Fingolimod (FTY720, Gilenya), a sphingosine-1-phosphate receptor (S1PR) modulator, is one of the first-line immunomodulatory therapies for treatment of relapsing-remitting multiple sclerosis (MS). Human
Hsing-Chuan Tsai, Yingxiang Huang, Christopher S. Garris, Monica A. Moreno, Christina W. Griffin, May H. Han
CCR6-mediated encephalitogenic cell homing overrode FTY720-induced lymphocyte retention in S1PR1(S5A) EAE mice.