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Characterization of comorbidity heterogeneity among 13,667 patients with hidradenitis suppurativa
Vivian J. Hua, … , Shufeng Li, Kavita Y. Sarin
Vivian J. Hua, … , Shufeng Li, Kavita Y. Sarin
Published September 21, 2021
Citation Information: JCI Insight. 2021;6(21):e151872. https://doi.org/10.1172/jci.insight.151872.
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Research Article Dermatology

Characterization of comorbidity heterogeneity among 13,667 patients with hidradenitis suppurativa

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Abstract

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder characterized by recurrent abscesses in the groin and flexural areas. HS is associated with a wide range of comorbidities that complicate the disease course. Although these comorbidities have been well described, it remains unclear how these comorbidities coassociate and whether comorbidity profiles affect disease trajectory. In addition, it is unknown how comorbidity associations are modulated by race and sex. In this comprehensive analysis of 77 million patients in a large US population–based cohort, we examined coassociation patterns among HS comorbidities and identified clinically relevant phenotypic subtypes within HS. We demonstrated that these subtypes not only differed among races, but also influenced clinical outcomes as measured by HS-related emergency department visits and cellulitis. Taken together, our findings provide key insights that elucidate the unique disease trajectories experienced by patients with HS and equip clinicians with a framework for risk stratification and improved targeted care in HS.

Authors

Vivian J. Hua, James M. Kilgour, Hyunje G. Cho, Shufeng Li, Kavita Y. Sarin

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Figure 1

Pairwise association of comorbidities.

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Pairwise association of comorbidities.
An 18 × 18 matrix of the Pearson ...
An 18 × 18 matrix of the Pearson r correlation of each disease phenotype pair among 13,667 patients. Only correlations significant at P less than 0.01 were plotted. Strong pairwise correlations are displayed between members of metabolic syndrome, CVD, tobacco/substance use, and mental health.

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