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Abstract
At the simplest level, obesity is the manifestation of an imbalance between caloric intake and expenditure; however, the pathophysiological mechanisms that govern the development of obesity and associated complications are enormously complex. Fibrosis within the adipose tissue compartment is one such factor that may influence the development of obesity and/or obesity-related comorbidities. Furthermore, the functional consequences of adipose tissue fibrosis are a matter of considerable debate, with evidence that fibrosis serves both adaptive and maladaptive roles. Tissue fibrosis itself is incompletely understood, and multiple cellular and molecular pathways are involved in the development, maintenance, and resolution of the fibrotic state. Within the context of obesity, fibrosis influences molecular and cellular events that relate to adipocytes, inflammatory cells, inflammatory mediators, and supporting adipose stromal tissue. In this Review, we explore what is known about the interplay between the development of adipose tissue fibrosis and obesity, with a view toward future investigative and therapeutic avenues.
Authors
Ritwik Datta, Michael J. Podolsky, Kamran Atabai
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Citations to this article (65)
| Title and authors | Publication | Year |
|---|---|---|
|
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Diolintzi A, Zhou Y, Fomina A, Sun Y, Husain S, Sidossis LS, Fried SK, Storch J |
Cells | 2025 |
|
Transient Dietary Intervention Induces Healthy Adipose Tissue Expansion and Metabolically Healthy Obesity in Mice
Wada E, Hosono H, Tanaka M, Miyakawa F, Ochi K, Kohda H, Tanno S, Shimano R, Ito A, Kitaura Y, Ichihara K, Matsumoto A, Ogi T, Satoh\u2010Asahara N, Murohara T, Suganami T |
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|
Pericytes as the Orchestrators of Vasculature and Adipogenesis
Picoli CD, Birbrair A, Li Z |
Genes & development | 2024 |
|
CD169(+) classical monocyte as an important participant in Graves' ophthalmopathy through CXCL12-CXCR4 axis.
Wang D, Ling J, Tan R, Wang H, Qu Y, Li X, Lin J, Zhang Q, Hu Q, Liu Z, Lu Z, Lin Y, Sun L, Wang D, Zhou M, Shi Z, Gao W, Ye H, Lin X |
iScience | 2024 |
|
Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue.
Robino JJ, Plekhanov AP, Zhu Q, Jensen MD, Scherer PE, Roberts CT, Varlamov O |
Obesity (Silver Spring, Md.) | 2024 |
|
Matrix stiffness regulates the triad communication of adipocytes/macrophages/endothelial cells through CXCL13.
Choisez A, Ishihara S, Ishii T, Xu Y, Firouzjah SD, Haga H, Nagatomi R, Kusuyama J |
Journal of lipid research | 2024 |
|
Single-Cell Analysis of Subcutaneous Fat Reveals Profibrotic Cells That Correlate With Visceral Adiposity in HIV
Bailin SS, Gabriel CL, Gangula RD, Hannah L, Nair S, Carr JJ, Terry JG, Silver HJ, Simmons JD, Mashayekhi M, Kalams SA, Mallal S, Kropski JA, Wanjalla CN, Koethe JR |
The Journal of Clinical Endocrinology and Metabolism | 2024 |
|
Identification of major hub genes involved in high-fat diet-induced obese visceral adipose tissue based on bioinformatics approach
Jiang Y, Zhang R, Guo JQ, Qian LL, Ji JJ, Wu Y, Ji ZJ, Yang ZW, Zhang Y, Chen X, Ma GS, Yao YY |
Adipocyte | 2023 |
|
Advanced Glycation End Products Effects on Adipocyte Niche Stiffness and Cell Signaling
Izgilov R, Naftaly A, Benayahu D |
International journal of molecular sciences | 2023 |
|
Association of Epicardial Adipose Tissue Adipocytes Hypertrophy with Biomarkers of Low-Grade Inflammation and Extracellular Matrix Remodeling in Patients with Coronary Artery Disease
Kologrivova IV, Naryzhnaya NV, Koshelskaya OA, Suslova TE, Kravchenko ES, Kharitonova OA, Evtushenko VV, Boshchenko AA |
Biomedicines | 2023 |
|
Adipose tissue aging is regulated by an altered immune system
Zhang YX, Ou MY, Yang ZH, Sun Y, Li QF, Zhou SB |
Frontiers in immunology | 2023 |
|
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity
He T, Wang S, Li S, Shen H, Hou L, Liu Y, Wei Y, Xie F, Zhang Z, Zhao Z, Mo C, Guo H, Huang Q, Zhang R, Shen D, Li B |
iScience | 2023 |
|
A novel 3D culture model for human primary mammary adipocytes to study their metabolic crosstalk with breast cancer in lean and obese conditions
Rebeaud M, Bouche C, Dauvillier S, Attané C, Arellano C, Vaysse C, Fallone F, Muller C |
Scientific Reports | 2023 |
|
The Role of IL-13 and IL-4 in Adipose Tissue Fibrosis
Arndt L, Lindhorst A, Neugebauer J, Hoffmann A, Hobusch C, Alexaki VI, Ghosh A, Blüher M, Wolfrum C, Glaß M, Gericke M |
International journal of molecular sciences | 2023 |
|
Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment
Willows JW, Robinson M, Alshahal Z, Morrison SK, Mishra G, Cyr H, Blaszkiewicz M, Gunsch G, DiPietro S, Paradie E, Tero B, Harrington A, Ryzhova L, Liaw L, Reifsnyder PC, Harrison DE, Townsend KL |
Aging Cell | 2023 |
|
Extracellular matrix remodelling in obesity and metabolic disorders
Musale V, Wasserman DH, Kang L |
2023 | |
|
Neonatal hyperoxia leads to white adipose tissue remodeling and susceptibility to hypercaloric diet.
Deprez A, Lukaszewski MA, De Sousa Do Outeiro C, Poletto Bonetto JH, He Y, Cloutier A, Ravizzoni Dartora D, Monique Nuyt A |
Physiological Reports | 2023 |
|
Differential effects of sugar and fat on adipose tissue inflammation
Avequin T, Lau KH, Waldhart AN, Guak H, Dykstra H, Krawczyk C, Wu N |
iScience | 2023 |
|
Hesperetin attenuates the expression of markers of adipose tissue fibrosis in pre-adipocytes.
Taheri A, Mobaser SE, Golpour P, Nourbakhsh M, Tavakoli-Yaraki M, Yarahmadi S, Nourbakhsh M |
2023 | |
|
A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic changes.
Qu Y, Wang Y, Wu T, Liu X, Wang H, Ma D |
Lipids in Health and Disease | 2023 |
|
Adipose tissue fibrosis: the unwanted houseguest invited by obesity
Gliniak CM, Pedersen L, Scherer PE |
The Journal of endocrinology | 2023 |
|
Obesity induces adipose fibrosis and collagen cross-linking through suppressing AMPK and enhancing lysyl oxidase expression
Xiangdong Liu, Liang Zhao, Yanting Chen, Yao Gao, Qiyu Tian, Jun Seok Son, Songah Chae, jeanene avila, Mei-Jun Zhu, Min Du |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2022 |
|
Healthy Subcutaneous and Omental Adipose Tissue Is Associated with High Expression of Extracellular Matrix Components
M Soták, MR Rajan, M Clark, C Biörserud, V Wallenius, CE Hagberg, E Börgeson |
International journal of molecular sciences | 2022 |
|
Aortic stiffness is lower when PVAT is included: a novel ex vivo mechanics study
T Tuttle, E Darios, S Watts, S Roccabianca |
American journal of physiology. Heart and circulatory physiology | 2022 |
|
Metabolic Messengers: fibroblast growth factor 1
E Gasser, G Sancar, M Downes, R Evans |
Nature metabolism | 2022 |
|
Adipose Tissue Extracellular Matrix Remodeling in Response to Dietary Patterns and Exercise: Molecular Landscape, Mechanistic Insights, and Therapeutic Approaches
de Sousa Neto IV, Durigan JL, da Silva AS, de Cássia Marqueti R |
Biology | 2022 |
|
Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology
Lecoutre S, Lambert M, Drygalski K, Dugail I, Maqdasy S, Hautefeuille M, Clément K |
Cells | 2022 |
|
Fibrosis in fat: From other diseases to Crohn's disease.
Xiong S, Tan J, Wang Y, He J, Hu F, Wu X, Liu Z, Lin S, Li X, Chen Z, Mao R |
Frontiers in immunology | 2022 |
|
Examination of the role of necroptotic damage-associated molecular patterns in tissue fibrosis.
Liu X, Lu F, Chen X |
Frontiers in immunology | 2022 |
|
Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice
Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S |
The Journal of biological chemistry | 2022 |
|
Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
Wang R, Sun Q, Wu X, Zhang Y, Xing X, Lin K, Feng Y, Wang M, Wang Y, Wang R |
Cells | 2022 |
|
Obese visceral fat tissue inflammation: from protective to detrimental?
Kolb H |
BMC Medicine | 2022 |
|
AMP‐activated protein kinase inhibition in fibro‐adipogenic progenitors impairs muscle regeneration and increases fibrosis
Liu X, Zhao L, Gao Y, Chen Y, Tian Q, Son JS, Chae SA, de Avila JM, Zhu M, Du M |
Journal of Cachexia, Sarcopenia and Muscle | 2022 |
|
NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
F Guo, M Seldin, M Péterfy, S Charugundla, Z Zhou, SD Lee, A Mouton, P Rajbhandari, W Zhang, M Pellegrini, P Tontonoz, AJ Lusis, DM Shih |
Scientific Reports | 2021 |
|
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
Y Majeed, N Halabi, AY Madani, R Engelke, AM Bhagwat, H Abdesselem, MV Agha, M Vakayil, R Courjaret, N Goswami, HB Hamidane, MA Elrayess, A Rafii, J Graumann, F Schmidt, NA Mazloum |
Scientific Reports | 2021 |
|
Age and Sex: Impact on adipose tissue metabolism and inflammation
M Varghese, J Song, K Singer |
Mechanisms of Ageing and Development | 2021 |
|
Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity
AD Ruggiero, CC Key, K Kavanagh |
Frontiers in Nutrition | 2021 |
|
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice
Q Chen, SM Lai, S Xu, Y Tan, K Leong, D Liu, JC Tan, RR Naik, AM Barron, SS Adav, J Chen, SZ Chong, LG Ng, C Ruedl |
EMBO reports | 2021 |
|
Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids
L Turner, S Santosa |
Advances in Nutrition | 2021 |
|
Early Childhood Fat Tissue Changes—Adipocyte Morphometry, Collagen Deposition, and Expression of CD163+ Cells in Subcutaneous and Visceral Adipose Tissue of Male Children
R Mujkić, DŠ Mujkić, I Ilić, E Rođak, A Šumanovac, A Grgić, D Divković, K Selthofer-Relatić |
International journal of environmental research and public health | 2021 |
|
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging
MD Luca, M Mandala, G Rose |
Mechanisms of Ageing and Development | 2021 |
|
Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion
H Sakashita, S Yamada, M Kinoshita, T Kajikawa, T Iwayama, S Murakami |
Scientific Reports | 2021 |
|
Necroptosis in Macrophage Foam Cells Promotes Fat Graft Fibrosis in Mice
X Chen, Z Deng, J Feng, Q Chang, F Lu, Y Yuan |
Frontiers in Cell and Developmental Biology | 2021 |
|
The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway
P Wang, J Feng, Z Zhang, Y Chen, Z Qin, X Dai, J Wei, B Hu, W Zhang, Y Sun, X Liu |
Acta Pharmacologica Sinica | 2021 |
|
Fight against fibrosis in adipose tissue remodeling
S Li, H Gao, Y Hasegawa, X Lu |
American journal of physiology. Endocrinology and metabolism | 2021 |
|
Hypoxia induces stress fiber formation in adipocytes in the early stage of obesity
G Anvari, E Bellas |
Scientific Reports | 2021 |
|
Tamarind Multifunctional Protein: Safety and Anti-Inflammatory Potential in Intestinal Mucosa and Adipose Tissue in a Preclinical Model of Diet-Induced Obesity
VC Lima, AB Luz, M do Socorro M. Amarante, MC Lima, FM Carvalho, JB Figueredo, PP Santos, CS Camillo, FV Ladd, BL Maciel, AF Uchôa, AH Morais |
Obesity facts | 2021 |
|
Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
MR Martínez-Cignoni, A González-Vicens, A Morán-Costoya, AM Proenza, M Gianotti, A Valle, I Lladó |
International journal of molecular sciences | 2021 |
|
Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance
T Geberhiwot, S Baig, C Obringer, D Girard, C Dawson, K Manolopoulos, N Messaddeq, PB Lassen, K Clement, JW Tomlinson, RP Steeds, H Dollfus, N Petrovsky, V Marion |
Diabetes | 2020 |
|
The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
M Clemente-Postigo, A Tinahones, RE Bekay, MM Malagón, FJ Tinahones |
Metabolites | 2020 |
|
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
MK DeBari, RD Abbott |
International journal of molecular sciences | 2020 |
|
Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity
M Ballester, R Quintanilla, FJ Ortega, JC Serrano, A Cassanyé, M Rodríguez-Palmero, JA Moreno-Muñoz, M Portero-Otin, J Tibau |
Scientific Reports | 2020 |
|
COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1
SN Dankel, E Grytten, JI Bjune, HJ Nielsen, A Dietrich, M Blüher, JV Sagen, G Mellgren |
Scientific Reports | 2020 |
|
Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity
M Varghese, C Griffin, K McKernan, L Eter, S Abrishami, K Singer |
Aging | 2020 |
|
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders
JD Gregorio, I Robuffo, S Spalletta, G Giambuzzi, VD Iuliis, E Toniato, S Martinotti, P Conti, V Flati |
Frontiers in Cell and Developmental Biology | 2020 |
|
Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling
HC Roh, M Kumari, S Taleb, D Tenen, C Jacobs, A Lyubetskaya, LT Tsai, ED Rosen |
Molecular Metabolism | 2020 |
|
Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity
X Unamuno, J Gómez-Ambrosi, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán |
Journal of Clinical Medicine | 2020 |
|
Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
MT Kaartinen, M Arora, S Heinonen, A Rissanen, J Kaprio, KH Pietiläinen |
International journal of molecular sciences | 2020 |
|
Adipose tissue depot‐specific intracellular and extracellular cues contributing to insulin resistance in obese individuals
R GuzmánRuiz, C TerceroAlcázar, Y RabanalRuiz, A DíazRuiz, RE Bekay, OA RangelZuñiga, MC NavarroRuiz, L Molero, A Membrives, JF RuizRabelo, A Pandit, J LópezMiranda, FJ Tinahones, MM Malagón |
The FASEB Journal | 2020 |
|
3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro
S Al-Ghadban, IA Pursell, ZT Diaz, KL Herbst, BA Bunnell |
International journal of molecular sciences | 2020 |
|
Deciphering the cellular interplays underlying the obesity-induced adipose tissue fibrosis
Genevieve Marcelin, Ana Leticia M. Silveira, Laís Bhering Martins, Adaliene Versiane Ferreira, Karine Clément |
Journal of Clinical Investigation | 2019 |
|
Genetic Deletion of Syndecan-4 Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet (Running Title: Sdc4 Deficiency Affects Metabolic Phenotypes)
MD Luca, D Vecchie, B Athmanathan, S Gopalkrishna, JA Valcin, TM Swain, R Sertie, K Wekesa, GC Rowe, SM Bailey, PR Nagareddy |
Nutrients | 2019 |
|
Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to Tumorigenesis
MD Cornò, A Baldassarre, E Calura, L Conti, P Martini, C Romualdi, R Varì, B Scazzocchio, M D'Archivio, A Masotti, S Gessani |
Frontiers in immunology | 2019 |
|
Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
D Estève, N Boulet, C Belles, A Zakaroff-Girard, P Decaunes, A Briot, Y Veeranagouda, M Didier, A Remaury, JC Guillemot, S Ledoux, C Dani, A Bouloumié, J Galitzky |
Nature Communications | 2019 |
|
Safe and effective subcutaneous adipolysis in minipigs by a collagenase derivative
F Chen, G Du, M Shih, H Yuan, P Bao, S Shi, Y Cang, Z Zhang, H Nadeem |
PloS one | 2019 |
