Clinical MedicineIn-Press PreviewNeuroscience Open Access | 10.1172/jci.insight.175967
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Li, G. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Hu, Y. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Zhang, W. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Wang, J. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Sun, L. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Yu, J. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Manza, P. in: JCI | PubMed | Google Scholar |
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Volkow, N. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Ji, G. in: JCI | PubMed | Google Scholar
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Wang, G. in: JCI | PubMed | Google Scholar |
1Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, China
2School of Medicine, Northwest University, Xi'an, China
3Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi’an, China
4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, United States of America
5Department of Digestive Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China
6Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar
Published August 1, 2024 - More info
BACKGROUND. A polymorphism in the fat mass and obesity-associated gene (FTO) is linked to enhanced neural sensitivity to food-cues and attenuated ghrelin suppression. Risk allele carriers regain more weight than non-carriers after bariatric surgery. It remains unclear how FTO variation affects brain function and ghrelin following surgery.
METHODS. Resting-state functional magnetic resonance imaging (RS-fMRI) and cue-reactivity fMRI with high-/low-caloric food-cues were performed at pre-surgery and 1-, 6-, and 12-months post-surgery to examine brain function in 16 carriers with one copy of the rs9939609 A allele (AT) and 26 non-carriers (TT). Behavioral assessments up to five years post-surgery were also conducted.
RESULTS. AT relative to TT group had smaller BMI-loss at 12 to 60 months post-surgery and lower resting-state activity in posterior cingulate cortex following LSG (group-by-time interaction effects). Meanwhile, AT relative to TT group showed greater food-cue responses in dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC) and insula (group effects). There were negative associations of weight-loss with ghrelin and greater activation in DLPFC, DMPFC and insula in AT but not TT group.
CONCLUSION. These findings indicate that FTO variation is associated with the evolution of ghrelin signaling and brain function after bariatric surgery, which might hinder weight-loss.