ResearchIn-Press PreviewNephrology
Open Access | 
10.1172/jci.insight.205034
Lactate controls glomerular endothelial barrier integrity in lupus nephritis
Jiaxin Lei,1 Xingyu Zhai,1 Yixin Wang,1 Ying Li,1 Lei Li,2 Mengdi Liu,1 Jing Guo,1 Lingyi Li,1 Zhezhuyun Chen,3 Qinghua Cao,4 Zhichun Liu,2 Ting Liu,5 Lin Xu,6 and Zhenke Wen1
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Lei, J. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Zhai, X. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Wang, Y. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Li, Y. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Li, L. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Liu, M. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Guo, J. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Li, L. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Chen, Z. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Cao, Q. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Liu, Z. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Liu, T. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
Find articles by Xu, L. in: PubMed | Google Scholar
1Department of Pulmonary and Critical Care Medicine, Soochow University, Suzhou, China
2Department of Rheumatology, Soochow University, Suzhou, China
3School of Biomedical Sciences, The University of Leeds, Leeds, United Kingdom
4Kolling Institute of Medical Research, University of Sydney, St Leonards, Australia
5Department of Rheumatology, Nanjing Medical University, Wuxi, China
6Department of Immunology, Zunyi Medical University, Zunyi, China
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Wen, Z.
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Published August 18, 2026 - More info
Copyright © 2026, Lei et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
