Research LetterIn-Press PreviewGastroenterologyOncology
Open Access | 
10.1172/jci.insight.195194
Epigenomic profiling links IGF2 oveexpression to anthracycline resistance in colorectal cancer organoids
Tara L Hogenson,1 William Phillips,1 Merih D Toruner,1 Zachry S. Poshusta,2 Luciana Almada,1 Hao Xie,3 Ryan M. Carr,3 Jenny J. Li,3 David L. Marks,1 Renzo Vera,1 Erik Jessen,4 Michael Barrett,5 Joleen Hubbard,3 Travis E. Grotz,6 and Martin E. Fernandez-Zapico1
1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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1Division of Oncology Research, Mayo Clinic, Rochester, United States of America
2Division of Oncology Research, Mayo Cinic, Rochester, United States of America
3Division of Medical Oncology, Mayo Clinic, Rochester, United States of America
4Division of Computational Biology, Mayo Clinic, Rochester, United States of America
5Division of Hematology/Oncology, Mayo Clinic, Phoenix, United States of America
6Department of Surgery, Mayo Clinic, Rochester, United States of America
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Published July 20, 2026 - More info
Copyright © 2026, Hogenson et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
