ResearchIn-Press PreviewImmunologyInflammation
Open Access | 
10.1172/jci.insight.192830
Systemic reprogramming of monocytes in Crohn’s disease promotes their intestinal inflammatory function
Eve Hornsby,1 Radha Gadhok,1 Inva Hoti,1 Eva Wozniak,2 James R. Boot,2 Emma Connick,2 Paul A Stevens,2 Holly Creed,1 Amy Lewis,3 Andrew Silver,3 James O Lindsay,1 and Andrew J. Stagg1
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
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1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
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1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
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1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
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1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Boot, J. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Connick, E. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Stevens, P. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Creed, H. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Lewis, A. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Silver, A. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Lindsay, J. in: PubMed | Google Scholar
1Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom
2Genome Centre, Queen Mary University of London, London, United Kingdom
3Centre for Genomics and Child Health, Queen Mary University of London, London, United Kingdom
Find articles by Stagg, A. in: PubMed | Google Scholar
Published August 11, 2026 - More info
Copyright © 2026, Hornsby et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
