Better identification of severe acute graft-versus-host disease (GvHD) may improve the outcome of this life-threatening complication of allogeneic hematopoietic stem cell transplantation. GvHD induces tissue damage and the release of damage-associated molecular pattern (DAMP) molecules. Here, we analyzed GvHD patients (
Antoine Seignez, Anne-Laure Joly, Killian Chaumonnot, Adonis Hazoumé, Michel Sanka, Guillaume Marcion, Christophe Boudesco, Arlette Hammann, Renaud Seigneuric, Gaetan Jégo, Patrick Ducoroy, Patrice Delarue, Patrick Senet, Cristina Castilla-Llorente, Eric Solary, Marie-Agnès Durey, Marie-Thérèse Rubio, Olivier Hermine, Evelyne Kohli, Carmen Garrido
Gp96 expression in acute GvHD patient sera.
Available sera from 39 patients were sampled 7 days before onset (D-7), the day of acute GvHD onset, and 7 days and 14 days after diagnosis (D+7 and D+14, respectively). Gp96 was quantified by ELISA. (