ResearchIn-Press PreviewImmunologyOncology
Open Access | 
10.1172/jci.insight.205779
CDH3-directed immunotherapy targets basal-like hormone receptor negative prostate cancer and breast cancer
Guoqiang Liu,1 Shiyu Wang,2 Ziyu Zeng,2 Loan Duong,1 Jing Yang,2 Nipuni Barupala,2 Yun Zhao,2 Sharif Rahmy,1 Shan Feng,2 Xiaotian Chi,2 Ariana Arce,2 Linchuan Jia,3 Jun Wan,4 Liang Cheng,5 Xuemin Lu,2 and Xin Lu1
1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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Wang, S.
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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Yang, J.
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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Wan, J.
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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1Integrated Biomedical Science Graduate Program, University of Notre Dame, Notre Dame, United States of America
2Department of Biological Sciences, University of Notre Dame, Notre Dame, United States of America
3iSURE Program, University of Notre Dame, Notre Dame, United States of America
4Department of Medical and Molecular Genetics, Center for Computational Biol, Indiana University School of Medicine, Indianapolis, United States of America
5Department of Pathology and Laboratory Medicine, Department of Surgery, Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, United States of America
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Published November 3, 2026 - More info
Copyright © 2026, Liu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
