Go to The Journal of Clinical Investigation
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Transfers
  • Advertising
  • Job board
  • Contact
  • Physician-Scientist Development
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Immunology
    • Metabolism
    • Nephrology
    • Oncology
    • Pulmonology
    • All ...
  • Videos
  • Collections
    • In-Press Preview
    • Resource and Technical Advances
    • Clinical Research and Public Health
    • Research Letters
    • Editorials
    • Perspectives
    • Physician-Scientist Development
    • Reviews
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • In-Press Preview
  • Resource and Technical Advances
  • Clinical Research and Public Health
  • Research Letters
  • Editorials
  • Perspectives
  • Physician-Scientist Development
  • Reviews
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Transfers
  • Advertising
  • Job board
  • Contact

Citations to this article

Distinct activation thresholds of human conventional and innate-like memory T cells
Chloe K. Slichter, … , Raphael Gottardo, Martin Prlic
Chloe K. Slichter, … , Raphael Gottardo, Martin Prlic
Published June 2, 2016
Citation Information: JCI Insight. 2016;1(8):e86292. https://doi.org/10.1172/jci.insight.86292.
View: Text | PDF
Research Article Immunology Inflammation Article has an altmetric score of 3

Distinct activation thresholds of human conventional and innate-like memory T cells

  • Text
  • PDF
Abstract

Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B. To better understand each subset’s unique contributions to immunity and pathology, we interrogated inflammation- and TCR-driven activation requirements using human memory CD8+ T and MAIT cells isolated from blood and mucosal tissue biopsies in ex vivo functional assays and single cell gene expression experiments. We found that MAIT cells had a robust IFN-γ and granzyme B response to inflammatory signals but limited responsiveness when stimulated directly via their TCR. Importantly, this is not due to an overall hyporesponsiveness to TCR signals. When delivered together, TCR and inflammatory signals synergize to elicit potent effector function in MAIT cells. This unique control of effector function allows MAIT cells to respond to the same TCR signal in a dichotomous and situation-specific manner. We propose that this could serve to prevent responses to antigen in noninflamed healthy mucosal tissue, while maintaining responsiveness and great sensitivity to inflammation-eliciting infections. We discuss the implications of these findings in context of inflammation-inducing damage to tissues such as BM transplant conditioning or HIV infection.

Authors

Chloe K. Slichter, Andrew McDavid, Hannah W. Miller, Greg Finak, Brenda J. Seymour, John P. McNevin, Gabriela Diaz, Julie L. Czartoski, M. Juliana McElrath, Raphael Gottardo, Martin Prlic

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 Total
Citations: 6 6 8 5 13 18 8 13 7 2 86
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (86)

Title and authors Publication Year
Liver transplant-facilitated recovery of MAIT cell from dysregulation in liver failure demonstrates clinical benefits
wei wang, Chen Dai, Peng Zhu, Mi Wu, hao zhang, qing wei, ting zhou, Xiaosheng Tan, ying jiang, xue cheng, Zhihui Liang, Xiongwen Wu, Zhishui Chen, Xiufang Weng
Nature communications 2025
Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu
Boulouis C, Mouchtaridi E, Müller TR, Mak JY, Fairlie DP, Bergman P, Michaëlsson J, Halfvarson J, Mjösberg J, Buggert M, Sandberg JK
Proceedings of the National Academy of Sciences of the United States of America 2025
Innateness transcriptome gradients characterize mouse T lymphocyte populations
Ascui G, Cedillo-Castelan V, Mendis A, Phung E, Liu HY, Verstichel G, Chandra S, Murray MP, Luna C, Cheroutre H, Kronenberg M
The Journal of Immunology Author Choice 2025
Herpes simplex virus type 1 impairs mucosal-associated invariant T cells.
Stern L, Emanuel Z, Traves R, Willis K, Purohit SK, Samer C, Mak JYW, Fairlie DP, Tscharke DC, Corbett AJ, Abendroth A, Slobedman B
mBio 2025
Understanding Liver Transplantation Outcomes Through the Lens of Its Tissue-resident Immunobiome.
Prosser AC, Klenerman P, Lucas M
Transplantation 2025
The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes.
Fraser DR, Stadnyk AW
Frontiers in immunology 2025
Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection
Samer C, McWilliam HE, McSharry BP, Velusamy T, Burchfield JG, Stanton RJ, Tscharke DC, Rossjohn J, Villadangos JA, Abendroth A, Slobedman B
iScience 2024
Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions.
Ryan EK, Clutter C, De Barra C, Jenkins BJ, O'Shaughnessy S, Ryan OK, McKenna C, Heneghan HM, Walsh F, Finlay DK, Sinclair LV, Jones N, Leung DT, O'Shea D, Hogan AE
Journal of immunology (Baltimore, Md. : 1950) 2024
A Comprehensive Investigation of Stimulatory Agents on MAIT and Vα7.2+/CD161− T Cell Response and Effects of Immunomodulatory Drugs
Singh P, Száraz-Széles M, Baráth S, Hevessy Z
International journal of molecular sciences 2024
Insights into the tissue repair features of MAIT cells
Gao M, Zhao X
Frontiers in immunology 2024
Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus–mediated disruption of the nonclassical MHC class I–related molecule MR1
Samer C, McWilliam HE, McSharry BP, Burchfield JG, Stanton RJ, Rossjohn J, Villadangos JA, Abendroth A, Slobedman B
The Journal of Biological Chemistry 2024
Signals that control MAIT cell function in healthy and inflamed human tissues.
Konecny AJ, Huang Y, Setty M, Prlic M
Immunological reviews 2024
Enhancing CAR-T cell functionality in a patient-specific manner
Zhang DK, Adu-Berchie K, Iyer S, Liu Y, Cieri N, Brockman JM, Neuberg D, Wu CJ, Mooney DJ
Nature Communications 2023
Classic costimulatory interactions in MAIT cell responses: from gene expression to immune regulation
Wang NI, Ninkov M, Haeryfar SM
Clinical & Experimental Immunology 2023
Fine-Tuning through Generations: Advances in Structure and Production of CAR-T Therapy
Zheng Z, Li S, Liu M, Chen C, Zhang L, Zhou D
Cancers 2023
The Emerging Role of MAIT Cell Responses in Viral Infections.
Sandberg JK, Leeansyah E, Eller MA, Shacklett BL, Paquin-Proulx D
Journal of immunology (Baltimore, Md. : 1950) 2023
Transcriptomic profile of TNF(high) MAIT cells is linked to B cell response following SARS-CoV-2 vaccination.
Marzano P, Balin S, Terzoli S, Della Bella S, Cazzetta V, Piazza R, Sandrock I, Ravens S, Tan L, Prinz I, Calcaterra F, Di Vito C, Cancellara A, Calvi M, Carletti A, Franzese S, Frigo A, Darwish A, Voza A, Mikulak J, Mavilio D
Frontiers in immunology 2023
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity.
Garner LC, Amini A, FitzPatrick MEB, Lett MJ, Hess GF, Filipowicz Sinnreich M, Provine NM, Klenerman P
Nature Immunology 2023
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts
Gray EH, Srenathan U, Durham LE, Lalnunhlimi S, Steel KJ, Catrina A, Kirkham BW, Taams LS
Clinical & Experimental Immunology 2023
MAIT cells in bacterial infectious diseases: heroes, villains, or both?
Wu S, Yang X, Lou Y, Xiao X
Clinical & Experimental Immunology 2023
Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation
C Vorkas, C Krishna, K Li, J Aubé, D Fitzgerald, L Mazutis, C Leslie, M Glickman
Journal of immunology (Baltimore, Md. : 1950) 2022
Mining the multifunction of mucosal-associated invariant T cells in hematological malignancies and transplantation immunity: A promising hexagon soldier in immunomodulatory
Gao MG, Zhao XS
Frontiers in immunology 2022
Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive.
Meermeier EW, Zheng CL, Tran JG, Soma S, Worley AH, Weiss DI, Modlin RL, Swarbrick G, Karamooz E, Khuzwayo S, Wong EB, Gold MC, Lewinsohn DM
2022
Mucosal-associated invariant T cells for cancer immunotherapy
Li YR, Zhou K, Wilson M, Kramer A, Zhu Y, Dawson N, Yang L
Molecular Therapy 2022
Soluble factors from TLR4- or TCR-activated cells contribute to stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells.
Ruelas-Galindo I, Huerta L
Immunologic research 2022
Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR-redirection
Tiphaine Parrot, Katie Healy, Caroline Boulouis, Michał J. Sobkowiak, Edwin Leeansyah, Soo Aleman, Antonio Bertoletti, Margaret Sällberg Chen, Johan K. Sandberg
JCI Insight 2021
Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells
Nicholas J. Maurice, Jacqueline Berner, Alexis K. Taber, Dietmar Zehn, Martin Prlic
JCI Insight 2021
Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients
W Rodin, P Sundström, F Ahlmanner, L Szeponik, KK Zajt, Y Wettergren, EB Lindskog, MQ Järbrink
Cancer Immunology, Immunotherapy 2021
Title of article: Mucosal-associated invariant T cells in lung diseases
X Wen, X Zhang, S Nian, G Wei, X Guo, H Yu, X Xie, Y Ye, Q Yuan
International Immunopharmacology 2021
MAIT cells, guardians of skin and mucosa?
I Nel, L Bertrand, A Toubal, A Lehuen
Mucosal Immunology 2021
BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program
TT Drashansky, EY Helm, N Curkovic, J Cooper, P Cheng, X Chen, N Gautam, L Meng, AJ Kwiatkowski, WO Collins, BG Keselowsky, D SantAngelo, Z Huo, W Zhang, L Zhou, D Avram
iScience 2021
Immune Equilibrium Depends on the Interaction Between Recognition and Presentation Landscapes
D Shevyrev, V Tereshchenko, V Kozlov
Frontiers in immunology 2021
Incorporating mucosal-associated invariant T cells into the pathogenesis of chronic liver disease
AJ Czaja
World journal of gastroenterology : WJG 2021
The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells
NJ Maurice, AK Taber, M Prlic
Journal of immunology (Baltimore, Md. : 1950) 2021
An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation
H Andrlová, MR van den Brink, KA Markey
Frontiers in Oncology 2021
A Multi-Omics Analysis of Mucosal-Associated-Invariant T Cells Reveals Key Drivers of Distinct Modes of Activation
K Schubert, I Karkossa, J Schor, B Engelmann, LM Steinheuer, T Bruns, U Rolle-Kampczyk, J Hackermüller, M von Bergen
Frontiers in immunology 2021
A multilayered immune system through the lens of unconventional T cells
T Mayassi, LB Barreiro, J Rossjohn, B Jabri
Nature 2021
Varicella Zoster Virus Impairs Expression of the Nonclassical Major Histocompatibility Complex Class I–Related Gene Protein (MR1)
Purohit SK, Samer C, McWilliam HE, Traves R, Steain M, McSharry BP, Kinchington PR, Tscharke DC, Villadangos JA, Rossjohn J, Abendroth A, Slobedman B
The Journal of Infectious Diseases 2021
Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity
C Boulouis, JB Gorin, J Dias, P Bergman, E Leeansyah, JK Sandberg
Journal of immunology (Baltimore, Md. : 1950) 2020
Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans
GM Swarbrick, A Gela, ME Cansler, MD Null, RB Duncan, E Nemes, M Shey, M Nsereko, H Mayanja-Kizza, S Kiguli, J Koh, WA Hanekom, M Hatherill, C Lancioni, DM Lewinsohn, TJ Scriba, DA Lewinsohn
Frontiers in immunology 2020
MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors
A Amini, D Pang, CP Hackstein, P Klenerman
Frontiers in immunology 2020
Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection
X Tang, S Zhang, Q Peng, L Ling, H Shi, Y Liu, L Cheng, L Xu, L Cheng, LA Chakrabarti, Z Chen, H Wang, Z Zhang
Science Advances 2020
MR1-Restricted T Cells Are Unprecedented Cancer Fighters
A Vacchini, A Chancellor, J Spagnuolo, L Mori, GD Libero
Frontiers in immunology 2020
Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries
AJ Corbett, W Awad, H Wang, Z Chen
Frontiers in immunology 2020
Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring “Universal” Donor T Cells
C Perez, I Gruber, C Arber
Frontiers in immunology 2020
Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis
MP Manna, V Orlando, B Tamburini, GD Badami, F Dieli, N Caccamo
Frontiers in immunology 2020
T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of “Innateness”
CA James, C Seshadri
Frontiers in immunology 2020
The Immune Modulating Properties of Mucosal-Associated Invariant T Cells
M Ioannidis, V Cerundolo, M Salio
Frontiers in immunology 2020
OMIP ‐070: NKp46 ‐Based 27‐Color Phenotyping to Define Natural Killer Cells Isolated From Human Tumor Tissues
M Frutoso, F Mair, M Prlic
Cytometry Part A 2020
Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells
JD Berkson, CK Slichter, HA DeBerg, MA Delaney, AS Woodward-Davis, NJ Maurice, Y Lwo, A Ko, J Hsu, YW Chiu, PS Linsley, D Dixon, M Prlic
ImmunoHorizons 2020
MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto
E Leeansyah, YY Hey, WR Sia, JH Ng, MY Gulam, C Boulouis, F Zhu, M Ahn, JY Mak, DP Fairlie, AL Kwa, JK Sandberg, LF Wang
iScience 2020
MAIT Cell Activation and Functions
TS Hinks, XW Zhang
Frontiers in immunology 2020
Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling
S Cole, J Murray, C Simpson, R Okoye, K Tyson, M Griffiths, D Baeten, S Shaw, A Maroof
Frontiers in immunology 2020
MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands
M Pavlovic, C Gross, C Chili, T Secher, E Treiner
Frontiers in immunology 2020
A Targeted Multi-omic Analysis Approach Measures Protein Expression and Low-Abundance Transcripts on the Single-Cell Level
F Mair, JR Erickson, V Voillet, Y Simoni, T Bi, AJ Tyznik, J Martin, R Gottardo, EW Newell, M Prlic
Cell Reports 2020
Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
KG Lal, D Kim, MC Costanzo, M Creegan, E Leeansyah, J Dias, D Paquin-Proulx, LA Eller, A Schuetz, Y Phuang-ngern, SJ Krebs, BM Slike, H Kibuuka, L Maganga, S Nitayaphan, J Kosgei, C Sacdalan, J Ananworanich, DL Bolton, NL Michael, BL Shacklett, ML Robb, MA Eller, JK Sandberg
Nature Communications 2020
The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin
Nature Immunology 2019
CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells
NJ Maurice, MJ McElrath, E Andersen-Nissen, N Frahm, M Prlic
Nature Communications 2019
Tissue-resident lymphocytes: from adaptive to innate immunity
H Sun, C Sun, W Xiao, R Sun
Cellular and Molecular Immunology 2019
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome
J Emgård, H Bergsten, JK McCormick, I Barrantes, S Skrede, JK Sandberg, A Norrby-Teglund
Proceedings of the National Academy of Sciences 2019
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
T Leng, HD Akther, CP Hackstein, K Powell, T King, M Friedrich, Z Christoforidou, S McCuaig, M Neyazi, CV Arancibia-Cárcamo, J Hagel, F Powrie, RS Peres, V Millar, D Ebner, R Lamichhane, J Ussher, TS Hinks, E Marchi, C Willberg, P Klenerman
Cell Reports 2019
Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis:
W Li, EL Lin, S Liangpunsakul, J Lan, S Chalasani, S Rane, P Puri, PS Kamath, AJ Sanyal, VH Shah, S Radaeva, DW Crabb, N Chalasani, Q Yu
Clinical and Translational Gastroenterology 2019
MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria
S Suliman, M Murphy, M Musvosvi, A Gela, EW Meermeier, H Geldenhuys, C Hopley, A Toefy, N Bilek, A Veldsman, WA Hanekom, JL Johnson, WH Boom, G Obermoser, H Huang, M Hatherill, DM Lewinsohn, E Nemes, TJ Scriba
Journal of immunology (Baltimore, Md. : 1950) 2019
Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules.
Sundström P, Szeponik L, Ahlmanner F, Sundquist M, Wong JSB, Lindskog EB, Gustafsson B, Quiding-Järbrink M
Oncotarget 2019
Human MAIT cells exit peripheral tissues and re-circulate via lymph in steady state conditions
Valentin Voillet, Marcus Buggert, Chloe Slichter, Julia Berkson, Florian Mair, Mary Addison, Yoav Dori, Gregory Nadolski, Maxim Itkin, Raphael Gottardo, Michael Betts, Martin Prlic
JCI Insight 2018
Ontogeny of human mucosal-associated invariant T cells and related T cell subsets
GB Youssef, M Tourret, M Salou, L Ghazarian, V Houdouin, S Mondot, Y Mburu, M Lambert, S Azarnoush, JS Diana, AL Virlouvet, M Peuchmaur, T Schmitz, JH Dalle, O Lantz, V Biran, S Caillat-Zucman
Journal of Experimental Medicine 2018
IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis
SK Whiteside, JP Snook, Y Ma, FL Sonderegger, C Fisher, C Petersen, JF Zachary, JL Round, MA Williams, JJ Weis
Journal of immunology (Baltimore, Md. : 1950) 2018
Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells
LC Garner, P Klenerman, NM Provine
Frontiers in immunology 2018
Mucosal-Associated Invariant T Cells in Autoimmune Diseases
A Chiba, G Murayama, S Miyake
Frontiers in immunology 2018
The CD4 − CD8 − MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8 + MAIT cell pool
J Dias, C Boulouis, JB Gorin, RH van den Biggelaar, KG Lal, A Gibbs, L Loh, MY Gulam, WR Sia, S Bari, WY Hwang, DF Nixon, S Nguyen, MR Betts, M Buggert, MA Eller, K Broliden, A Tjernlund, JK Sandberg, E Leeansyah
Proceedings of the National Academy of Sciences 2018
C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation
CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
eLife 2018
Contribution of APCs to mucosal-associated invariant T cell activation in infectious disease and cancer
MS Shey, A Balfour, KA Wilkinson, G Meintjes
Innate immunity 2018
MAIT cells and microbial immunity
EW Meermeier, MJ Harriff, E Karamooz, DM Lewinsohn
Immunology and Cell Biology 2018
Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells
J Dias, C Boulouis, MJ Sobkowiak, KG Lal, J Emgård, M Buggert, T Parrot, JB Gorin, E Leeansyah, JK Sandberg
Frontiers in immunology 2018
MAIT cells and viruses
JE Ussher, CB Willberg, P Klenerman
Immunology and Cell Biology 2018
Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells
NM Provine, B Binder, ME FitzPatrick, A Schuch, LC Garner, KD Williamson, B van Wilgenburg, R Thimme, P Klenerman, M Hofmann
Frontiers in immunology 2018
Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells
I Bernal, JD Hofmann, B Bulitta, F Klawonn, AM Michel, D Jahn, M Neumann-Schaal, D Bruder, L Jänsch
Frontiers in microbiology 2018
Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations
M Mpina, NJ Maurice, M Yajima, CK Slichter, HW Miller, M Dutta, MJ McElrath, KD Stuart, SC de Rosa, JP McNevin, PS Linsley, S Abdulla, M Tanner, SL Hoffman, R Gottardo, CA Daubenberger, M Prlic
Journal of immunology (Baltimore, Md. : 1950) 2017
Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child
L Ghazarian, S Caillat-Zucman, V Houdouin
Frontiers in immunology 2017
Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells
ES Lovelace, NJ Maurice, HW Miller, CK Slichter, R Harrington, A Magaret, M Prlic, SD Rosa, SJ Polyak, D Unutmaz
PloS one 2017
Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines
J Dias, E Leeansyah, JK Sandberg
Proceedings of the National Academy of Sciences 2017
The MAIT conundrum – how human MAIT cells distinguish bacterial colonization from infection in mucosal barrier tissues
JD Berkson, M Prlic
Immunology Letters 2017
Human mucosal-associated invariant T (MAIT) cells possess capacity for B-cell help
MS Bennett, S Trivedi, AS Iyer, JS Hale, DT Leung
Journal of leukocyte biology 2017
Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease
A Riva, V Patel, A Kurioka, HC Jeffery, G Wright, S Tarff, D Shawcross, JM Ryan, A Evans, S Azarian, JS Bajaj, A Fagan, V Patel, K Mehta, C Lopez, M Simonova, K Katzarov, T Hadzhiolova, S Pavlova, JA Wendon, YH Oo, P Klenerman, R Williams, S Chokshi
Gut 2017
Gene Expression Analysis of Neurons and Astrocytes Isolated by Laser Capture Microdissection from Frozen Human Brain Tissues
L Tagliafierro, K Bonawitz, OC Glenn, O Chiba-Falek
Frontiers in molecular neuroscience 2016
Targeting Innate-Like T Cells in Tuberculosis
S Huang
Frontiers in immunology 2016

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN 2379-3708

Sign up for email alerts

Posted by 5 X users
111 readers on Mendeley
See more details