Clinical MedicineIn-Press PreviewAIDS/HIVImmunology Open Access | 10.1172/jci.insight.182312
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Jimenez-Leon, M. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Gasca-Capote, C. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Roca-Oporto, C. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Espinosa, N. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Sobrino, S. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Fontillon-Alberdi, M. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Gao, C. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Roseto, I. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Gladkov, G. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Rivas-Jeremias, I. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Neukam, K. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Sanchez-Hernandez, J. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Rigo-Bonnin, R. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Cervera-Barajas, A. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Mesones, R. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by García, F. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Alvarez-Rios, A. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Bachiller, S. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Vitalle, J. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Perez-Gomez, A. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Camacho-Sojo, M. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Gallego, I. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Brander, C. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by McGowan, I. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Mothe, B. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Viciana, P. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Yu, X. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Lichterfeld, M. in: JCI | PubMed | Google Scholar
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Lopez-Cortes, L. in: JCI | PubMed | Google Scholar |
1Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
2Digestive Service, Virgen del Rocío University Hospital, Seville, Spain
3Service of Pathological Anatomy, Virgen del Rocío University Hospital, Seville, Spain
4Ragon Institute of MGH, MIT and Harvard, Cambridge, United States of America
5Pharmacy Service, University Hospital of Salamanca-IBSAL, Salamanca, Spain
6Clinical Laboratory, University Hospital Bellvitge, Barcelona, Spain
7Clinical Trials Units, Virgen del Rocío University Hospital, Seville, Spain
8Microbiology, San Cecilio University Hospital, Granada, Spain
9Biochemistry Service, Virgen del Rocío University Hospital, Seville, Spain
10Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío Unive, Seville, Spain
11AELIX Therapeutics S.L, Barcelona, Spain
12IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujo, Badalona, Spain
Find articles by Ruiz-Mateos, E. in: JCI | PubMed | Google Scholar |
Published July 9, 2024 - More info
We evaluated the safety and viral rebound, after analytical treatment interruption (ATI), of vedolizumab and ART in recent HIV-1 infection. We used this model to analyze the impact of α4β7 on the HIV-1 reservoir size. Participants started ART with monthly Vedolizumab infusions and ATI was performed at week 24. Biopsies were obtained from ileum and caecum at baseline and week 24. Vedolizumab levels, HIV-1 reservoir, flow cytometry and cell-sorting and antibody competition experiments were assayed. Vedolizumab was safe and well-tolerated. No participant achieved undetectable viremia off ART 24 weeks after ATI. Only a modest effect on the time to achieve >1000 HIV-RNA copies/mL and the proportion of participants off ART was observed, being higher compared to historical controls. Just before ATI, α4β7 expression was associated with HIV-1 DNA and RNA in peripheral blood and with PD1 and TIGIT levels. Importantly, a complete blocking of α4β7 was observed on peripheral CD4+ T-cells but not in gut (ileum and caecum), where α4β7 blockade and vedolizumab levels were inversely associated with HIV-1 DNA. Our findings support α4β7 as an important determinant in HIV-1 reservoir size, suggesting the complete α4β7 blockade in tissue as a promising tool for HIV-cure combination strategies.