Research LetterIn-Press PreviewCardiologyCell biology
Open Access | 
10.1172/jci.insight.195410
A single dose of intravenous iron induces cardiac ferroptosis in murine cardiometabolic heart failure
Caitlin M. Pavelec,1 Leigh A. Bradley,1 Priyanka Rawat,2 Luke S. Dunaway,3 Maya Bolger-Chen,1 Bethany A. Gholson,1 Jonathan R. Lindner,1 Brant E. Isakson,4 Norbert Leitinger,4 and Matthew J. Wolf1
1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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1Department of Medicine, University of Virginia School of Medicine, Charlottesville, United States of America
2Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, United States of America
3Department of Biophysics and Molecular Biology, University of Virginia School of Medicine, Charlottesville, United States of America
4Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, United States of America
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Published February 26, 2026 - More info
Copyright © 2026, Pavelec et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
