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ResearchIn-Press PreviewCOVID-19Oncology Open Access | 10.1172/jci.insight.163434

Selective suppression of de novo SARS-CoV2 vaccine antibody responses in cancer patients on B cell-targeted therapy

Joseph H. Azar,1 John P. Evans,2 Madison H. Sikorski,1 Karthik B. Chakravarthy,3 Selah McKenney,1 Ian Carmody,1 Cong Zeng,2 Rachael Teodorescu,1 No-Joon Song,1 Jamie L. Hamon,4 Donna Bucci,3 Maria Velegraki,3 Chelsea Bolyard,5 Kevin P. Weller,5 Sarah A. Reisinger,1 Seema A. Bhat,1 Kami J. Maddocks,1 Nathan Denlinger,1 Narendranath Epperla,1 Richard Gumina,1 Anastasia N. Vlasova,6 Eugene Oltz,7 Linda Saif,6 Dongjun Chung,9 Jennifer A. Woyach,1 Peter G. Shields,1 Shan-Lu Liu,2 Zihai Li,4 and Mark P. Rubinstein1

1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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1Department of Internal Medicine, The Ohio State University, Columbus, United States of America

2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America

3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America

4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America

5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America

6Center for Food Animal Health, The Ohio State University, Columbus, United States of America

7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America

8Center for Food Animal Health, The Ohio State University, Wooster, United States of America

9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America

10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America

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Published February 7, 2023 - More info

JCI Insight. https://doi.org/10.1172/jci.insight.163434.
Copyright © 2023, Azar et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published February 7, 2023 - Version history
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Abstract

We assessed vaccine-induced antibody responses to the SARS-CoV2 ancestral virus and Omicron variant before and after booster immunization in 57 patients with B-cell malignancies. Over one third of vaccinated patients at the pre-booster timepoint were seronegative, and these patients were predominantly on active cancer therapies such as anti-CD20 monoclonal antibody. While booster immunization was able to induce detectable antibodies in a small fraction of seronegative patients, the overall booster benefit was disproportionately evident in patients already seropositive and not receiving active therapy. While ancestral and Omicron-reactive antibody levels among individual patients were largely concordant, neutralizing antibodies against Omicron tended to be reduced. Interestingly, in all patients, including those unable to generate detectable antibodies against SARS-CoV2 spike, we observed comparable levels of EBV and influenza reactive antibodies demonstrating that B cell-targeting therapies primarily impair de novo but not pre-existing antibody levels. These findings support rationale for vaccination prior to cancer treatment.

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  • Version 1 (February 7, 2023): In-Press Preview
  • Version 2 (March 22, 2023): Electronic publication

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