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Abstract
Early after HIV infection there is substantial depletion of CD4+ T cells in the gastrointestinal (GI) tract lamina propria (LP), with associated epithelial barrier damage, leading to microbial translocation and systemic inflammation and immune activation. In this study, we analyzed these early events in the GI tract in a cohort of Thai acute HIV-infected patients and determined the effect of early combination antiretroviral treatment (cART). HIV-uninfected and chronically and acutely HIV-infected patients at different Fiebig stages (I–V) underwent colonic biopsies and then received cART. Immunohistochemistry and quantitative image analysis were performed on cross-sectional and longitudinal colon biopsy specimens (day 0 to week 96) to measure GI tract damage (infiltration of polymorphonuclear cells), inflammation (Mx1, TNF-α), immune activation (Ki-67), and the CD4+ T cell population in the LP. The magnitude of GI tract damage, immune activation, and inflammation was significantly increased, with significantly depleted CD4+ T cells in the LP in all acutely infected groups prior to cART compared with HIV-uninfected control participants. While most patients treated during acute infection resolved GI tract inflammation and immune activation back to baseline levels after 24 weeks of cART, most acutely infected participants did not restore their CD4+ T cells after 96 weeks of cART.
Authors
Claire Deleage, Alexandra Schuetz, W. Gregory Alvord, Leslie Johnston, Xing-Pei Hao, David R. Morcock, Rungsun Rerknimitr, James L.K. Fletcher, Suwanna Puttamaswin, Nittaya Phanuphak, Robin Dewar, Joseph M. McCune, Irini Sereti, Merlin Robb, Jerome H. Kim, Timothy W. Schacker, Peter Hunt, Jeffrey D. Lifson, Jintanat Ananworanich, Jacob D. Estes, on behalf of the RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups
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Citations to this article (50)
| Title and authors | Publication | Year |
|---|---|---|
|
Acute HIV-1 Infection: Paradigm and Singularity
Chéret A |
Viruses | 2025 |
|
Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir
De Clercq J, De Scheerder MA, Mortier V, Verhofstede C, Vandecasteele SJ, Allard SD, Necsoi C, De Wit S, Gerlo S, Vandekerckhove L |
Frontiers in immunology | 2024 |
|
Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease
Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso M, Martin J, Hecht F, Pilcher C, Cohen SE, Buchbinder S, Havlir D, Gandhi M, Henrich TJ, Hatano H, Wang J, Deeks SG, Lee SA |
2024 | |
|
Nuclear Factor Kappa B p65: A Possible Biomarker for Persistent Inflammation in HIV-1 Infection?
Gnanaskandan S, Srikanth P |
Cureus | 2024 |
|
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease.
Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso MJ, Martin J, Hecht F, Pilcher C, Cohen SE, Buchbinder S, Havlir D, Gandhi M, Henrich TJ, Hatano H, Wang J, Deeks SG, Lee SA |
Nature communications | 2024 |
|
Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes
Pandit H, Valentin A, Angel M, Deleage C, Bergamaschi C, Bear J, Sowder R, Felber BK, Pavlakis GN |
iScience | 2023 |
|
Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys
Le Hingrat Q, Sette P, Xu C, Rahmberg AR, Tarnus L, Annapureddy H, Kleinman A, Brocca-Cofano E, Sivanandham R, Sivanandham S, He T, Capreri DJ, Ma D, Estes JD, Brenchley JM, Apetrei C, Pandrea I |
Nature Communications | 2023 |
|
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.
Jensen BO, Knops E, Cords L, Lübke N, Salgado M, Busman-Sahay K, Estes JD, Huyveneers LEP, Perdomo-Celis F, Wittner M, Gálvez C, Mummert C, Passaes C, Eberhard JM, Münk C, Hauber I, Hauber J, Heger E, De Clercq J, Vandekerckhove L, Bergmann S, Dunay GA, Klein F, Häussinger D, Fischer JC, Nachtkamp K, Timm J, Kaiser R, Harrer T, Luedde T, Nijhuis M, Sáez-Cirión A, Schulze Zur Wiesch J, Wensing AMJ, Martinez-Picado J, Kobbe G |
Nature Medicine | 2023 |
|
Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals
Guo X, Wang Z, Qu M, Guo Y, Yu M, Hong W, Zhang C, Fan X, Song J, Xu R, Zhang J, Huang H, Linghu E, Wang FS, Sun L, Jiao YM |
mSystems | 2023 |
|
Anti-HIV antibody development up to one year after antiretroviral therapy initiation in acute HIV infection
Julie L. Mitchell, Justin Pollara, Kenneth Dietze, R. Whitney Edwards, Junsuke Nohara, Kombo F. N'guessan, Michelle Zemil, Supranee Buranapraditkun, Hiroshi Takata, Yifan Li, Roshell Muir, Eugene Kroon, Suteeraporn Pinyakorn, Shalini Jha, Sopark Manasnayakorn, Suthat Chottanapund, Pattarawat Thantiworasit, Peeriya Prueksakaew, Nisakorn Ratnaratorn, Bessara Nuntapinit, Lawrence Fox, Sodsai Tovanabutra, Dominic Paquin-Proulx, Lindsay Wieczorek, Victoria R. Polonis, Frank Maldarelli, Elias K Haddad, Praphan Phanuphak, Carlo Sacdalan, Morgane Rolland, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Guido Ferrari, Lydie Trautmann |
Journal of Clinical Investigation | 2022 |
|
IFNalpha-blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health
Louise A Swainson, Ashish A Sharma, Khader Ghneim, Susan P Ribeiro, Peter Wilkinson, Richard M. Dunham, Rebecca G Albright, Samson Wong, Jacob Estes, Michael Piatak, Steven Deeks, Peter W. Hunt, Rafick-Pierre Sekaly, Joseph M. McCune |
JCI Insight | 2022 |
|
So Pathogenic or So What?—A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research
A Kleinman, I Pandrea, C Apetrei |
Viruses | 2022 |
|
Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques
A Ortiz, J Simpson, C Langner, P Baker, C Aguilar, K Brooks, J Flynn, C Vinton, A Rahmberg, H Hickman, J Brenchley |
Scientific Reports | 2022 |
|
Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice.
Yuan Z, Giron LB, Hart C, Gyampoh A, Koshy J, Hong KY, Niki T, Premeaux TA, Ndhlovu LC, Deleage C, Montaner LJ, Abdel-Mohsen M |
AIDS | 2022 |
|
Cardiovascular Disease and Thrombosis in HIV Infection.
Perkins MV, Joseph SB, Dittmer DP, Mackman N |
Arteriosclerosis, thrombosis, and vascular biology | 2022 |
|
Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy
Adrienne E Swanstrom, Taina T Immonen, Kelli Oswald, Cathi Pyle, James A. Thomas, William J Bosche, Lorna Silipino, Michael Hull, Laura Newman, Vicky Coalter, Adam Wiles, Rodney Wiles, Jacob Kiser, David R Morcock, Rebecca Shoemaker, Randy Fast, Matthew W. Breed, Joshua Kramer, Duncan Donohue, Tyler Malys, Christine Fennessey, Charles M. Trubey, Claire Deleage, Jacob D Estes, Jeffrey D Lifson, Brandon F Keele, Gregory Q Del Prete |
Journal of Clinical Investigation | 2021 |
|
The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection
QL Hingrat, I Sereti, AL Landay, I Pandrea, C Apetrei |
Frontiers in immunology | 2021 |
|
IL-17A reprograms intestinal epithelial cells to facilitate HIV-1 replication and outgrowth in CD4+ T cells
TR Salinas, A Gosselin, LR Marchand, EM Gabriel, O Tastet, JP Goulet, Y Zhang, D Vlad, H Touil, JP Routy, MG Bego, M El-Far, N Chomont, AL Landay, ÉA Cohen, C Tremblay, P Ancuta |
iScience | 2021 |
|
Gut Innate Immunity and HIV Pathogenesis
SM Dillon, CC Wilson |
Current HIV/AIDS Reports | 2021 |
|
Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease
CS Wong, CM Buckner, SL Lage, L Pei, FL Assis, EW Dahlstrom, SL Anzick, K Virtaneva, A Rupert, JL Davis, T Zhou, E Laidlaw, M Manion, F Galindo, M Anderson, CA Seamon, MC Sneller, A Lisco, C Deleage, S Pittaluga, S Moir, I Sereti |
Frontiers in immunology | 2021 |
|
Circulating β- d -Glucan as a Marker of Subclinical Coronary Plaque in Antiretroviral Therapy-Treated People With Human Immunodeficiency Virus
S Isnard, B Fombuena, M Sadouni, J Lin, C Richard, B Routy, J Ouyang, R Ramendra, X Peng, Y Zhang, M Finkelman, D Tremblay-Sher, C Tremblay, C Chartrand-Lefebvre, M Durand, JP Routy |
Open Forum Infectious Diseases | 2021 |
|
Preferential and persistent impact of acute HIV-1 infection on CD4 + iNKT cells in colonic mucosa
D Paquin-Proulx, KG Lal, Y Phuang-Ngern, M Creegan, A Tokarev, S Suhkumvittaya, A Alrubayyi, E Kroon, S Pinyakorn, BM Slike, DL Bolton, SJ Krebs, LA Eller, C Sajjaweerawan, A Pagliuzza, N Chomont, R Rerknimitr, N Chomchey, N Phanuphak, MS de Souza, NL Michael, ML Robb, J Ananworanich, JK Sandberg, MA Eller, A Schuetz |
Proceedings of the National Academy of Sciences | 2021 |
|
HIV replication and latency in monocytes and macrophages.
Veenhuis RT, Abreu CM, Shirk EN, Gama L, Clements JE |
Seminars in Immunology | 2021 |
|
HIV persistence in subsets of CD4+ T cells: 50 shades of reservoirs
R Fromentin, N Chomont |
Seminars in Immunology | 2020 |
|
African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity
KD Raehtz, F Barrenäs, C Xu, K Busman-Sahay, A Valentine, L Law, D Ma, BB Policicchio, V Wijewardana, E Brocca-Cofano, A Trichel, M Gale, BF Keele, JD Estes, C Apetrei, I Pandrea, DT Evans |
PLoS pathogens | 2020 |
|
Evolution and Diversity of Immune Responses during Acute HIV Infection
SW Kazer, BD Walker, AK Shalek |
Immunity | 2020 |
|
High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood
S Petkov, Y Bekele, T Lakshmikanth, B Hejdeman, M Zazzi, P Brodin, F Chiodi |
Scientific Reports | 2020 |
|
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection
L Leyre, E Kroon, C Vandergeeten, C Sacdalan, DJ Colby, S Buranapraditkun, A Schuetz, N Chomchey, M de Souza, W Bakeman, R Fromentin, S Pinyakorn, S Akapirat, R Trichavaroj, S Chottanapund, S Manasnayakorn, R Rerknimitr, P Wattanaboonyoungcharoen, JH Kim, S Tovanabutra, TW Schacker, R OConnell, VG Valcour, P Phanuphak, ML Robb, N Michael, L Trautmann, N Phanuphak, J Ananworanich, N Chomont |
Science Translational Medicine | 2020 |
|
SARS-CoV-2 infection protects against rechallenge in rhesus macaques
A Chandrashekar, J Liu, AJ Martinot, K McMahan, NB Mercado, L Peter, LH Tostanoski, J Yu, Z Maliga, M Nekorchuk, K Busman-Sahay, M Terry, LM Wrijil, S Ducat, DR Martinez, C Atyeo, S Fischinger, JS Burke, MD Slein, L Pessaint, AV Ry, J Greenhouse, T Taylor, K Blade, A Cook, B Finneyfrock, R Brown, E Teow, J Velasco, R Zahn, F Wegmann, P Abbink, EA Bondzie, G Dagotto, MS Gebre, X He, C Jacob-Dolan, N Kordana, Z Li, MA Lifton, SH Mahrokhian, LF Maxfield, R Nityanandam, JP Nkolola, AG Schmidt, AD Miller, RS Baric, G Alter, PK Sorger, JD Estes, H Andersen, MG Lewis, DH Barouch |
Science | 2020 |
|
Next-generation Viral RNA/DNA in situ Hybridization Applications in Human Immunodeficiency Virus/Simian Immunodeficiency Virus Research
C Brands, D Morcock, J Estes, C Deleage |
Journal of visualized experiments : JoVE | 2020 |
|
Mass Cytometry identifies distinct CD4+T cell clusters distinguishing HIV-1 infected patients according to ART initiation
yonas bekele, Tadepally Lakshmikanth, Yang Chen, Jaromir Mikes, Aikaterini Nasi, Stefan Petkov, Bo Hejdeman, Petter Brodin, Francesca Chiodi |
JCI Insight | 2019 |
|
TLR7 agonist administration to SIV-infected macaques receiving early-initiated cART does not induce plasma viremia
Gregory Del Prete, W. Gregory Alvord, Yuan Li, Claire Deleage, Mukta Nag, Kelli Oswald, James A Thomas, Cathi Pyle, William Bosche, Vicky Coalter, Adam Wiles, Rodney Wiles, Brian Berkemeier, Michael Hull, Elizabeth Chipriano, Lorna Silipino, Randy Fast, Jacob Kiser, Rebecca Kiser, Tyler Malys, Joshua Kramer, Matthew Breed, Charles M. Trubey, Jacob Estes, Tiffany L Barnes, Joseph Hesselgesser, Romas Geleziunas, Jeffery Lifson |
JCI Insight | 2019 |
|
Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond
BL Shacklett |
Current immunology reviews | 2019 |
|
Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post–Combination Antiretroviral Therapy CD4 + T Cell Counts and Body Weight
LA Swainson, H Ahn, P Pajanirassa, V Khetarpal, C Deleage, JD Estes, PW Hunt, I Munoz-Sanjuan, JM McCune |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
|
Antiretroviral Therapy Administration in Healthy Rhesus Macaques Is Associated with Transient Shifts in Intestinal Bacterial Diversity and Modest Immunological Perturbations
AM Ortiz, JK Flynn, SR DiNapoli, O Sortino, I Vujkovic-Cvijin, Y Belkaid, I Sereti, JM Brenchley, F Kirchhoff |
Journal of virology | 2019 |
|
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection
A Yero, O Farnos, H Rabezanahary, G Racine, J Estaquier, MA Jenabian, G Silvestri |
Journal of virology | 2019 |
|
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
MH Schleimann, ML Kobberø, LK Vibholm, K Kjær, LB Giron, K Busman-Sahay, CN Chan, M Nekorchuk, M Schmidt, B Wittig, TE Damsgaard, P Ahlburg, MB Hellfritzsch, K Zuwala, FH Rothemejer, R Olesen, P Schommers, F Klein, H Dweep, A Kossenkov, JR Nyengaard, JD Estes, M Abdel-Mohsen, L Østergaard, M Tolstrup, OS Søgaard, PW Denton |
EBioMedicine | 2019 |
|
Responses to Quadrivalent Influenza Vaccine Reveal Distinct Circulating CD4+CXCR5+ T Cell Subsets in Men Living with HIV
ME Cole, Z Saeed, AT Shaw, Y Guo, K Höschler, A Winston, GS Cooke, S Fidler, GP Taylor, KM Pollock |
Scientific Reports | 2019 |
|
Tissue issues: mucosal T-cell responses in HIV-1 infection
BL Shacklett, AL Ferre, BE Kiniry |
Current Opinion in HIV and AIDS | 2019 |
|
Defining early SIV replication and dissemination dynamics following vaginal transmission
C Deleage, TT Immonen, CM Fennessey, A Reynaldi, C Reid, L Newman, L Lipkey, TE Schlub, C Camus, S OBrien, J Smedley, JM Conway, GQ Prete, MP Davenport, JD Lifson, JD Estes, BF Keele |
Science Advances | 2019 |
|
HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration
I Vujkovic-Cvijin, M Somsouk |
Current HIV/AIDS Reports | 2019 |
|
Impact of Acute HIV Infection and Early Antiretroviral Therapy on the Human Gut Microbiome
O Sortino, N Phanuphak, A Schuetz, AM Ortiz, N Chomchey, Y Belkaid, J Davis, HA Mystakelis, M Quiñones, C Deleage, B Ingram, R Rerknimitr, S Pinyakorn, A Rupert, ML Robb, J Ananworanich, J Brenchley, I Sereti, N Teeratakulpisarn, S Pattanachaiwit, M de Souza, J Fletcher, E Kroon, P Tantivitayakul, D Suttichom, S Rattanamanee, K Poltavee, J Intasan, T Luekasemsuk, H Savadsuk, S Tipsuk, S Puttamsawin, K Benjapornpong, N Ratnaratorn, P Eamyoung, S Ubolyam, R OConnell, S Akapirat, B Nuntapinit, N Tantibul, N Churikanont, S Getchalarat, S Vasan, R Trichavaroj, C Sajiaweerawan, Y Phuang-Ngern, S Jongrakthaitae, S Sukhumvittaya, P Saetun, W Chuenarom, N Michael, E Turk, C McCullough, O Butterworth, M Milazzo |
Open Forum Infectious Diseases | 2019 |
|
Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC + CD4 + cell levels: a surrogate marker candidate of HIV-induced intestinal damage
MJ Ploquin, A Casrouge, Y Madec, N Noël, B Jacquelin, N Huot, D Duffy, SP Jochems, L Micci, C Lécuroux, F Boufassa, T Booiman, T Garcia-Tellez, M Ghislain, RL Grand, O Lambotte, N Kootstra, L Meyer, C Goujard, M Paiardini, ML Albert, M Müller-Trutwin |
Journal of the International AIDS Society | 2018 |
|
A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals
LR Cockerham, SA Yukl, K Harvill, M Somsouk, SK Joshi, E Sinclair, T Liegler, R Hoh, S Lyons, PW Hunt, A Rupert, I Sereti, DR Morcock, A Rhodes, C Emson, MK Hellerstein, JD Estes, S Lewin, SG Deeks, H Hatano |
Pathogens and Immunity | 2017 |
|
Primary HIV Infection: Clinical Presentation, Testing, and Treatment
A Henn, C Flateau, S Gallien |
Current Infectious Disease Reports | 2017 |
|
Long-term Use of Proton Pump Inhibitors Is Associated With Increased Microbial Product Translocation, Innate Immune Activation, and Reduced Immunologic Recovery in Patients With Chronic Human Immunodeficiency Virus-1 Infection
JA Serpa, AM Rueda, A Somasunderam, NS Utay, D Lewis, JP Couturier, KG Breaux, M Rodriguez-Barradas |
Clinical Infectious Diseases | 2017 |
|
Plasma Cytokine Predictors of Tuberculosis Recurrence in Antiretroviral-Treated Human Immunodeficiency Virus-infected Individuals from Durban, South Africa
A Sivro, LR McKinnon, N Yende-Zuma, S Gengiah, N Samsunder, SS Karim, K Naidoo |
Clinical Infectious Diseases | 2017 |
|
Gut reactions: How the blood–brain barrier connects the microbiome and the brain
AF Logsdon, MA Erickson, EM Rhea, TS Salameh, WA Banks |
Experimental biology and medicine (Maywood, N.J.) | 2017 |
|
Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication
AJ Ericsen, M Lauck, MS Mohns, SR DiNapoli, JP Mutschler, JM Greene, JT Weinfurter, G Lehrer-Brey, TM Prall, SM Gieger, CR Buechler, KA Crosno, EJ Peterson, MR Reynolds, RW Wiseman, BJ Burwitz, JD Estes, JB Sacha, TC Friedrich, JM Brenchley, DH OConnor, DC Douek |
PLoS pathogens | 2016 |
|
Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection
I Sereti, SJ Krebs, N Phanuphak, JL Fletcher, B Slike, S Pinyakorn, RJ O'Connell, A Rupert, N Chomont, V Valcour, JH Kim, ML Robb, NL Michael, DC Douek, J Ananworanich, NS Utay |
Clinical Infectious Diseases | 2016 |
