Research LetterIn-Press PreviewImmunologyInflammation
Open Access | 
10.1172/jci.insight.198630
Enhancing IgG fragment crystallisable sialylation improves the therapeutic activity of IL23 cytokine blockade
Sebastian Kämpf,1 Marjan Hematianlarki,1 Leon Altmann,1 Jessica M. Bright,2 Alyssa M. A. Toda,2 Zohreh Mirzapoor,1 Valentin Zollner,1 Anja Werner,1 Johanna Bulang,1 Barbara Radovani,1 Miriam Wöhner,1 William Avery,2 Mark J. Karbarz,2 Pamela B. Conley,2 Greg P. Coffey,2 and Falk Nimmerjahn1
1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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1Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen, Nürnberg, Germany
2Nuvig Therapeutics, Inc., Palo Alto, United States of America
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Published February 19, 2026 - More info
Copyright © 2026, Kämpf et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
