ResearchIn-Press PreviewCOVID-19Oncology
Open Access | 10.1172/jci.insight.163434
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Azar, J. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Evans, J.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Sikorski, M.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Chakravarthy, K. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by McKenney, S. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Carmody, I. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Zeng, C.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Teodorescu, R. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Song, N. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Hamon, J. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Bucci, D. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Velegraki, M.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Bolyard, C. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Weller, K. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Reisinger, S.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Bhat, S. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Maddocks, K. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Denlinger, N.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Epperla, N.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Gumina, R. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Vlasova, A. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Oltz, E. in: PubMed | Google Scholar
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Saif, L.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Chung, D.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Woyach, J.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Shields, P.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Liu, S.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by
Li, Z.
in:
PubMed
|
Google Scholar
|
1Department of Internal Medicine, The Ohio State University, Columbus, United States of America
2Department of Veterinary Biosciences, The Ohio State University, Columbus, United States of America
3Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, United States of America
4Pelotonia Institute of Immuno-Oncology, The Ohio State University, Columbus, United States of America
5Pelotonia Institute for Immuno-Oncology, The Ohio Satate University, Columbus, United States of America
6Center for Food Animal Health, The Ohio State University, Columbus, United States of America
7Department of Microbial Infection and Immunity, The Ohio State University, Columbus, United States of America
8Center for Food Animal Health, The Ohio State University, Wooster, United States of America
9Department of Biomedical Informatics, The Ohio State University, Columbus, United States of America
10Pelotonia Institute of Immuno-Oncology, The Ohio State University, Colombus, United States of America
Find articles by Rubinstein, M. in: PubMed | Google Scholar
Published February 7, 2023 - More info
We assessed vaccine-induced antibody responses to the SARS-CoV2 ancestral virus and Omicron variant before and after booster immunization in 57 patients with B-cell malignancies. Over one third of vaccinated patients at the pre-booster timepoint were seronegative, and these patients were predominantly on active cancer therapies such as anti-CD20 monoclonal antibody. While booster immunization was able to induce detectable antibodies in a small fraction of seronegative patients, the overall booster benefit was disproportionately evident in patients already seropositive and not receiving active therapy. While ancestral and Omicron-reactive antibody levels among individual patients were largely concordant, neutralizing antibodies against Omicron tended to be reduced. Interestingly, in all patients, including those unable to generate detectable antibodies against SARS-CoV2 spike, we observed comparable levels of EBV and influenza reactive antibodies demonstrating that B cell-targeting therapies primarily impair de novo but not pre-existing antibody levels. These findings support rationale for vaccination prior to cancer treatment.