Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses — ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation —are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.
Jeffrey A. Haspel, Ron Anafi, Marishka K. Brown, Nicolas Cermakian, Christopher Depner, Paula Desplats, Andrew E. Gelman, Monika Haack, Sanja Jelic, Brian S. Kim, Aaron D. Laposky, Yvonne C. Lee, Emmanuel Mongodin, Aric A. Prather, Brian J. Prendergast, Colin Reardon, Albert C. Shaw, Shaon Sengupta, Éva Szentirmai, Mahesh Thakkar, Wendy E. Walker, Laura A. Solt
Title and authors | Publication | Year |
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ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients
Peter Cunningham, Gareth Kitchen, Callum Jackson, Stavros Pappachristos, Tom Springthorpe, David Vandellen, Julie Gibbs, Timothy Felton, Anthony Wilson, Jonathan Bannard-Smith, Martin Rutter, Thomas House, Paul Dark, Titus Augustine, Ozgur Akman, Andrew Hazel, John Blaikley |
Journal of Clinical Investigation | 2023 |
BIOLOGICAL RHYTHMS IN COVID-19 VACCINE EFFECTIVENESS, AN OBSERVATIONAL COHORT STUDY OF 1.5 MILLION PATIENTS
Guy Hazan, Or Duek, Hillel Alapi, Huram Mok, Alex Ganninger, Elaine Ostendorf, Carrie Gierasch, Gabriel Chodick, David Greenberg, Jeffrey Haspel |
Journal of Clinical Investigation | 2023 |
Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions
Huang H, Mehta A, Kalmanovich J, Anand A, Bejarano MC, Garg T, Khan N, Tonpouwo GK, Shkodina AD, Bardhan M |
Molecular Biology Reports | 2023 |
The Circadian Biology of Heart Failure
El Jamal N, Lordan R, Teegarden SL, Grosser T, FitzGerald G |
Circulation research | 2023 |
Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review.
Martin JA, Hart NH, Bradford N, Naumann F, Pinkham MB, Pinkham EP, Holland JJ |
Journal of Neuro-Oncology | 2023 |
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
Knauert MP, Ayas NT, Bosma KJ, Drouot X, Heavner MS, Owens RL, Watson PL, Wilcox ME, Anderson BJ, Cordoza ML, Devlin JW, Elliott R, Gehlbach BK, Girard TD, Kamdar BB, Korwin AS, Lusczek ER, Parthasarathy S, Spies C, Sunderram J, Telias I, Weinhouse GL, Zee PC |
American journal of respiratory and critical care medicine | 2023 |
The role of the circadian rhythms in critical illness with a focus on acute pancreatitis
Waddell H, Stevenson TJ, Mole DJ |
Heliyon | 2023 |
Circadian regulation of pulmonary disease: the importance of timing
Cunningham PS, Jackson C, Chakraborty A, Cain J, Durrington HJ, Blaikley JF |
Clinical science (London, England : 1979) | 2023 |
Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol
Yalçin M, Relógio A |
PloS one | 2023 |
Acute and repeated ozone exposures differentially affect circadian clock gene expression in mice
Sundar IK, Duraisamy SK, Choudhary I, Saini Y, Silveyra P |
2023 | |
The need to promote sleep health in public health agendas across the globe
Lim DC, Najafi A, Afifi L, Bassetti CL, Buysse DJ, Han F, Högl B, Melaku YA, Morin CM, Pack AI, Poyares D, Somers VK, Eastwood PR, Zee PC, Jackson CL |
The Lancet Public Health | 2023 |
Study on the correlation between lifestyle and negative conversion time in patients diagnosed with coronavirus disease (COVID-19): a retrospective cohort study.
Li N, Liu C, Qiu L, Shen C, Zhang F, Lu Z, Zhou M, Sheng D, Liu Z |
BMC Public Health | 2023 |
Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases
Castillejos-López M, Romero Y, Varela-Ordoñez A, Flores-Soto E, Romero-Martinez BS, Velázquez-Cruz R, Vázquez-Pérez JA, Ruiz V, Gomez-Verjan JC, Rivero-Segura NA, Camarena Á, Torres-Soria AK, Gonzalez-Avila G, Sommer B, Solís-Chagoyán H, Jaimez R, Torres-Espíndola LM, Aquino-Gálvez A |
Cells | 2023 |
Circadian lifestyle determinants of immune checkpoint inhibitor efficacy
Hughes BR, Shanaz S, Ismail-Sutton S, Wreglesworth NI, Subbe CP, Innominato PF |
Frontiers in Oncology | 2023 |
The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer
Balachandran DD, Bashoura L, Sheshadri A, Manzullo E, Faiz SA |
Frontiers in Oncology | 2023 |
Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents
Morales-Ghinaglia N, He F, Calhoun SL, Vgontzas AN, Liao J, Liao D, Bixler EO, Fernandez-Mendoza J |
Sleep | 2023 |