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Protection against preterm birth and fetal inflammatory injury
In this episode, Nardhy Gomez-Lopez explains that macrophages exert anti-inflammatory effects in late gestation, to maintain uterine quiescence and to protect against fetal inflammatory injury that compromises postnatal survival...
Published October 13, 2021
Video Abstracts
MLK3 mediation and the impact of PKG1α on cardiac function
In this episode, Robert Blanton explains how this paper identifies mixed lineage kinase 3 as a novel PKG1a substrate. MLK3 mediates PKGI therapeutic effects on LV function but regulates blood pressure independently of PKG1...
Published September 22, 2021
Video Abstracts
Antibodies to vaccine-preventable infections and CAR-T cell therapy
In this episode, Joshua Hill explains that they investigated antibodies to vaccine-preventable infections and other pathogen-specific antibodies in individuals with remission after CAR-T-cell therapy for B-lineage malignancies...
Published June 22, 2021
Video Abstracts
Regulation of human brown/beige adipocyte lipolysis and thermogenesis
In this episode, Cheryl Cero explains that β3-ARs in human brown/beige adipocytes are required to maintain multiple components of lipolytic and thermogenic cellular machinery and β3-AR agonists could be used to achieve metabolic benefit in humans...
Published June 18, 2021
Video Abstracts
Base editing in human primary muscle stem cells and mutation repair
In this episode, Helena Escobar and Simone Spuler explain that patient primary muscle stems cells gene repaired with greater than 90% efficiency by base editing maintain their regenerative properties...
Published May 28, 2021
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Peptide recognition by T and B cells in rheumatoid arthritis
In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis...
Published April 22, 2021
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Humanized mouse models of MC4R-linked obesity
In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity...
Published March 25, 2021
Video Abstracts
Aging and T cells during recovery from influenza pneumonia
The age-related pro-repair function of Treg cells following influenza infection is determined by cell-autonomous mechanisms...
Published March 23, 2021
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Protection against iatrogenically induced hearing loss
In this episode, Marisa Zallocchi explains how treatment with quinoxaline derivatives protects from aminoglycoside- and cisplatin-hearing loss by NF-kB inhibition...
Published March 11, 2021
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Epithelial IL-33 in chronic airway disease
In this episode, Jennifer Alexander-Brett and colleagues explain that epithelial IL-33 co-secretion with exosomes is blocked by inhibitors of the neutral...
Published February 26, 2021
Video Abstracts
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