genes & development | 2021 |
|
Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions
MR Maurya, S Gupta, JY Li, NE Ajami, ZB Chen, JY Shyy, S Chien, S Subramaniam |
Proceedings of the National Academy of Sciences | 2021 |
|
Molecular Diversity of Clinically Stable Human Kidney Allografts
D Rychkov, S Sur, M Sirota, MM Sarwal |
2021 | |
|
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke
C Wang, J Dong, J Sun, S Huang, F Wu, X Zhang, D Pang, Y Fu, L Li |
Molecular Therapy — Nucleic Acids | 2021 |
|
Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3
Q Yuan, A Basit, W Liang, R Qu, Y Luan, C Ren, A Li, X Xu, X Liu, C Yang, A Kuo, R Pierce, L Zhang, B Turk, X Hu, F Li, W Cui, R Li, D Huang, L Mo, WC Sessa, PJ Lee, Y Kluger, B Su, W Tang, J He, D Wu |
Science Translational Medicine | 2021 |
|
Intermittent High Glucose Elevates Nuclear Localization of EZH2 to Cause H3K27me3-Dependent Repression of KLF2 Leading to Endothelial Inflammation
S Thakar, YT Katakia, SK Ramakrishnan, NP Thakkar, S Majumder |
Cells | 2021 |
|
The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction
S Xu, Y Liu, Y Ding, S Luo, X Zheng, X Wu, Z Liu, I Ilyas, S Chen, S Han, PJ Little, MK Jain, J Weng |
Signal Transduction and Targeted Therapy | 2021 |
|
miR-15b-3p promotes the malignant progression of endometrial cancer cells through targeting KLF2
P Wang, X Zhao, X Wu, G Tang, L Yuan |
Cell cycle (Georgetown, Tex.) | 2021 |
|
Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape
F Fortini, FV Sega, L Marracino, P Severi, C Rapezzi, P Rizzo, R Ferrari |
Biomedicines | 2021 |
|
Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling
H Li, Y Wang, J Liu, X Chen, Y Duan, X Wang, Y Shen, Y Kuang, T Zhuang, B Tomlinson, P Chan, Z Yu, Y Cheng, L Zhang, Z Liu, Y Zhang, Z Zhao, Q Zhang, J Liu |
Theranostics | 2021 |
|
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
HA Sindi, G Russomanno, S Satta, VB Abdul-Salam, KB Jo, B Qazi-Chaudhry, AJ Ainscough, R Szulcek, HJ Bogaard, CC Morgan, SS Pullamsetti, MM Alzaydi, CJ Rhodes, R Piva, CA Eichstaedt, E Grünig, MR Wilkins, B Wojciak-Stothard |
Nature Communications | 2020 |
|
Post-translational modifications of S1PR1 and endothelial barrier regulation
M Anwar, D Mehta |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2020 |
|
Nitrite attenuates mitochondrial impairment and vascular permeability induced by ischemia-reperfusion injury in the lung
A Kumar, K Noda, B Philips, M Velayutham, DB Stolz, MT Gladwin, S Shiva, J DCunha |
American journal of physiology. Lung cellular and molecular physiology | 2020 |
|
Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment
AN Stratman, MC Burns, OM Farrelly, AE Davis, W Li, VN Pham, D Castranova, JJ Yano, LM Goddard, O Nguyen, MV Galanternik, TJ Bolan, ML Kahn, Y Mukouyama, BM Weinstein |
2020 | |
|
Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2
D Rolph, H Das |
Frontiers in immunology | 2020 |
|
Signalling through cerebral cavernous malformation protein networks
VL Su, DA Calderwood |
Open Biology | 2020 |
|
Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells
M Noura, K Morita, H Kiyose, H Matsuo, Y Nishinaka-Arai, M Kurokawa, Y Kamikubo, S Adachi |
Scientific Reports | 2020 |
|
Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study
A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, H Jo |
Cell Reports | 2020 |
|
Flow-Induced Transcriptomic Remodeling of Endothelial Cells Derived From Human Induced Pluripotent Stem Cells
E Helle, M Ampuja, L Antola, R Kivelä |
Frontiers in physiology | 2020 |
|
KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism
J Maity, M Deb, C Greene, H Das |
Redox Biology | 2020 |
|
β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression
V Tajadura, MH Hansen, J Smith, H Charles, M Rickman, K Farrell-Dillon, V Claro, C Warboys, A Ferro |
Cell Death and Disease | 2020 |
|
Silence of miR-32-5p promotes endothelial cell viability by targeting KLF2 and serves as a diagnostic biomarker of acute myocardial infarction
Y Dai, T Yan, Y Gao |
Diagnostic Pathology | 2020 |
|
Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages
J Lotto, S Drissler, R Cullum, W Wei, M Setty, EM Bell, SC Boutet, S Nowotschin, YY Kuo, V Garg, D Peer, DM Church, AK Hadjantonakis, PA Hoodless |
Cell | 2020 |
|
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke
X Zhang, L Wang, Z Han, J Dong, D Pang, Y Fu, L Li |
Journal of Neuroinflammation | 2020 |
|
Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression
OH Lee, YM Woo, S Moon, J Lee, H Park, H Jang, YY Park, SK Bae, KH Park, JH Heo, Y Choi |
Aging | 2020 |
|
Extracellular vesicles derived from Krüppel-Like Factor 2-overexpressing endothelial cells attenuate myocardial ischemia-reperfusion injury by preventing Ly6C high monocyte recruitment
S Qiao, W Zhang, Y Yin, Z Wei, F Chen, J Zhao, X Sun, D Mu, J Xie, B Xu |
Theranostics | 2020 |
|
MicroRNA-363-3p serves as a diagnostic biomarker of acute myocardial infarction and regulates vascular endothelial injury by targeting KLF2
C Gao, H Qian, Q Shi, H Zhang |
Cardiovascular diagnosis and therapy | 2020 |
|
Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose
R Sadhukhan, J Leung, S Garg, K Krager, A Savenka, A Basnakian, R Pathak |
Scientific Reports | 2020 |
|
Taking KLF9 to ‘Cort’ for Crimes Against Metabolism
David Sweet, Liyan Fan, Mukesh Jain |
Journal of Clinical Investigation | 2019 |
|
Antiangiogenic VEGF 165 b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease
VC Ganta, M Choi, CR Farber, BH Annex |
Circulation | 2019 |
|
Krϋppel-like factors (KLFs) in renal physiology and disease
MJ Rane, Y Zhao, L Cai |
EBioMedicine | 2019 |
|
Endothelial Cell Mechano-Metabolomic Coupling to Disease States in the Lung Microvasculature
D Wu, K Birukov |
Frontiers in Bioengineering and Biotechnology | 2019 |
|
VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance
Y Yang, B Cha, ZY Motawe, RS Srinivasan, JP Scallan |
Cell Reports | 2019 |
|
Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans
GS Sangha, A Busch, A Acuna, AG Berman, EH Phillips, M Trenner, HH Eckstein, L Maegdefessel, CJ Goergen |
Journal of Vascular Research | 2019 |
|
The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
C Peghaire, NP Dufton, M Lang, II Salles-Crawley, J Ahnström, V Kalna, C Raimondi, C Pericleous, L Inuabasi, R Kiseleva, VR Muzykantov, JC Mason, GM Birdsey, AM Randi |
Nature Communications | 2019 |
|
Targeting Mechanosensitive Transcription Factors in Atherosclerosis
N Niu, S Xu, Y Xu, PJ Little, ZJ |
Trends in Pharmacological Sciences | 2019 |
|
Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
DL Hess, MR Kelly-Goss, OA Cherepanova, AT Nguyen, RA Baylis, S Tkachenko, BH Annex, SM Peirce, GK Owens |
Nature Communications | 2019 |
|
Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications
M He, TS Huang, S Li, HC Hong, Z Chen, M Martin, X Zhou, HY Huang, SH Su, J Zhang, WT Wang, J Kang, HD Huang, J Zhang, S Chien, JY Shyy |
Arteriosclerosis, thrombosis, and vascular biology | 2019 |
|
Pharmacological basis and new insights of resveratrol action in the cardiovascular system
CK Cheng, JY Luo, CW Lau, ZY Chen, XY Tian, Y Huang |
British Journal of Pharmacology | 2019 |
|
KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence
JF Denis, MR Diagbouga, F Molica, A Hautefort, T Linnerz, M Watanabe, S Lemeille, JY Bertrand, BR Kwak |
Frontiers in physiology | 2019 |
|
Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion
M Tirone, A Giovenzana, A Vallone, P Zordan, M Sormani, PA Nicolosi, R Meneveri, CR Gigliotti, AE Spinelli, R Bocciardi, R Ravazzolo, I Cifola, S Brunelli |
Frontiers in immunology | 2019 |
|
Identification of key microRNAs in the carotid arteries of ApoE−/− mice exposed to disturbed flow
X Wang, S Gao, L Dai, Z Wang, H Wu |
Hereditas | 2019 |
|
Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium
D Pandey, Y Nomura, MC Rossberg, D Hori, A Bhatta, G Keceli, T Leucker, L Santhanam, LA Shimoda, D Berkowitz, L Romer |
Arteriosclerosis, thrombosis, and vascular biology | 2018 |
|
Atheroprone flow enhances the endothelial-to-mesenchymal transition
B Lai, Z Li, M He, Y Wang, L Chen, J Zhang, Y Yang, JY Shyy |
American journal of physiology. Heart and circulatory physiology | 2018 |
|
Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta
SL Maas, O Soehnlein, JR Viola |
Frontiers in immunology | 2018 |
|
Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential
DR Sweet, L Fan, PN Hsieh, MK Jain |
Frontiers in Cardiovascular Medicine | 2018 |
|
Uremic Advanced Glycation End Products and Protein‐Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel‐Like Factor 2
K Saum, B Campos, D CeldranBonafonte, L Nayak, P Sangwung, C Thakar, P RoyChaudhury, AP Owens |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
|
The role of monocytosis and neutrophilia in atherosclerosis
DA Chistiakov, AV Grechko, VA Myasoedova, AA Melnichenko, AN Orekhov |
Journal of Cellular and Molecular Medicine | 2018 |
|
Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
Y Miao, NE Ajami, TS Huang, FM Lin, CH Lou, YT Wang, S Li, J Kang, H Munkacsi, MR Maurya, S Gupta, S Chien, S Subramaniam, Z Chen |
Nature Communications | 2018 |
|
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
MA Lopez-Ramirez, A Pham, R Girard, T Wyseure, P Hale, A Yamashita, J Koskimäki, S Polster, L Saadat, IA Romero, CT Esmon, F Lagarrigue, IA Awad, LO Mosnier, MH Ginsberg |
Blood | 2018 |
|
Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation
M Yee, ED Cohen, W Domm, GA Porter, AN McDavid, MA O'Reilly |
American journal of physiology. Lung cellular and molecular physiology | 2018 |
|
Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids
SK Sarvestani, SA Signs, V Lefebvre, S Mack, Y Ni, A Morton, ER Chan, X Li, P Fox, A Ting, MF Kalady, M Cruise, J Ashburn, J Stiene, W Lai, D Liska, S Xiang, EH Huang |
Oncotarget | 2018 |
|
Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease
Madhumita Basu, Junyi Zhu, Stephanie LaHaye, Uddalak Majumdar, Kai Jiao, Zhe Han, Vidu Garg |
JCI Insight | 2017 |
|
Krüppel-like factors and vascular wall homeostasis
Y Fan, H Lu, W Liang, W Hu, J Zhang, YE Chen |
Journal of Molecular Cell Biology | 2017 |
|
Systems biology analysis of longitudinal functional response of endothelial cells to shear stress
NE Ajami, S Gupta, MR Maurya, P Nguyen, JY Li, JY Shyy, Z Chen, S Chien, S Subramaniam |
Proceedings of the National Academy of Sciences | 2017 |
|
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
MA Lopez-Ramirez, G Fonseca, HA Zeineddine, R Girard, T Moore, A Pham, Y Cao, R Shenkar, BJ Kreuk, F Lagarrigue, J Lawler, CK Glass, IA Awad, MH Ginsberg |
Journal of Experimental Medicine | 2017 |
|
Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors
P Sangwung, G Zhou, Y Lu, X Liao, B Wang, SM Mutchler, M Miller, MR Chance, AC Straub, MK Jain |
Vascular medicine (London, England) | 2017 |
|
Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic LaminaHighlights
YW Lu, AM Lowery, LY Sun, HA Singer, G Dai, AP Adam, PA Vincent, JJ Schwarz |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
|
Suberanilohydroxamic Acid as a Pharmacological Kruppel‐Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis
Y Xu, S Xu, P Liu, M Koroleva, S Zhang, S Si, ZhengJin |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2017 |
|
Analysis of region specific gene expression patterns in the heart and systemic responses after experimental myocardial ischemia
M Zimmermann, L Beer, R Ullrich, D Lukovic, E Simader, D Traxler, T Wagner, L Nemec, L Altenburger, A Zuckermann, M Gyöngyösi, HJ Ankersmit, M Mildner |
Oncotarget | 2017 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
