Video abstracts
In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.
In this episode, Jakub Kubiak describes how spatial proteomic atlases of the human and mouse retina were used to reveal insights into the arrangement of major retinal cell populations and OLM structure.
In this episode, Kyle Medak describes how systemic semaglutide administration resulted in proteomic changes in the renal artery and kidney in pathways related to platelet aggregation, fibrin clot formation, lipid metabolism, and proapoptotic signaling that are abolished in mice lacking VSMC GLP-1R expression. Moreover, semaglutide directly induced vasorelaxation in preconstricted mesenteric arteries ex vivo. Together, these findings identify VSMCs as a key cellular target linking GLP-1R activation to BP regulation, renal electrolyte excretion, and proteomic changes in renal artery and kidney.
In this episode, Emmanuel Rapp and Jiayi Pang explain their findings that suggest that topical rosemary extract may represent an effective and accessible therapeutic approach to improve skin repair outcomes.
In this episode, David Ellison, Sebastian Bachman, and Jessica Bahena-Lopez describe how their results show that there are three cell types along the kidney thick ascending limb, enabling it to adjust solute absorption selectively to maintain homeostasis.
In this episode, Liza Makowski explains that bariatric surgery causes long term changes to our gut microbiome, which the study demonstrates could improve the body’s immune response to current breast cancer treatments.
