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Intestinal mucosal mitochondrial oxidative phosphorylation worsens with cirrhosis progression and is ameliorated with fecal microbiota transplantation
Jing Zeng, Derrick Zhao, Grayson Way, Andrew Fagan, Michael Fuchs, Puneet Puri, Brian C. Davis, Xuan Wang, Emily C. Gurley, Phillip B. Hylemon, Jian-Gao Fan, Masoumeh Sikaroodi, Patrick M. Gillevet, Huiping Zhou, Jasmohan S. Bajaj
Jing Zeng, Derrick Zhao, Grayson Way, Andrew Fagan, Michael Fuchs, Puneet Puri, Brian C. Davis, Xuan Wang, Emily C. Gurley, Phillip B. Hylemon, Jian-Gao Fan, Masoumeh Sikaroodi, Patrick M. Gillevet, Huiping Zhou, Jasmohan S. Bajaj
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Research Letter Hepatology Microbiology

Intestinal mucosal mitochondrial oxidative phosphorylation worsens with cirrhosis progression and is ameliorated with fecal microbiota transplantation

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Abstract

Authors

Jing Zeng, Derrick Zhao, Grayson Way, Andrew Fagan, Michael Fuchs, Puneet Puri, Brian C. Davis, Xuan Wang, Emily C. Gurley, Phillip B. Hylemon, Jian-Gao Fan, Masoumeh Sikaroodi, Patrick M. Gillevet, Huiping Zhou, Jasmohan S. Bajaj

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Figure 1

Intestinal mucosal changes in cirrhosis using cross-sectional and post-FMT approaches.

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Intestinal mucosal changes in cirrhosis using cross-sectional and post-F...
(A and B) Functional gene analysis in the DUOD: KEGG pathway analyses differentiate between healthy controls and patients with cirrhosis (A), as well as between compensated and decompensated stages of cirrhosis (B). (C and D) Gene expression profiles in cirrhosis: Hierarchical clustering heatmaps display changes in inflammation-related (C) and OXPHOS-related gene expression (D) in the DUOD and ASCEND colon of patients across different stages of cirrhosis compared with healthy controls, utilizing NanoString nCounter metabolic, inflammation, and fibrosis mRNA panels. (E and F) KEGG pathway analysis of DEGs in post-FMT DUOD versus pre-FMT (baseline). (E) DEGs suppressed after FMT. (F) DEGs activated after FMT.

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