Genome-wide association studies of asthma have identified genetic variants in the
Erin D. Gordon, Joe Palandra, Agata Wesolowska-Andersen, Lando Ringel, Cydney L. Rios, Marrah E. Lachowicz-Scroggins, Louis Z. Sharp, Jamie L. Everman, Hannah J. MacLeod, Jae W. Lee, Robert J. Mason, Michael A. Matthay, Richard T. Sheldon, Michael C. Peters, Karl H. Nocka, John V. Fahy, Max A. Seibold
Title and authors | Publication | Year |
---|---|---|
IL1RL1 variant may affect the response to type 2 biologics in patients with severe asthma
Nishi K, Matsumoto H, Sunadome H, Nagasaki T, Oguma T, Tashima N, Hayashi Y, Terada S, Morita K, Yoshimura C, Nishizaka Y, Sano A, Iwanaga T, Sano H, Haraguchi R, Tohda Y, Kawaguchi T, Matsuda F, Hirai T |
ERJ Open Research | 2025 |
Sequencing and health data resource of children of African ancestry
Kottyan LC, Richards S, Tracy ME, Lawson LP, Cobb B, Esslinger S, Gerwe M, Morgan J, Chandel A, Travitz L, Huang Y, Black C, Sobowale A, Akintobi T, Mitchell M, Beck AF, Unaka N, Seid M, Fairbanks S, Adams M, Mersha T, Namjou B, Pauciulo MW, Strawn JR, Ammerman RT, Santel D, Pestian J, Glauser T, Prows CA, Martin LJ, Muglia L, Harley JB, Chepelev I, Kaufman KM |
medRxiv | 2025 |
Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease.
Jamali MC, Mohamed AH, Jamal A, Kamal MA, Al Abdulmonem W, Saeed BA, Mansuri N, Ahmad F, Mudhafar M, Shafie A, Hattiwale HM |
Journal of inflammation (London, England) | 2025 |
Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity
Donoghue LJ, Benner C, Chang D, Irudayanathan FJ, Pendergrass RK, Yaspan BL, Mahajan A, McCarthy MI |
Cell Genomics | 2025 |
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota
Röwekamp I, Maschirow L, Rabes A, Fiocca Vernengo F, Hamann L, Heinz GA, Mashreghi MF, Caesar S, Milek M, Fagundes Fonseca AC, Wienhold SM, Nouailles G, Yao L, Mousavi S, Bruder D, Boehme JD, Puzianowska-Kuznicka M, Beule D, Witzenrath M, Löhning M, Klose CS, Heimesaat MM, Diefenbach A, Opitz B |
Proceedings of the National Academy of Sciences | 2024 |
Mast Cells Control Lung Type 2 Inflammation via Prostaglandin E2-Driven Soluble ST2
Alhallak K, Nagai J, Zaleski K, Marshall S, Salloum T, Derakhshan T, Hayashi H, Feng C, Kratchmarov R, Lai J, Kuchibhotla V, Nishida A, Balestrieri B, Laidlaw T, Dwyer DF, Boyce JA |
Immunity | 2024 |
Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children.
Kelchtermans J, March ME, Hakonarson H, McGrath-Morrow SA |
Scientific reports | 2024 |
Interleukin-33–activated basophils promote asthma by regulating Th2 cell entry into lung tissue
Schuijs MJ, Brenis Gomez CM, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, Beyaert R, Voehringer D, Locksley RM, Hammad H, Lambrecht BN |
The Journal of Experimental Medicine | 2024 |
Exploring potential therapeutic targets for asthma: a proteome-wide Mendelian randomization analysis
Jiang Y, Wang Y, Guo J, Wang Z, Wang X, Yao X, Yang H, Zou Y |
Journal of Translational Medicine | 2024 |
Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation
Portelli MA, Ketelaar ME, Bates S, Csomor E, Shaw D, Emsley J, Brightling C, Hall I, Affleck K, Edwards M, Nawijn MC, Koppelman GH, Van Oosterhout AJ, Sayers I |
Clinical and Experimental Allergy | 2024 |
Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells
Ghosh A, Rogers Jr. KL, Gallant SC, Brocke SA, Speen AM, Kim YH, Gilmour MI, Randell SH, Jaspers I |
Toxicological Sciences | 2024 |
Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype
Rojo-Tolosa S, Sánchez-Martínez JA, Pineda-Lancheros LE, Gálvez-Navas JM, González-Gutiérrez MV, Jiménez-Gálvez G, Pérez-Ramírez C, Morales-García C, Jiménez-Morales A |
International journal of molecular sciences | 2023 |
Genetic Variants Associated with Bronchial Asthma Specific to the Population of the Russian Federation
Akhmerova YN, Shpakova TA, Grammatikati KS, Mitrofanov SI, Kazakova PG, Mkrtchian AA, Zemsky PU, Pilipenko MN, Feliz NV, Frolova LV, Frolovskaya AA, Yudin VS, Keskinov AA, Kraevoy SA, Yudin SM, Skvortsova VI |
Acta Naturae | 2023 |
Gene Signatures and Associated Transcription Factors of Allergic Rhinitis: KLF4 Expression Is Associated with Immune Response
Jeon Y, Kang TK, Lee WB, Jung SH, Kim YJ |
BioMed Research International | 2023 |
Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma
Murphy RC, Lai Y, Liu M, Al-Shaikhly T, Altman MC, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Gharib SA, Hallstrand TS |
American journal of respiratory and critical care medicine | 2023 |
Airway Transcriptome Networks Identify Susceptibility to Frequent Asthma Exacerbations in Children
Phelan KJ, Dill-McFarland KA, Kothari A, Segnitz RM, Burkle J, Grashel B, Jenkins S, Spagna D, Martin LJ, Haslam DB, Biagini JM, Kalra M, McCoy KS, Ross KR, Jackson DJ, Mersha T, Altman MC, Khurana Hershey GK |
Journal of Allergy and Clinical Immunology | 2023 |
IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels.
Faiz A, Mahbub RM, Boedijono FS, Tomassen MI, Kooistra W, Timens W, Nawijn M, Hansbro PM, Johansen MD, Pouwels SD, Heijink IH, Massip F, de Biase MS, Schwarz RF, Adcock IM, Chung KF, van der Does A, Hiemstra PS, Goulaouic H, Xing H, Abdulai R, de Rinaldis E, Cunoosamy D, Harel S, Lederer D, Nivens MC, Wark PA, Kerstjens HAM, Hylkema MN, Brandsma CA, van den Berge M |
American journal of respiratory and critical care medicine | 2023 |
The Role of Defective Epithelial Barriers in Allergic Lung Disease and Asthma Development
N Noureddine, M Chalubinski, P Wawrzyniak |
Journal of asthma and allergy | 2022 |
A role for IL-33-activated ILC2s in eosinophilic vasculitis
Maya Kotas, Jérémie Dion, Steven Van Dyken, Roberto R. Ricardo-Gonzalez, Claire J. Danel, Camille Taillé, Luc Mouthon, Richard M. Locksley, Benjamin Terrier |
JCI Insight | 2021 |
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness
K Han, K Singh, MJ Rodman, S Hassanzadeh, Y Baumer, RD Huffstutler, J Chen, J Candia, F Cheung, KE Stagliano, M Pirooznia, TM Powell-Wiley, MN Sack |
Nutrients | 2021 |
Association of IL33, IL1RL1, IL1RAP Polymorphisms and Asthma in Chinese Han Children
M Wu, X Zheng, J Huang, X Hu |
Frontiers in Cell and Developmental Biology | 2021 |
The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils
B Ditz, A Sarma, HA Kerstjens, JJ Liesker, E Bathoorn, JM Vonk, V Bernal, P Horvatovich, V Guryev, S Caldera, C Langelier, A Faiz, SA Christenson, M van den Berge |
ERJ Open Research | 2021 |
Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction
DT Dugger, DR Calabrese, Y Gao, F Deiter, T Tsao, J Maheshwari, SR Hays, L Leard, ME Kleinhenz, R Shah, J Golden, J Kukreja, ED Gordon, JP Singer, JR Greenland |
Frontiers in immunology | 2021 |
Transcriptomic Signature of Asthma–Chronic Obstructive Pulmonary Disease Overlap in Whole Blood
A Saferali, JH Yun, S Lee, RP Chase, RP Bowler, PJ Castaldi, CP Hersh |
American journal of respiratory cell and molecular biology | 2021 |
Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations
M Portelli, K Rakkar, S Hu, Y Guo, I Adcock |
2021 | |
Interleukin (IL)-33 Immunobiology in Asthma and Airway Inflammatory Diseases
Gaurav R, Poole JA |
Journal of Asthma | 2021 |
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and the airway epithelium in asthma
Michael A Portelli, F. Nicole Dijk, Maria E. Ketelaar, Nick Shrine, Jenny Hankinson, Sangita Bhaker, Neomi S. Grotenboer, Ma'en Obeidat, Amanda P Henry, Charlotte K. Billington, Dominick E. Shaw, Simon Johnson, Zara E.K. Pogson, Andrew W Fogarty, tricia M mckeever, David Nickle, Yohan Bossé, Maarten van den Berge, Alen Faiz, Sharon Brouwer, Judith M Vonk, Paul de Vos, Corry-Anke Brandsma, Cornelis J Vermeulen, Amisha Singapuri, Liam G Heaney, Adel H. Mansur, Rekha Chaudhuri, Neil C Thomson, John W. Holloway, Gabrielle A. Lockett, Peter Howarth, Rob Niven, Angela Simpson, John D. Blakey, Martin D Tobin, Dirkje S. Postma, Ian P. Hall, Louise V. Wain, Martijn C. Nawijn, Christopher Brightling, Gerard H. Koppelman, Ian Sayers |
JCI Insight | 2020 |
IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
R Dagher, AM Copenhaver, V Besnard, A Berlin, F Hamidi, M Maret, J Wang, X Qu, Y Shrestha, J Wu, G Gautier, R Raja, M Aubier, R Kolbeck, AA Humbles, M Pretolani |
Nature Communications | 2020 |
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
AD Bretherick, O Canela-Xandri, PK Joshi, DW Clark, K Rawlik, TS Boutin, Y Zeng, C Amador, P Navarro, I Rudan, AF Wright, H Campbell, V Vitart, C Hayward, JF Wilson, A Tenesa, CP Ponting, JK Baillie, C Haley, GD Smith |
PLoS genetics | 2020 |
Epithelial cell dysfunction, a major driver of asthma development
IH Heijink, VN Kuchibhotla, MP Roffel, T Maes, DA Knight, I Sayers, MC Nawijn |
Allergy | 2020 |
A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma
MC Peters, L Ringel, N Dyjack, R Herrin, PG Woodruff, C Rios, B OConnor, JV Fahy, MA Seibold |
American journal of respiratory and critical care medicine | 2019 |
IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids
FN Dijk, SJ Vijverberg, N HernandezPacheco, K Repnik, L Karimi, M Mitratza, N Farzan, MC Nawijn, EG Burchard, M Engelkes, KM Verhamme, U Potočnik, M PinoYanes, DS Postma, AH der Zee, GH Koppelman |
Allergy | 2019 |
Interleukin-13 Stimulation Reveals the Cellular and Functional Plasticity of the Airway Epithelium
MA Seibold |
Annals of the American Thoracic Society | 2018 |
Meta-analysis of airway epithelium gene expression in asthma
YH Tsai, JS Parker, IV Yang, SN Kelada |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2018 |
Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study
LP Hayden, MH Cho, BA Raby, TH Beaty, EK Silverman, CP Hersh |
Respiratory Research | 2018 |
Proteomic analysis of serum proteins from HIV/AIDS patients with Talaromyces marneffei infection by TMT labeling-based quantitative proteomics
Y Chen, A Huang, W Ao, Z Wang, J Yuan, Q Song, D Wei, H Ye |
Clinical Proteomics | 2018 |
Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome
A Wesolowska-Andersen, JL Everman, R Davidson, C Rios, R Herrin, C Eng, WJ Janssen, AH Liu, SS Oh, R Kumar, TE Fingerlin, J Rodriguez-Santana, EG Burchard, MA Seibold |
Genome biology | 2017 |