Go to The Journal of Clinical Investigation
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Transfers
  • Advertising
  • Job board
  • Contact
  • Physician-Scientist Development
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Immunology
    • Metabolism
    • Nephrology
    • Oncology
    • Pulmonology
    • All ...
  • Videos
  • Collections
    • In-Press Preview
    • Resource and Technical Advances
    • Clinical Research and Public Health
    • Research Letters
    • Editorials
    • Perspectives
    • Physician-Scientist Development
    • Reviews
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • In-Press Preview
  • Resource and Technical Advances
  • Clinical Research and Public Health
  • Research Letters
  • Editorials
  • Perspectives
  • Physician-Scientist Development
  • Reviews
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Transfers
  • Advertising
  • Job board
  • Contact

Citations to this article

Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary
Jeffrey A. Haspel, … , Wendy E. Walker, Laura A. Solt
Jeffrey A. Haspel, … , Wendy E. Walker, Laura A. Solt
Published January 16, 2020
Citation Information: JCI Insight. 2020;5(1):e131487. https://doi.org/10.1172/jci.insight.131487.
View: Text | PDF
Review

Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary

  • Text
  • PDF
Abstract

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses — ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation —are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.

Authors

Jeffrey A. Haspel, Ron Anafi, Marishka K. Brown, Nicolas Cermakian, Christopher Depner, Paula Desplats, Andrew E. Gelman, Monika Haack, Sanja Jelic, Brian S. Kim, Aaron D. Laposky, Yvonne C. Lee, Emmanuel Mongodin, Aric A. Prather, Brian J. Prendergast, Colin Reardon, Albert C. Shaw, Shaon Sengupta, Éva Szentirmai, Mahesh Thakkar, Wendy E. Walker, Laura A. Solt

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2009 Total
Citations: 13 23 16 24 22 15 1 114
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2023 (16)

Title and authors Publication Year
ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients
Peter Cunningham, Gareth Kitchen, Callum Jackson, Stavros Pappachristos, Tom Springthorpe, David Vandellen, Julie Gibbs, Timothy Felton, Anthony Wilson, Jonathan Bannard-Smith, Martin Rutter, Thomas House, Paul Dark, Titus Augustine, Ozgur Akman, Andrew Hazel, John Blaikley
Journal of Clinical Investigation 2023
BIOLOGICAL RHYTHMS IN COVID-19 VACCINE EFFECTIVENESS, AN OBSERVATIONAL COHORT STUDY OF 1.5 MILLION PATIENTS
Guy Hazan, Or Duek, Hillel Alapi, Huram Mok, Alex Ganninger, Elaine Ostendorf, Carrie Gierasch, Gabriel Chodick, David Greenberg, Jeffrey Haspel
Journal of Clinical Investigation 2023
Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions
Huang H, Mehta A, Kalmanovich J, Anand A, Bejarano MC, Garg T, Khan N, Tonpouwo GK, Shkodina AD, Bardhan M
Molecular Biology Reports 2023
The Circadian Biology of Heart Failure
El Jamal N, Lordan R, Teegarden SL, Grosser T, FitzGerald G
Circulation research 2023
Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review.
Martin JA, Hart NH, Bradford N, Naumann F, Pinkham MB, Pinkham EP, Holland JJ
Journal of Neuro-Oncology 2023
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
Knauert MP, Ayas NT, Bosma KJ, Drouot X, Heavner MS, Owens RL, Watson PL, Wilcox ME, Anderson BJ, Cordoza ML, Devlin JW, Elliott R, Gehlbach BK, Girard TD, Kamdar BB, Korwin AS, Lusczek ER, Parthasarathy S, Spies C, Sunderram J, Telias I, Weinhouse GL, Zee PC
American journal of respiratory and critical care medicine 2023
The role of the circadian rhythms in critical illness with a focus on acute pancreatitis
Waddell H, Stevenson TJ, Mole DJ
Heliyon 2023
Circadian regulation of pulmonary disease: the importance of timing
Cunningham PS, Jackson C, Chakraborty A, Cain J, Durrington HJ, Blaikley JF
Clinical science (London, England : 1979) 2023
Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol
Yalçin M, Relógio A
PloS one 2023
Acute and repeated ozone exposures differentially affect circadian clock gene expression in mice
Sundar IK, Duraisamy SK, Choudhary I, Saini Y, Silveyra P
2023
The need to promote sleep health in public health agendas across the globe
Lim DC, Najafi A, Afifi L, Bassetti CL, Buysse DJ, Han F, Högl B, Melaku YA, Morin CM, Pack AI, Poyares D, Somers VK, Eastwood PR, Zee PC, Jackson CL
The Lancet Public Health 2023
Study on the correlation between lifestyle and negative conversion time in patients diagnosed with coronavirus disease (COVID-19): a retrospective cohort study.
Li N, Liu C, Qiu L, Shen C, Zhang F, Lu Z, Zhou M, Sheng D, Liu Z
BMC Public Health 2023
Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases
Castillejos-López M, Romero Y, Varela-Ordoñez A, Flores-Soto E, Romero-Martinez BS, Velázquez-Cruz R, Vázquez-Pérez JA, Ruiz V, Gomez-Verjan JC, Rivero-Segura NA, Camarena Á, Torres-Soria AK, Gonzalez-Avila G, Sommer B, Solís-Chagoyán H, Jaimez R, Torres-Espíndola LM, Aquino-Gálvez A
Cells 2023
Circadian lifestyle determinants of immune checkpoint inhibitor efficacy
Hughes BR, Shanaz S, Ismail-Sutton S, Wreglesworth NI, Subbe CP, Innominato PF
Frontiers in Oncology 2023
The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer
Balachandran DD, Bashoura L, Sheshadri A, Manzullo E, Faiz SA
Frontiers in Oncology 2023
Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents
Morales-Ghinaglia N, He F, Calhoun SL, Vgontzas AN, Liao J, Liao D, Bixler EO, Fernandez-Mendoza J
Sleep 2023

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN 2379-3708

Sign up for email alerts