ResearchIn-Press PreviewAIDS/HIVImmunologyInfectious disease
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10.1172/jci.insight.208488
SIV infection disrupts the spatial cellular and communication networks of pulmonary granulomas during SIV/MTB co-infection
Jessica M. Medrano,1 Persis Sunny,1 Collin R. Diedrich,1 Pauline Maiello,2 Christopher Kline,3 Tara Rutledge,1 Edwin Klein,4 Joshua T. Mattila,2 Jishnu Das,5 Zandrea Ambrose,2 and Philana Ling Lin1
1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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1Department of Pediatrics, University of Pittsburgh Medical Center’s Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
2Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
4Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, United States of America
5Center for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
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Lin, P.
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Published September 24, 2026 - More info
Copyright © 2026, Medrano et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
