Video abstracts
In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.
In this episode Rachael Gordon and Haylee Cosgrove describe how NOX2 deficiency exacerbates lupus but the cell types and mechanisms by which NOX2 exerts protective effects remain unknown. They show that NOX2 regulates lupus by its function in macrophages/monocytes and B cells, where it modulates TLR7 signaling.
In this episode, Lilei Zhang and Weiyi Xu present data from their iPSC-CM study together with clinical observations that support the use of B-vitamins to mitigate cardiac crises in TANGO2-deficient disorder (TDD) patients, providing alternative treatment strategies during life-threatening events.
In this episode, Alessia Neri describes how their study examined 4CMenB vaccine in ART-treated PHIV and healthy controls showing good safety, B cell subsets alteration, and distinct immune signatures in PHIV children.
In this episode, Costanza Lo Cascio, Artak Tovmasyan, and Shwetal Mehta discuss the identification of a brain-penetrant HDAC inhibitor with radiosensitizing properties for the treatment of glioblastoma.
In this episode, Ryan Gimple and colleagues explain that glioblastoma stem cells depend on SNX10, an endosomal protein sorting factor, which maintains cancer cell proliferation and stemness through platelet-derived growth factor receptor signaling.
