Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 prevents myocyte injury and cardiac dysfunction in vivo in two murine models of ACM at baseline and in response to exercise. SB2-treated mice with desmosome mutations showed improvements in ventricular ectopy and myocardial fibrosis/inflammation as compared with vehicle-treated (Veh-treated) mice. GSK3β inhibition improved left ventricle function and survival in sedentary and exercised
Stephen P. Chelko, Angeliki Asimaki, Peter Andersen, Djahida Bedja, Nuria Amat-Alarcon, Deeptankar DeMazumder, Ravirasmi Jasti, Calum A. MacRae, Remo Leber, Andre G. Kleber, Jeffrey E. Saffitz, Daniel P. Judge
Title and authors | Publication | Year |
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Hot Phases Cardiomyopathy: Pathophysiology, Diagnostic Challenges, and Emerging Therapies
Bassetto G, Angriman F, Gava CP, Paldino A, Perotto M, Bordignon L, Gigli M, Ferro MD, Massa L, Altinier A, De Luca A, Sinagra G, Merlo M |
Current Cardiology Reports | 2025 |
Naxos Disease and Related Cardio-Cutaneous Syndromes
Protonotarios A, Asimaki A, Basso C, Xylouri Z, Monda E, Protonotarios I, Crisci G, Abrahms DJ, Anastasakis A, Antoniades L, Bakalakos A, Carbone A, S. Coonar A, Gimeno JR, Lazaros G, Lerakis S, Mestroni L, Papadopoulos G, Pecchia L, Prandi FR, Syrris P, Cadrin-Turigny J, Vasilakis A, Saffitz JE, Gaetano Thiene S, Elliott PM, Kaski JP, McKenna WJ, Bossone E, Limongelli G, Tsatsopoulou A |
JACC: Advances | 2025 |
Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy
Stephen Chelko, Vinay Penna, Morgan Engel, Maicon Landim-Vieira, Elisa N. Cannon, Kory Lavine, Jeffrey Saffitz |
Journal of Clinical Investigation | 2024 |
Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy
Fu M, Hua X, Shu S, Xu X, Zhang H, Peng Z, Mo H, Liu Y, Chen X, Yang Y, Zhang N, Wang X, Liu Z, Yue G, Hu S, Song J |
BMC Medicine | 2024 |
Targeting arrhythmogenic macrophages: Lessons learned from arrhythmogenic cardiomyopathy
Thassio Mesquita1 and Eugenio Cingolani1 |
Journal of Clinical Investigation | 2024 |
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy.
Panigrahy D, Kelly AG, Wang W, Yang J, Hwang SH, Gillespie M, Howard I, Bueno-Beti C, Asimaki A, Penna V, Lavine K, Edin ML, Zeldin DC, Hammock BD, Saffitz JE |
bioRxiv : the preprint server for biology | 2024 |
Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction
Fabritz L, Fortmueller L, Gehmlich K, Kant S, Kemper M, Kucerova D, Syeda F, Faber C, Leube RE, Kirchhof P, Krusche CA |
Biomedicines | 2024 |
Animal Models and Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy Associated with Pathogenic Variants in Intercalated Disc Genes
Vencato S, Romanato C, Rampazzo A, Calore M |
International journal of molecular sciences | 2024 |
High-Fat Diet Augments Myocardial Inflammation and Cardiac Dysfunction in Arrhythmogenic Cardiomyopathy
Centner AM, Shiel EA, Farra W, Cannon EN, Landim-Vieira M, Salazar G, Chelko SP |
Nutrients | 2024 |
Arrhythmogenic Cardiomyopathy: Current Updates and Future Challenges
Zathar Z, Shah N, Desai N, Patel PA |
2024 | |
In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal Models
Risato G, Brañas Casas R, Cason M, Bueno Marinas M, Pinci S, De Gaspari M, Visentin S, Rizzo S, Thiene G, Basso C, Pilichou K, Tiso N, Celeghin R |
Cells | 2024 |
Molecular Pathways and Animal Models of Arrhythmias.
Stevens TL, Coles S, Sturm AC, Hoover CA, Borzok MA, Mohler PJ, El Refaey M |
Advances in experimental medicine and biology | 2024 |
Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy
Penna VR, Amrute JM, Engel M, Shiel EA, Farra W, Cannon EN, Leu-Turner C, Ma P, Villanueva A, Shin H, Parvathaneni A, Jager J, Bueno-Beti C, Asimaki A, Lavine KJ, Saffitz JE, Chelko SP |
bioRxiv | 2024 |
Targeting Canonical Wnt-signaling Through GSK-3β in Arrhythmogenic Cardiomyopathy: Conservative or Progressive?
Low BS, Asimaki A |
Journal of Cardiovascular Translational Research | 2024 |
Genetic Inactivation of beta-Catenin Attenuates and Its Activation Aggravates Desmoplakin Cardiomyopathy
Melis Olcum, Siyang Fan, Leila Rouhi, Sirisha Cheedipudi, Benjamin Cathcart, Hyun-Hwan Jeong, Zhongming Zhao, Priyatansh Gurha, Ali Marian |
Cardiovascular Research | 2023 |
Myocardial Inflammation as a Manifestation of Genetic Cardiomyopathies: From Bedside to the Bench
Peretto G, Sommariva E, Di Resta C, Rabino M, Villatore A, Lazzeroni D, Sala S, Pompilio G, Cooper LT |
Biomolecules | 2023 |
Cheek-Pro-Heart: What Can the Buccal Mucosa Do for Arrhythmogenic Cardiomyopathy?
Bueno-Beti C, Asimaki A |
Biomedicines | 2023 |
Parsing cell death in arrhythmogenic cardiomyopathy: PANoptosis
MacRae CA |
2023 | |
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
Nielsen MS, van Opbergen CJ, van Veen TA, Delmar M |
Physiological reviews | 2023 |
GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy.
Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw RM |
Circulation research | 2023 |
Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis.
Marchal GA, Galjart N, Portero V, Remme CA |
Cardiovascular Research | 2023 |
Flight for fish in drug discovery: a review of zebrafish-based screening of molecules
Dash SN, Patnaik L |
Biology Letters | 2023 |
Arrhythmogenic Cardiomyopathy: from Preclinical Models to Genotype-phenotype Correlation and Pathophysiology.
Fan X, Yang G, Duru F, Grilli M, Akin I, Zhou X, Saguner AM, Ei-Battrawy I |
Stem Cell Reviews and Reports | 2023 |
Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy
Kim SL, Trembley MA, Lee KY, Choi S, MacQueen LA, Zimmerman JF, de Wit LH, Shani K, Henze DE, Drennan DJ, Saifee SA, Loh LJ, Liu X, Parker KK, Pu WT |
Stem Cell Reports | 2023 |
Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models
Chua CJ, Morrissette-McAlmon J, Tung L, Boheler KR |
Genes & development | 2023 |
The Many Faces of Arrhythmogenic Cardiomyopathy: An Overview
Tadros HJ, Miyake CY, Kearney DL, Kim JJ, Denfield SW |
The Application of Clinical Genetics | 2023 |
Management Strategies in Arrhythmogenic Cardiomyopathy across the Spectrum of Ventricular Involvement.
Maniar Y, Gilotra NA, Scheel PJ 3rd |
Biomedicines | 2023 |
The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities
Yu M, Qin K, Fan J, Zhao G, Zhao P, Zeng W, Chen C, Wang A, Wang Y, Zhong J, Zhu Y, Wagstaff W, Haydon RC, Luu HH, Ho S, Lee MJ, Strelzow J, Reid RR, He TC |
Genes & Diseases | 2023 |
Determinants of Electrical Propagation and Propagation Block in Arrhythmogenic Cardiomyopathy
Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber AG |
Journal of Molecular and Cellular Cardiology | 2023 |
Fibro-fatty remodelling in arrhythmogenic cardiomyopathy
A Kohela, E van Rooij |
Basic Research in Cardiology | 2022 |
Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics
Coscarella IL, Landim-Vieira M, Pinto JR, Chelko SP |
International journal of molecular sciences | 2022 |
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction.
Li G, Brumback BD, Huang L, Zhang DM, Yin T, Lipovsky CE, Hicks SC, Jimenez J, Boyle PM, Rentschler SL |
2022 | |
New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology
Forte M, Iacovone G, Sciarretta S |
JACC: Basic to Translational Science | 2022 |
Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade
Schinner C, Xu L, Franz H, Zimmermann A, Wanuske MT, Rathod M, Hanns P, Geier F, Pelczar P, Liang Y, Lorenz V, Stüdle C, Maly PI, Kauferstein S, Beckmann BM, Sheikh F, Kuster GM, Spindler V |
Circulation | 2022 |
Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy
Landim-Vieira M, Kahmini AR, Engel M, Cannon EN, Amat-Alarcon N, Judge DP, Pinto JR, Chelko SP |
International journal of molecular sciences | 2022 |
Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia
Yeruva S, Waschke J |
Journal of Anatomy | 2022 |
Elucidating arrhythmogenic right ventricular cardiomyopathy with stem cells
Laurita KR, Vasireddi SK, Mackall JA |
Birth Defects Research Part A Clinical and Molecular Teratology | 2022 |
The Challenges of Diagnosis and Treatment of Arrhythmogenic Cardiomyopathy: Are We there yet?
Spadotto A, Morabito D, Carecci A, Massaro G, Statuto G, Angeletti A, Graziosi M, Biagini E, Martignani C, Ziacchi M, Diemberger I, Biffi M |
2022 | |
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
E Sommariva, I Stadiotti, M Casella, V Catto, AD Russo, C Carbucicchio, L Arnaboldi, SD Metrio, G Milano, A Scopece, M Casaburo, D Andreini, S Mushtaq, E Conte, M Chiesa, W Birchmeier, E Cogliati, A Paolin, E König, V Meraviglia, MD Musso, C Volani, G Cattelan, W Rauhe, L Turnu, B Porro, M Pedrazzini, M Camera, A Corsini, C Tondo, A Rossini, G Pompilio |
EMBO Molecular Medicine | 2021 |
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy
SP Chelko, G Keceli, A Carpi, N Doti, J Agrimi, A Asimaki, CB Beti, M Miyamoto, N Amat-Codina, D Bedja, AC Wei, B Murray, C Tichnell, C Kwon, H Calkins, CA James, B ORourke, MK Halushka, E Melloni, JE Saffitz, DP Judge, M Ruvo, RN Kitsis, P Andersen, FD Lisa, N Paolocci |
Science Translational Medicine | 2021 |
Arrhythmogenic Cardiomyopathy—Current Treatment and Future Options
F Migliore, G Mattesi, A Zorzi, B Bauce, I Rigato, D Corrado, A Cipriani |
Journal of Clinical Medicine | 2021 |
Insights Into Genetics and Pathophysiology of Arrhythmogenic Cardiomyopathy
B Gerull, A Brodehl |
Current Heart Failure Reports | 2021 |
Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy
KE Ng, PJ Delaney, D Thenet, S Murtough, CM Webb, N Zaman, E Tsisanova, G Mastroianni, SL Walker, JD Westaby, DJ Pennington, R Pink, DP Kelsell, A Tinker |
Cell and Tissue Research | 2021 |
Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach
J Martínez-Solé, M Sabater-Molina, A Braza-Boïls, JJ Santos-Mateo, P Molina, L Martínez-Dolz, JR Gimeno, E Zorio |
Frontiers in Cardiovascular Medicine | 2021 |
Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy
SM Cheedipudi, S Fan, L Rouhi, AJ Marian |
2021 | |
Cardiomyopathies: An Overview
T Ciarambino, G Menna, G Sansone, M Giordano |
International journal of molecular sciences | 2021 |
Arrhythmogenic Cardiomyopathy Is a Multicellular Disease Affecting Cardiac and Bone Marrow Mesenchymal Stromal Cells
A Scalco, C Liboni, R Angioni, AD Bona, M Albiero, N Bertoldi, GP Fadini, G Thiene, SP Chelko, C Basso, A Viola, M Mongillo, T Zaglia |
Journal of Clinical Medicine | 2021 |
Hemi- and Homozygous Loss-of-Function Mutations in DSG2 (Desmoglein-2) Cause Recessive Arrhythmogenic Cardiomyopathy with an Early Onset
A Brodehl, A Meshkov, R Myasnikov, A Kiseleva, O Kulikova, B Klauke, E Sotnikova, C Stanasiuk, M Divashuk, GM Pohl, M Kudryavtseva, K Klingel, B Gerull, A Zharikova, J Gummert, S Koretskiy, S Schubert, E Mershina, A Gärtner, P Pilus, KT Laser, V Sinitsyn, S Boytsov, O Drapkina, H Milting |
International journal of molecular sciences | 2021 |
Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice
YN Lin, T Mesquita, L Sanchez, YH Chen, W Liu, C Li, R Rogers, Y Wang, X Li, D Wu, R Zhang, A Ibrahim, E Marbán, E Cingolani |
European Heart Journal | 2021 |
Targeting the Microtubule EB1-CLASP2 Complex Modulates Na V 1.5 at Intercalated Discs
GA Marchal, M Jouni, DY Chiang, M Pérez-Hernández, S Podliesna, N Yu, S Casini, F Potet, CC Veerman, M Klerk, EM Lodder, I Mengarelli, K Guan, CG Vanoye, E Rothenberg, F Charpentier, R Redon, AL George, AO Verkerk, CR Bezzina, CA MacRae, PW Burridge, M Delmar, N Galjart, V Portero, CA Remme |
Circulation research | 2021 |
Phenotypic recapitulation and correction of desmoglein-2-deficient cardiomyopathy using human-induced pluripotent stem cell-derived cardiomyocytes
M Shiba, S Higo, T Kondo, J Li, L Liu, Y Ikeda, Y Kohama, S Kameda, T Tabata, H Inoue, S Nakamura, M Takeda, E Ito, S Takashima, S Miyagawa, Y Sawa, S Hikoso, Y Sakata |
Human Molecular Genetics | 2021 |
Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC
RN Hawthorne, A Blazeski, J Lowenthal, S Kannan, R Teuben, D DiSilvestre, J Morrissette-McAlmon, JE Saffitz, KR Boheler, CA James, SP Chelko, G Tomaselli, L Tung |
Journal of Clinical Medicine | 2021 |
Pathogenesis of arrhythmogenic cardiomyopathy: role of inflammation
YN Lin, A Ibrahim, E Marbán, E Cingolani |
Basic Research in Cardiology | 2021 |
Histopathological Features and Protein Markers of Arrhythmogenic Cardiomyopathy
C Bueno-Beti, A Asimaki |
Frontiers in Cardiovascular Medicine | 2021 |
Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?
V Meraviglia, M Alcalde, O Campuzano, M Bellin |
Frontiers in Cardiovascular Medicine | 2021 |
Analysis of buccal mucosa as a prognostic tool in children with arrhythmogenic cardiomyopathy
C Beti, E Field, A Tsatsopoulou, G Perry, M Sheppard, E Behr, J Saffitz, J Kaski, A Asimaki |
Progress in Pediatric Cardiology | 2021 |
Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study
M Cerrone, G Marrón-Liñares, C van Opbergen, S Costa, M Bourfiss, M Pérez-Hernández, F Schlamp, F Sanchis-Gomar, K Malkani, K Drenkova, M Zhang, X Lin, A Heguy, B Velthuis, N Prakken, A LaGerche, H Calkins, C James, A Riele, M Delmar |
European Heart Journal | 2021 |
Genetic Animal Models for Arrhythmogenic Cardiomyopathy
B Gerull, A Brodehl |
Frontiers in physiology | 2020 |
Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design
TL Stevens, MJ Wallace, ME Refaey, JD Roberts, SN Koenig, PJ Mohler |
Journal of Cardiovascular Development and Disease | 2020 |
Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy
Y Ding, J Yang, P Chen, T Lu, K Jiao, DJ Tester, JR Giudicessi, K Jiang, MJ Ackerman, Y Li, DW Wang, HN Lee, DW Wang, X Xu |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2020 |
Mechanotransduction and Adrenergic Stimulation in Arrhythmogenic Cardiomyopathy: An Overview of in vitro and in vivo Models
G Beffagna, E Sommariva, M Bellin |
Frontiers in physiology | 2020 |
Arrhythmogenic cardiomyopathy: pathogenesis, pro-arrhythmic remodelling, and novel approaches for risk stratification and therapy
SM van der Voorn, AS te Riele, C Basso, H Calkins, CA Remme, TA van Veen |
Cardiovascular Research | 2020 |
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy
N Lubos, S van der Gaag, M Gerçek, S Kant, RE Leube, CA Krusche |
Basic Research in Cardiology | 2020 |
State of the Art Review on Genetics and Precision Medicine in Arrhythmogenic Cardiomyopathy
V Patel, B Asatryan, B Siripanthong, PB Munroe, A Tiku-Owens, LR Lopes, MY Khanji, A Protonotarios, P Santangeli, D Muser, FE Marchlinski, PA Brady, CA Chahal |
International journal of molecular sciences | 2020 |
Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies
E Monda, G Palmiero, M Rubino, F Verrillo, F Amodio, FD Fraia, R Pacileo, F Fimiani, A Esposito, A Cirillo, A Fusco, E Moscarella, G Frisso, MG Russo, G Pacileo, P Calabrò, O Scudiero, M Caiazza, G Limongelli |
International journal of molecular sciences | 2020 |
Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
A Protonotarios, PM Elliott |
European Cardiology Review | 2020 |
Psychosocial Stress Hastens Disease Progression and Sudden Death in Mice with Arrhythmogenic Cardiomyopathy
J Agrimi, A Scalco, J Agafonova, L Williams, N Pansari, G Keceli, S Jun, N Wang, F Mastorci, C Tichnell, B Murray, CA James, H Calkins, T Zaglia, N Paolocci, SP Chelko |
Journal of Clinical Medicine | 2020 |
Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation
Ronald Ng, Heather R Manring, Nikolaos Papoutsidakis, Taylor Albertelli, Nicole Tsai, Claudia J See, Xia Li, Jinkyu Park, Tyler L Stevens, Prameela Jyothi Bobbili, Muhammad Riaz, Yongming Ren, Christopher E Stoddard, Paul ML Janssen, T Jared Bunch, Stephen P Hall, Ying-Chun Lo, Daniel Jacoby, Yibing Qyang, Nathan Wright, Maegen A Ackermann, Stuart G Campbell |
JCI Insight | 2019 |
Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy
Jason D Roberts, Nathaniel P Murphy, Robert M. Hamilton, Ellen R Lubbers, Cynthia A. James, Crystal F. Kline, Michael H. Gollob, Andrew Krahn, Amy C Sturm, Hassan Musa, Mona El Refaey, Sara N Koenig, Meriam Åström Aneq, Edgar T Hoorntje, Sharon Graw, Shabana Aafaqi, Robert W Davies, Meena Fatah, Muhammad Arshad Rafiq, David A. Chiasson, Tamara T. Koopmann, Matthew R.G. Taylor, Samantha Simmons, Mei Han, Chantal J.M. van Opbergen, Loren Wold, Gianfranco Sinagra, Kirti Mittal, Crystal Tichnell, Brittney Murray, Alberto Codima, Babak Nazer, Duy T. Nguyen, Frank Marcus, Nara Sobreira, Elisabeth M. Lodder, Maarten van den Berg, Danna A Spears, John F Robinson, Philip C. Ursell, Anna Green, Allan C Skanes, Anthony S Tang, Martin Gardner, Robert A. Hegele, Toon A. B. van Veen, Arthur A.M. Wilde, Jeff Healey, Paul M.L. Janssen, Luisa Mestroni, J. Peter van Tintelen, Hugh Calkins, Daniel P. Judge, Thomas J Hund, Melvin Scheinman, Peter J. Mohler |
Journal of Clinical Investigation | 2019 |
Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β
L Padrón-Barthe, M Villalba-Orero, JM Gómez-Salinero, F Domínguez, M Román, J Larrasa-Alonso, P Ortiz-Sánchez, F Martínez, M López-Olañeta, E Bonzón-Kulichenko, J Vázquez, C Martí-Gómez, DJ Santiago, B Prados, G Giovinazzo, MV Gómez-Gaviro, S Priori, P Garcia-Pavia, E Lara-Pezzi |
Circulation | 2019 |
Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways
B Stump, S Shrestha, AM Lamattina, PH Louis, W Cho, MA Perrella, X Ai, IO Rosas, FF Wagner, C Priolo, J Astin, S El-Chemaly, M Ushio-Fukai |
PloS one | 2019 |
Mitochondrial Dysfunction as Substrate for Arrhythmogenic Cardiomyopathy: A Search for New Disease Mechanisms
CJ van Opbergen, L den Braven, M Delmar, TA van Veen |
Frontiers in physiology | 2019 |
Molecular mechanisms of arrhythmogenic cardiomyopathy
KM Austin, MA Trembley, SF Chandler, SP Sanders, JE Saffitz, DJ Abrams, WT Pu |
Nature Reviews Cardiology | 2019 |
Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report: Research goals in arrhythmogenic cardiomyopathy
PM Elliott, A Anastasakis, A Asimaki, C Basso, B Bauce, MA Brooke, H Calkins, D Corrado, F Duru, KJ Green, DP Judge, D Kelsell, PD Lambiase, WJ McKenna, K Pilichou, A Protonotarios, JE Saffitz, P Syrris, H Tandri, AT Riele, G Thiene, A Tsatsopoulou, JP van Tintelen |
European Journal of Heart Failure | 2019 |
Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
SP Chelko, A Asimaki, J Lowenthal, C Bueno-Beti, D Bedja, A Scalco, N Amat-Alarcon, P Andersen, DP Judge, L Tung, JE Saffitz |
Circulation | 2019 |
Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling
B Martin, B Gabris, AF Barakat, BL Henry, M Giannini, RP Reddy, X Wang, G Romero, G Salama |
Scientific Reports | 2019 |
Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles
G Li, A Khandekar, T Yin, SC Hicks, Q Guo, K Takahashi, CE Lipovsky, BD Brumback, PK Rao, CJ Weinheimer, SL Rentschler |
Journal of Molecular and Cellular Cardiology | 2018 |
Genetics of and pathogenic mechanisms in arrhythmogenic right ventricular cardiomyopathy
AK Vimalanathan, E Ehler, K Gehmlich |
Biophysical Reviews | 2018 |
Diagnostic and therapeutic strategies for arrhythmogenic right ventricular dysplasia/cardiomyopathy patient
W Wang, CA James, H Calkins |
Europace | 2018 |
Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell–Cell Adhesion Structures
RL Begay, SL Graw, G Sinagra, A Asimaki, TJ Rowland, DB Slavov, K Gowan, KL Jones, F Brun, M Merlo, D Miani, M Sweet, K Devaraj, EP Wartchow, M Gigli, I Puggia, EE Salcedo, DM Garrity, AV Ambardekar, P Buttrick, TB Reece, MR Bristow, JE Saffitz, L Mestroni, MR Taylor |
JACC: Clinical Electrophysiology | 2018 |
No major role for rare plectin variants in arrhythmogenic right ventricular cardiomyopathy
ET Hoorntje, A Posafalvi, P Syrris, KJ van der Velde, MC Bolling, A Protonotarios, LG Boven, N Amat-Codina, JA Groeneweg, AA Wilde, N Sobreira, H Calkins, RN Hauer, MF Jonkman, WJ McKenna, PM Elliott, RJ Sinke, MP van den Berg, SP Chelko, CA James, JP van Tintelen, DP Judge, JD Jongbloed, T Ai |
PloS one | 2018 |
Impact of Exercise Restriction on Arrhythmic Risk Among Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
W Wang, G Orgeron, C Tichnell, B Murray, J Crosson, O Monfredi, J CadrinTourigny, H Tandri, H Calkins, CA James |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
Potential new mechanisms of pro-arrhythmia in arrhythmogenic cardiomyopathy: focus on calcium sensitive pathways
CJ van Opbergen, M Delmar, TA van Veen |
Netherlands Heart Journal | 2017 |
WNT Signaling in Cardiac and Vascular Disease
S Foulquier, EP Daskalopoulos, G Lluri, KC Hermans, A Deb, WM Blankesteijn, MC Michel |
Pharmacological reviews | 2017 |
Molecular Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy
JE Saffitz |
Cardiovascular Pathology | 2017 |
Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies
KO Brandão, VA Tabel, DE Atsma, CL Mummery, RP Davis |
Disease models & mechanisms | 2017 |
Wnt/β-catenin pathway in arrhythmogenic cardiomyopathy
A Lorenzon, M Calore, G Poloni, LJ de Windt, P Braghetta, A Rampazzo |
Oncotarget | 2017 |
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy
GS Cho, DI Lee, E Tampakakis, S Murphy, P Andersen, H Uosaki, S Chelko, K Chakir, I Hong, K Seo, HS Chen, X Chen, C Basso, SR Houser, GF Tomaselli, B ORourke, DP Judge, DA Kass, C Kwon |
Cell Reports | 2017 |
Using Zebrafish for High-Throughput Screening of Novel Cardiovascular Drugs
A Kithcart, CA MacRae |
JACC: Basic to Translational Science | 2017 |
Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy
H Calkins, D Corrado, F Marcus |
Circulation | 2017 |
Genetics and Genomics of Single-Gene Cardiovascular Diseases
AJ Marian, E Rooij, R Roberts |
Journal of the American College of Cardiology | 2016 |